scholarly journals Treatment of acute cerebral ischemia using animal models: a meta-analysis

2015 ◽  
Vol 6 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Peng-Fei Wang ◽  
Yu Zhou ◽  
Huang Fang ◽  
Sen Lin ◽  
Yan-Chun Wang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Animal Models ◽  
Infarct Size ◽  
Receptor Antagonist ◽  
Meta Analysis ◽  
Extensive Literature ◽  
Calmodulin Antagonist ◽  
Occlusion Time ◽  
Acute Cerebral Ischemia ◽  
Sphingosine 1 Phosphate

AbstractBackground: There are numerous potential treatments assessed for acute cerebral ischemia using animal models. This study aimed to assess the effect of these treatments in terms of infarct size and neurobehavioral change. This meta-analysis was conducted to determine if any of these treatments provide a superior benefit so that they might be used on humans. Methods: A systematic search was conducted using several electronic databases for controlled animal studies using only nonsurgical interventions for acute cerebral ischemia. A random-effects model was used. Results: After an extensive literature search, 145 studies were included in the analysis. These studies included 1408 treated animals and 1362 control animals. Treatments that had the most significant effect on neurobehavioral scales included insulin, various antagonists, including N-methyl-Daspartate (NMDA) receptor antagonist ACEA1021, calmodulin antagonist DY-9760e, and α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist YM872, and antiviral agents. Treatments providing the greatest effect on infarct size included statins, sphingosine-1-phosphate agonist (fingolimod), alcohol, angiotensin, and leukotrienes. Treatments offering the greatest reduction in brain water content included various agonists, including sphingosine-1-phosphate agonist fingolimod, statins, and peroxisome proliferator-activated receptor gamma (PPAR-γ). Treatment groups with more than one study all had high heterogeneity (I2 > 80%), however, using meta-regression we determined several sources of heterogeneity including sample size of the treatment and control groups, the occlusion time, but not the year when the study was conducted. Conclusions: Some treatments stand out when compared to others for acute cerebral ischemia in animals. Greater replication of treatment studies is required before any treatments are selected for future human trials.

Abstract W P26: Meta-analysis Of Studies Using Solitaire And Trevo Pro Stent Retriever Devices For Mechanical Thromboembolectomy In Acute Cerebral Ischemia

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Vikram Jadhav ◽  
Mushtaq H Qureshi ◽  
Malik M Adil ◽  
Amna Zarar ◽  
Nidaullah Mian ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Publication Bias ◽  
Mechanical Thrombectomy ◽  
Meta Analysis ◽  
Analysis Software ◽  
Symptomatic Intracerebral Hemorrhage ◽  
Acute Cerebral Ischemia ◽  
Random Models ◽  
Log Odds ◽  
Event Rates

Objective: To report rates of recanalization and symptomatic intracerebral hemorrhage (SICH) after mechanical thromboembolectomy using Solitaire and Trevo Pro devices in acute cerebral ischemia using meta-analysis of published studies. Methods: We identified all studies that used Solitaire or Trevo devices for mechanical thromboembolectomy in treatment of acute cerebral ischemia using a search on PubMed and Cochrane libraries, stroke trials database, proceedings of neurology and neurosurgery related conferences, and supplemented by a review of bibliographies of selected publications. Recanalization was assessed using TICI >2a and rates of SICH were recorded. For the meta-analysis, forest plots and statistical analysis including event rates [ER] with 95% confidence intervals [CI] based on both fixed and random models were performed using Comprehensive Meta-Analysis Software. The presence of publication bias was interrogated by funnel plot of Standard Error by log odds ratio. Results: Eighteen studies with Solitaire device and five with Trevo device were identified and included in the meta-analysis. There were a total of 433/505 (85%, ER 0.85 [CI] 0.80-0.88, P<0.001) successful recanalizations with Solitaire device whereas 196/243 (80%, ER 0.80 [CI] 0.74-0.85, P<0.001) successful recanalizations were noted with Trevo device. The incidence of SICH was 45/505 (9%, ER 0.09 [CI] 0.06-0.14, P<0.001) with Solitaire device and 17/243 (6%, ER 0.06 [CI] 0.049-0129, P<0.001) with Trevo device after mechanical thrombectomy. There was no publication bias. Conclusions: Meta-analysis of studies reveals similar rates for recanalization and SICH after mechanical thromboembolectomy using Solitaire or Trevo Pro devices.

scholarly journals Effect of uric acid in animal models of ischaemic stroke: A systematic review and meta-analysis

2020 ◽  
pp. 0271678X2096745
Author(s):  
Alicia Aliena-Valero ◽  
Júlia Baixauli-Martín ◽  
María Castelló-Ruiz ◽  
Germán Torregrosa ◽  
David Hervás ◽  
...  
Keyword(s):  
Systematic Review ◽  
Uric Acid ◽  
Animal Models ◽  
Infarct Size ◽  
Ischaemic Stroke ◽  
Meta Analysis ◽  
Preclinical Research ◽  
Neuroprotective Effects ◽  
Item Checklist ◽  
Study Heterogeneity

Addition of uric acid (UA) to thrombolytic therapy, although safe, showed limited efficacy in improving patients’ stroke outcome, despite alleged neuroprotective effects of UA in preclinical research. This systematic review assessed the effects of UA on brain structural and functional outcomes in animal models of ischaemic stroke. We searched Medline, Embase and Web of Science to identify 16 and 14 eligible rodent studies for qualitative and quantitative synthesis, respectively. Range of evidence met 10 of a possible 13 STAIR criteria. Median (Q1, Q3) quality score was 7.5 (6, 10) on the CAMARADES 15-item checklist. For each outcome, we used standardised mean difference (SMD) as effect size and random-effects modelling. Meta-analysis showed that UA significantly reduced infarct size (SMD: −1.18; 95% CI [−1.47, −0.88]; p < 0.001), blood-brain barrier (BBB) impairment/oedema (SMD: −0.72; 95% CI [−0.97, −0.48]; p < 0.001) and neurofunctional deficit (SMD: −0.98; 95% CI [−1.32, −0.63]; p < 0.001). Overall, there was low to moderate between-study heterogeneity and sizeable publication bias. In conclusion, published rodent data suggest that UA improves outcome following ischaemic stroke by reducing infarct size, improving BBB integrity and ameliorating neurofunctional condition. Specific recommendations are given for further high-quality preclinical research required to better inform clinical research.

scholarly journals Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia

Stroke ◽  
2008 ◽  
Vol 39 (6) ◽  
pp. 1855-1861 ◽  
Author(s):  
Jens Minnerup ◽  
Jan Heidrich ◽  
Jürgen Wellmann ◽  
Andreas Rogalewski ◽  
Armin Schneider ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Animal Models ◽  
Focal Cerebral Ischemia ◽  
Meta Analysis ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Fever worsens outcomes in animal models of ischaemic stroke: A systematic review and meta-analysis

2018 ◽  
Vol 4 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Jeroen C de Jonge ◽  
Justin Wallet ◽  
H. Bart van der Worp
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Infarct Size ◽  
Ischaemic Stroke ◽  
Meta Analysis ◽  
Animal Experiments ◽  
Primary Outcome Measure ◽  
Artery Occlusion ◽  
Poor Outcome ◽  
The Impact

Background Subfebrile temperatures and fever in the first days after stroke are associated with a greater risk of a poor outcome. If this relation is causal, prevention of hyperthermia may improve outcome. Causality can be tested in animal models. We therefore assessed the effects of hyperthermia on outcomes in animal models of ischaemic stroke and explored under which conditions prevention of hyperthermia could be most effective. Methods We performed a systematic review and meta-analysis of data from animal experiments testing the effect of spontaneous or induced hyperthermia on outcome after focal cerebral ischaemia. Our primary outcome measure was infarct size. Normalised mean differences were combined using the random effects model and stratified meta-analysis was used to explore the impact of study characteristics. Results We included 19 publications, reporting on 49 comparisons involving 603 animals. Overall, hyperthermia increased infarct size by 43.4% (95% confidence interval, 29.8–56.9%) and worsened neurobehavioral outcomes by 48.5% (17.2–79.8%). The increase in infarct size was larger with higher temperatures. Hyperthermia was most harmful if present for more than 2 h and when started at the time of artery occlusion rather than later. Conclusion Hyperthermia substantially increased infarct size in animal models of ischaemic stroke, suggesting that the relation between fever and poor outcome observed in patients is at least in part causal. These data provide support to trials testing the effect of the prevention of fever with antipyretic drugs in patients with acute stroke.

scholarly journals Anti-inflammatory compounds to reduce infarct size in large-animal models of myocardial infarction: A meta-analysis

2014 ◽  
Vol 1 (1) ◽  
pp. e00004 ◽  
Author(s):  
G.P.J. van Hout ◽  
S.J. Jansen of Lorkeers ◽  
K.E. Wever ◽  
E.S. Sena ◽  
W.W. van Solinge ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Models ◽  
Infarct Size ◽  
Meta Analysis ◽  
Large Animal ◽  
Reduce Infarct Size ◽  
Large Animal Models ◽  
Anti Inflammatory

scholarly journals Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Haider Al-Waeli ◽  
Ana Paula Reboucas ◽  
Alaa Mansour ◽  
Martin Morris ◽  
Faleh Tamimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Healing ◽  
Bone Fracture ◽  
Bone Fractures ◽  
Meta Analysis ◽  
Biomechanical Properties ◽  
Extensive Literature ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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