Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs

2005 ◽  
Vol 3 (1) ◽  
pp. 97-110 ◽  
Author(s):  
Ping Gao ◽  
Walter Morozowich
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Georgios K. Eleftheriadis ◽  
Panagiota Mantelou ◽  
Christina Karavasili ◽  
Paschalina Chatzopoulou ◽  
Dimitrios Katsantonis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals Self Emulsifying Drug Delivery System: A Recent Approach

2019 ◽  
Vol 31 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Sabitri Bindhani ◽  
S. Mohapatra ◽  
R.K. Kar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Oral Absorption ◽  
Scale Up ◽  
Aqueous Solubility ◽  
Oral Drug ◽  
Recent Approach ◽  
Poorly Soluble

In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

scholarly journals Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs

2020 ◽  
Vol 191 ◽  
pp. 111010
Author(s):  
Sidy Mouhamed Dieng ◽  
Ziad Omran ◽  
Nicolas Anton ◽  
Oumar Thioune ◽  
Alphonse Rodrigue Djiboune ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Poorly Soluble Drugs ◽  
Oral Drug Delivery System ◽  
Poorly Soluble

scholarly journals An overview of characterizations and applications of proniosomal drug delivery system

2021 ◽  
Vol 7 (2) ◽  
pp. 025-034
Author(s):  
Minakshee G. Nimbalwar ◽  
Bhushan R. Gudalwar ◽  
Wrushali A. Panchale ◽  
Ashish B. Wadekar ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Carriers ◽  
Water Soluble ◽  
Ionic Surfactant ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Proniosomal drug delivery system is a stable provesicular system in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular drug carriers coated with a non-ionic surfactant which on hydration give niosomes. The system is encapsulated and shows a systemic and targeted delivery of poorly soluble drugs with increased bioavailability and decreased side effects. Here we have covered characterizations and applications of the proniosomal drug delivery system.

Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function

2018 ◽  
Vol 66 (21) ◽  
pp. 5352-5358 ◽  
Author(s):  
Yoshiki Seto ◽  
Chikara Morizane ◽  
Kodai Ueno ◽  
Hideyuki Sato ◽  
Satomi Onoue
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Krill Oil

scholarly journals Enhanced Bioavailability of AC1497, a Novel Anticancer Drug Candidate, via a Self-Nanoemulsifying Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1142
Author(s):  
Kshitis Chandra Baral ◽  
Jae-Geun Song ◽  
Sang Hoon Lee ◽  
Rajiv Bajracharya ◽  
Godesi Sreenivasulu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plasma Concentration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Metabolism ◽  
Oral Absorption ◽  
Drug Candidate ◽  
Maximum Plasma ◽  
Time Curve ◽  
Dual Inhibitor

AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its clinical development. This study was conducted to develop an effective self-nanoemulsifying drug delivery system (SNEDDS) of AC1497 to improve its oral absorption. Based on the solubility of AC1497 in various oils, surfactants, and cosurfactants, Capryol 90, Kolliphor RH40, and Transcutol HP were selected as the components of SNEDDS. After testing various weight ratios of Capryol 90 (20–30%), Kolliphor RH40 (35–70%), and Transcutol HP (10–35%), SNEDDS-F4 containing 20% Capryol 90, 45% Kolliphor RH40, and 35% Transcutol HP was identified as an optimal SNEDDS with a narrow size distribution (17.8 ± 0.36 nm) and high encapsulation efficiency (93.6 ± 2.28%). Drug release from SNEDDS-F4 was rapid, with approximately 80% of AC1497 release in 10 min while the dissolution of the drug powder was minimal (<2%). Furthermore, SNEDDS-F4 significantly improved the oral absorption of AC1497 in rats. The maximum plasma concentration and area under the plasma concentration–time curve of AC1497 were, respectively 6.82- and 3.14-fold higher for SNEDDS-F4 than for the drug powder. In conclusion, SNEDDS-F4 with Capryol 90, Kolliphor RH40, and Transcutol HP (20:45:35, w/w) effectively improves the solubility and oral absorption of AC1497.

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