scholarly journals An overview of characterizations and applications of proniosomal drug delivery system

2021 ◽  
Vol 7 (2) ◽  
pp. 025-034
Author(s):  
Minakshee G. Nimbalwar ◽  
Bhushan R. Gudalwar ◽  
Wrushali A. Panchale ◽  
Ashish B. Wadekar ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Carriers ◽  
Water Soluble ◽  
Ionic Surfactant ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Proniosomal drug delivery system is a stable provesicular system in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular drug carriers coated with a non-ionic surfactant which on hydration give niosomes. The system is encapsulated and shows a systemic and targeted delivery of poorly soluble drugs with increased bioavailability and decreased side effects. Here we have covered characterizations and applications of the proniosomal drug delivery system.

Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Georgios K. Eleftheriadis ◽  
Panagiota Mantelou ◽  
Christina Karavasili ◽  
Paschalina Chatzopoulou ◽  
Dimitrios Katsantonis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1412
Author(s):  
Murtada A. Oshi ◽  
Juho Lee ◽  
Jihyun Kim ◽  
Nurhasni Hasan ◽  
Eunok Im ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cyclosporine A ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Systemic Absorption ◽  
Systemic Side Effects

Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated alginate microparticles (CsAc-EAMPs) was established to minimize systemic side effects and enhance the therapeutic efficacy of CsA. Homogeneously-sized CsAs (3.1 ± 0.9 μm) were prepared by anti-solvent precipitation, followed by the fabrication of 47.1 ± 6.5 μm-sized CsAc-EAMPs via ionic gelation and ES coating. CsAc-EAMPs exhibited a high drug loading capacity (48 ± 5%) and a CsA encapsulation efficacy of 77 ± 9%. The in vitro drug release study revealed that CsA release from CsAc-EAMPs was suppressed under conditions simulating the stomach and small intestine, resulting in minimized systemic absorption and side effects. Following exposure to the simulated colon conditions, along with ES dissolution and disintegration of alginate microparticles, CsA was released from CsAc-EAMPs, exhibiting a sustained-release profile for up to 24 h after administration. Given the effective colonic delivery of CsA molecules, CsAc-EAMPs conferred enhanced anti-inflammatory activity in mouse model of dextran sulfate sodium (DSS)-induced colitis. These findings suggest that CsAc-EAMPs is a promising drug delivery system for treating UC.

scholarly journals Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs

2020 ◽  
Vol 191 ◽  
pp. 111010
Author(s):  
Sidy Mouhamed Dieng ◽  
Ziad Omran ◽  
Nicolas Anton ◽  
Oumar Thioune ◽  
Alphonse Rodrigue Djiboune ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Poorly Soluble Drugs ◽  
Oral Drug Delivery System ◽  
Poorly Soluble

scholarly journals Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 480 ◽  
Author(s):  
Joachim Delasoie ◽  
Philippe Schiel ◽  
Sandra Vojnovic ◽  
Jasmina Nikodinovic-Runic ◽  
Fabio Zobi
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Fold Increase ◽  
Design Synthesis ◽  
Highly Active ◽  
Anticancer Complexes

Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B12-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial–temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient.

Self Microemulsifying Nutraceutical and Drug Delivery Systems

2014 ◽  
Vol 7 (3) ◽  
pp. 2520-2528 ◽  
Author(s):  
Vikrant P Wankhade ◽  
Nivedita S Kale ◽  
K.K Tapar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ternary Phase Diagram ◽  
Aqueous Solubility ◽  
Oral Formulation ◽  
Water Soluble ◽  
Drug Dissolution ◽  
The Novel ◽  
Peristaltic Movement

Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant, and co solvent and sometimes co surfactant. Drug is directly dispersed into the entire gastro intestinal tract with continuous peristaltic movement and drug is available in the solution form of microemulsion, absorbed through lymphatic system and bypasses the dissolution step. Hence they increase the patient compliance. The excipients are selected on basis of construction of ternary phase diagram. Self micro-emulsifying drug delivery system is very useful for drug in which drug dissolution is rate limiting step. This review describes the novel approaches and evaluation parameters of the self microemulsifying drug delivery system towards different classic drugs, proteins-peptides, and nutraceuticals in various oral microemulsion compositions and microstructures.

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