Synthesis of madecassic acid derivatives and their cytotoxic activity

2018 ◽  
Vol 73 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Tran Van Loc ◽  
Vo Thi Quynh Nhu ◽  
Tran Van Chien ◽  
Le Thi Thu Ha ◽  
Tran Thi Phuong Thao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Liver Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Centella Asiatica ◽  
Hydroxyl Group ◽  
Cooh Group ◽  
Amide Derivatives ◽  
Derivatives Of

AbstractFifteen new 28-amide derivatives of madecassic acid, isolated from the tropical medicinal herb Centella asiatica (Apiaceae), have been synthesised, and their cytotoxicity on three cancer cell lines, KB (carcinoma cancer), HepG2 (liver cancer) and Lu-1 (lung cancer), was evaluated. The results showed that acetylation of the 2,3,23-hydroxyl group and/or amidation of the 28-COOH group strongly increased the cytotoxicity of the synthesised compounds.

N-Methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines

1992 ◽  
Vol 35 (26) ◽  
pp. 4854-4857 ◽  
Author(s):  
John C. Ruckdeschel ◽  
Sandeep P. Modi ◽  
Wageeh El-Hamouly ◽  
Enrico Portuese ◽  
Sydney Archer
Keyword(s):  
Lung Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Derivatives Of

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

2012 ◽  
Vol 227 (10) ◽  
pp. 3389-3396 ◽  
Author(s):  
Anna Tesei ◽  
Giovanni Brigliadori ◽  
Silvia Carloni ◽  
Francesco Fabbri ◽  
Paola Ulivi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Valproic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Hdac Inhibitor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Derivatives Of

scholarly journals SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A

2018 ◽  
Vol 54 (2C) ◽  
pp. 502
Author(s):  
Le Duc Anh
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Hep G2 ◽  
Human Cancer Cell Lines ◽  
Activity Evaluation ◽  
Derivatives Of

Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 wereprepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylationreactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,LU, RD and Fl. The result showed that both compounds exhibited no activity against the testedcell lines.

scholarly journals IN-VITRO CYTOTOXIC AND APOPTOSIS STUDY OF CHEMICAL CONSTITUENTS OF CLERODENDRUM PHLOMIDIS LEAF ON MCF-7 BREAST AND A-549 LUNG CANCER CELL LINES.

2018 ◽  
Vol 11 (5) ◽  
pp. 299
Author(s):  
Habeela Jainab N ◽  
Mohan Maruga Raja Mk
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Lung Cancer Cell ◽  
Clerodendrum Phlomidis ◽  
Mcf 7

 Objective: Cancer is a molecularly heterogeneous diseaseand the leading cause of death worldwide. The methanol extract of Clerodendrum phlomidis leaf has been reported for cytotoxicity. Hence, the current investigation was planned to evaluate the cytotoxic activity of the chemical constituents isolated from the methanol extract of the C. phlomidis leaf against the Michigan cancer foundation-7 (MCF-7) breast cancer and adenocarcinomic human alveolar basal epithelial cells (A549) lung cancer cell lines by the apoptotic study.Methods: Cytotoxic activity of the chemical constituents of the methanol extract of the C. phlomidis leaf was evaluated by the 3-(4,5-dimethylthiazol- 2-yl)-5-diphenyltetrazolium bromide (MTT) assay against breast cancer (MCF-7) and lung cancer (A549) cell lines. The MCF-7 and A549 cell lines were tested at different concentrations to determine 50% of growth inhibition (inhibitory concentration [IC50]) by MTT assay. Apoptosis of nuclei was detected by 4’,6-diamidino-2-phenylindole staining assay.Results: In MCF-7 breast cancer cell line study, Compounds 6 and 9 exhibited good cytotoxic activity with an IC50 value of 83.80 and 75.16 μg/ml, respectively. In A549 lung cancer cell line, again Compounds 6 and 9 exhibited good cytotoxic activity with an IC50 value of 84.46 and 78.60 μg/ml, respectively. Percentage of apoptosis induced by the Compounds 6 and 9 in the MCF-7 cancer cells was found to be 74.50 and 85.48, respectively.Conclusion: The results of the current study prove that the Compounds 6 and 9 are potential agents for breast and lung cancer. In future research, these potential agents can further be evaluated by animal studies and their mechanism of action apart from the induction of apoptosis of the cancer cells can be determined.

scholarly journals Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-O-Amino Ester and Hydroquinone 5-O-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 418 ◽  
Author(s):  
Supakarn Chamni ◽  
Natchanun Sirimangkalakitti ◽  
Pithi Chanvorachote ◽  
Khanit Suwanborirux ◽  
Naoki Saito
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Cytotoxic Agents ◽  
Amino Ester ◽  
Small Cell Lung ◽  
Derivatives Of

Two new series of synthetic renieramycins including 22-O-amino ester and hydroquinone 5-O-amino ester derivatives of renieramycin M were semi-synthesized and evaluated for their cytotoxicity against the metastatic non-small-cell lung cancer H292 and H460 cell lines. Interestingly, the series of 22-O-amino ester derivatives displayed a potent cytotoxic activity greater than the hydroquinone derivatives. The most cytotoxic derivative of the series was the 22-O-(N-Boc-l-glycine) ester of renieramycin M (5a: IC50 3.56 nM), which showed 7-fold higher potency than renieramycin M (IC50 24.56 nM) and 61-fold more than jorunnamycin A (IC50 217.43 nM) against H292 cells. In addition, 5a exhibited a significantly higher cytotoxic activity than doxorubicin (ca. 100 times). The new semi-synthetic renieramycin derivatives will be further studied and developed as potential cytotoxic agents for non-small-cell lung cancer treatment.

Cytotoxic activity of doxorubicin and ETA 42 immunoconjugates against drug resistant small cell lung cancer cell lines in vitro

1994 ◽  
Vol 5 ◽  
pp. 8
Author(s):  
B Froesch ◽  
U Zangemeister-Wittke ◽  
K Rose ◽  
R A Stahel
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Small Cell ◽  
Drug Resistant ◽  
Lung Cancer Cell ◽  
Small Cell Lung

In vitro cytotoxic activity of extracts from Hibiscus sabdariffa leaves against human lung cancer cell lines

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
P Worawattananutai ◽  
S Ruangnoo ◽  
A Itharat
Keyword(s):  
Lung Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Hibiscus Sabdariffa ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell
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