scholarly journals Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia

2016 ◽  
Vol 24 (4) ◽  
pp. 377-386
Author(s):  
Mureșan Daniel ◽  
Andreea Cătană ◽  
Radu Anghel Popp ◽  
Diana Elena Dumitraș ◽  
Florin Stamatian ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Cervical Dysplasia ◽  
Intraepithelial Neoplasia ◽  
Predictive Score ◽  
Glutathione S Transferase ◽  
Chi Square ◽  
In Situ Carcinoma ◽  
Glutathione S Transferases ◽  
Level Of Significance

Abstract Aim: The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia. Materials and Methods: A prospective case-control study has been designed including 69 cases with different degrees of cervical dysplasia and 107 controls. All patients had been examined colposcopically. For every patient both cervical and blood specimen have been obtained. The peripheral blood was used for GST M/T genotyping. The statistical analysis was performed using OR and chi-square at a level of significance inferior to 0.05. Results: No statistically significant differences had been found between cases and controls for GST T-/M- geno-type (T-/M-, χ2=0.03, p= 0.8610) and T+/M+ χ2=0.65, p = 0.4197. Patients with in situ carcinoma had significant GST genotype association for T-/M+ genotype (OR=4.66, CI 95% [0.6528,24.9725], χ2=4.6, p=0.0314) and for T+/M- genotype (OR=0.12, CI 95% [0.0027,0.9465], χ2=0.05, p=0.0219). Conclusion: The combination of GST genotypes can be included in a predictive score for patients with cervical carcinoma.

scholarly journals VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Ioana Cristina Rotar ◽  
Diana Elena Dumitras ◽  
Radu Anghel Popp ◽  
Felicia Maria Petrisor ◽  
Paul Cotutiu ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Potential Role ◽  
Cervical Dysplasia ◽  
Inverse Correlation ◽  
Intraepithelial Neoplasia ◽  
Hpv Testing ◽  
Chi Square ◽  
Level Of Significance ◽  
Cervical Specimen

Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia.Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05.Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517],p=0.0866.Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.

Thermal Coagulation Device for Treating Cervical Dysplasia

2018 ◽  
Vol 26 (2) ◽  
pp. 149-152 ◽  
Author(s):  
Ashley Langell ◽  
Timothy Pickett ◽  
Catherine Mangum ◽  
Jennwood Chen ◽  
John Langell
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Resource Constraints ◽  
Low Cost ◽  
Stakeholder Analysis ◽  
Cervical Dysplasia ◽  
Intraepithelial Neoplasia ◽  
Cervical Cancer Prevention ◽  
User Centered Design ◽  
Thermal Coagulation

Background. Cervical cancer remains a leading cause of cancer-related deaths worldwide despite being a highly preventable disease. Nine out of every 10 deaths due to cervical cancer occur in developing regions with limited access to medical care and unique resource constraints. To address cervical cancer prevention within the confines of these unique limitations, our team of students and faculty advisors at the University of Utah’s Center for Medical Innovation developed a low-cost, portable technology that utilizes thermal coagulation, a form of heat ablation, to treat cervical intraepithelial neoplasia. Methods. A multidisciplinary team of students worked with clinical and industry advisors to develop a globally applicable treatment for cervical intraepithelial neoplasia through a systematic process of problem validation, stakeholder analysis, user-centered design, business plan development, and regulatory clearance. Results. Our efforts resulted in the development of a functional, self-contained, battery-operated prototype within 72 days, followed by Food and Drug Administration clearance of a finalized device within 18 months. Conclusion. Interdisciplinary university programs that leverage the capabilities of academic-industry partnerships can accelerate the development and commercialization of affordable medical technologies to solve critical global health issues.

scholarly journals Translation and cultural adaptation of the Functional Assessment of Chronic Illness Therapy – Cervical Dysplasia (FACIT-CD) to evaluate quality of life in women with cervical intraepithelial neoplasia

2017 ◽  
Vol 15 (2) ◽  
pp. 155-161
Author(s):  
Cristiane Menezes Sirna Fregnani ◽  
José Humberto Tavares Guerreiro Fregnani ◽  
Carlos Eduardo Paiva ◽  
Eliane Marçon Barroso ◽  
Mayara Goulart de Camargos ◽  
...  
Keyword(s):  
Chronic Illness ◽  
Cervical Intraepithelial Neoplasia ◽  
Functional Assessment ◽  
Cultural Adaptation ◽  
Cervical Dysplasia ◽  
Intraepithelial Neoplasia ◽  
The United States ◽  
Expert Committee ◽  
Chronic Illness Therapy ◽  
Translation And Cultural Adaptation

ABSTRACT Objective To translate and perform the cultural adaptation of the tool Functional Assessment of Chronic Illness Therapy – Cervical Dysplasia (FACIT-CD) to the Portuguese language. Methods A descriptive cross-sectional study, with translation and cultural adaptation of the assessment tool performed according to international guidelines and the Functional Assessment of Chronic Illness Therapy (FACIT) protocol group. It involved eight experts, six from Brazil, one from Portugal and one from the United States. After translation and back-translation of the tool, the semantic analysis process was carried out. We randomly included 20 women aged between 18 and 70 years with altered cervical cytology exam, seen at the Department of Prevention and Gynecologic Oncology - Hospital de Câncer de Barretos. Results The sample consisted of women with low education level. In the first pre-test, ten women participated and half of them considered the questions CD1, CD2 and CD3 as difficult, because they did not understand the meaning of the term “pelvic area”. The question CD5, “I worry about spreading the infection”, was also considered difficult to understand by five women. After the reconsideration of the expert committee and FACIT group, the second pre-test was performed. At this stage, we concluded that the previously raised understanding problems had been solved. Conclusion The translated version of FACIT-CD in universal Portuguese language is equivalent to the original version in English and was easily understood by patients with cervical intraepithelial neoplasia.

scholarly journals Loop electrosurgical excision procedure combined with cold coagulation for cervical intraepithelial neoplasia and adenocarcinoma in-situ: A feasible treatment with a low risk of residual/recurrent disease

2020 ◽  
Author(s):  
Eun Jung Yang ◽  
Nae Ry Kim ◽  
Ji Yeon Choi ◽  
Wook Youn Kim ◽  
Sun Joo Lee
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Additional Treatment ◽  
Definitive Treatment ◽  
Resection Margins ◽  
Adenocarcinoma In Situ ◽  
Loop Electrosurgical Excision ◽  
Cold Coagulation ◽  
Loop Electrosurgical Excision Procedure

Abstract Objective This study was performed to evaluate the significance of positive resection margins (RMs) with the loop electrosurgical excision procedure combined with cold coagulation (LEEP with CC) as a definitive treatment for patients with cervical intraepithelial neoplasia (CIN) and adenocarcinoma in-situ . Methods We retrospectively reviewed 467 patients who underwent LEEP with CC. A right-angled triangular loop in a single pass followed by a CC (120°C) to the cone bed for 10 to 20 seconds was used. Pathology reports and clinical data were obtained and evaluated. Results Histopathology evaluation of LEEP tissue samples revealed the presence of CIN 1 in 69, CIN 2/3 in 366, AIS in 5 and invasive carcinoma in 16 (microinvasive squamous cell carcinoma (SCC) and invasive SCC, 13 and 3) patients. Margins were positive in 66 (14.5%) cases: 0 in CIN 1, 54 in CIN 2/3 (12.4%), 1 in AIS (20.0%) and 11 in microinvasive/invasive SCC (68.8%). Although 54 CIN2/3 patients with positive RMs did not undergo additional treatment, 1 of these (1.9%) was confirmed to have residual CIN3 at the first follow-up. Two of 8 (25.0%) microinvasive SCC patients with positive RMs were confirmed to have residual diseases (1 microinvasive SCC and 1 invasive SCC) after hysterectomy. Four out of 360 (1 positive RM, 3 negative RM) CIN cases recurred during the study period. Conclusions These results suggest that CIN patients with positive RMs after LEEP with CC may be followed up without additional treatment.

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