scholarly journals Celiac Crisis in a Young Woman: Raising Awareness of a Life-Threatening Condition

2019 ◽  
Vol 11 (4) ◽  
pp. 230-233
Author(s):  
Maryam Jameshorani ◽  
Akram Pourshams ◽  
Anahita Sadeghi ◽  
Hiva Saffar ◽  
Reza Malekzadeh
Keyword(s):  
Celiac Disease ◽  
Herbal Medicines ◽  
Hemodynamic Instability ◽  
Deficiency Anemia ◽  
Electrolyte Disturbances ◽  
Celiac Crisis ◽  
Raising Awareness ◽  
Clinical Presentations ◽  
Threatening Condition ◽  
Life Threatening

Celiac crisis is a rare, acute, and life-threatening presentation of celiac disease. Its clinical presentations consist of severe watery non-bloody diarrhea, electrolyte disturbances (i.e. hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and metabolic acidosis), hypoproteinemia, and dehydration. Here we present a 33-year-old woman who referred with profuse diarrhea, weight loss, hemodynamic instability, hypokalemia, hypoproteinemia, ascites, pancytopenia, and iron deficiency anemia. She used herbal medicines for constipation and had severe weakness after her childbirth. The patient was diagnosed as having celiac disease through pathological and serological evaluations 10 months earlier. Diagnosis of celiac crisis after ruling out the other causes of resistant celiac was made and she was treated with steroids.

Severe Alveolar Hemorrhage – What’s in it for the Gastroenterologist?

2016 ◽  
Vol 25 (4) ◽  
pp. 555-558
Author(s):  
Alina Popp
Keyword(s):  
Celiac Disease ◽  
International Normalized Ratio ◽  
Gluten Free Diet ◽  
Alveolar Hemorrhage ◽  
Severe Anemia ◽  
Gluten Free ◽  
Pulmonary Infiltrates ◽  
Pulmonary Hemosiderosis ◽  
Threatening Condition ◽  
Life Threatening

Background: Alveolar hemorrhage is a potentially life-threatening condition which is usually managed by the pulmonologist. When considering its etiology, there is a rare association that sets the disease into the hands of the gastroenterologist. Case presentation: We report the case of a 48 year-old female who was admitted to the intensive care unit for severe anemia and hemoptysis. On imaging, diffuse pulmonary infiltrates suggestive of alveolar hemorrhage were detected and a diagnosis of pulmonary hemosiderosis was made. She received cortisone therapy and hematologic correction of anemia, with slow recovery. In search of an etiology for the pulmonary hemosiderosis, an extensive workup was done, and celiac disease specific serology was found positive. After confirmation of celiac disease by biopsy, a diagnosis of Lane-Hamilton syndrome was established. The patient was recommended a gluten-free diet and at 6 months follow-up, resolution of anemia and pulmonary infiltrates were observed. Conclusion: Although the association is rare, celiac disease should be considered in a patient with idiopathic pulmonary hemosiderosis. In our case, severe anemia and alveolar infiltrates markedly improved with glucocorticoids and gluten-free diet. Abbreviations: APTT: activated partial thromboplastin time; BAL: bronchoalveolar lavage; CD: celiac disease; Cd: crypt depth; GFD: gluten-free diet; GI: gastrointestinal; IEL: intraepithelial lymphocyte; INR: international normalized ratio; IPH: idiopathic pu

Celiac crisis: a rare and life-threatening condition

2021 ◽  
Vol 33 (12) ◽  
pp. 1612-1613
Author(s):  
Isabel Garrido ◽  
Ana Luísa Santos ◽  
João Pacheco ◽  
Armando Peixoto ◽  
Guilherme Macedo
Keyword(s):  
Celiac Crisis ◽  
Threatening Condition ◽  
Life Threatening

scholarly journals Brain Catastrophe presented with endocrine disruption

2020 ◽  
Vol 8 (5) ◽  
pp. 104-110
Author(s):  
Saadi JS AlJadir
Keyword(s):  
Dynamic Testing ◽  
Hemodynamic Instability ◽  
Major Surgery ◽  
Initial Manifestation ◽  
Altered Level ◽  
Identifiable Risk Factor ◽  
Conflicting Evidence ◽  
Level Of Consciousness ◽  
Threatening Condition ◽  
Life Threatening

Pituitary Apoplexy (PA) is an acute critical endocrine condition that is infrequently encountered in daily medical practice. Its life-threatening condition that mandates prompt diagnosis and urgent treatment and may be neurosurgical intervention. Majority of cases are attributed to ischemic infarction or hemorrhage of the pituitary gland usually in the vicinity of pituitary adenoma, and in most cases could be the initial manifestation of these tumors! In reviewing the literatures there is conflicting evidence of which are the predominant, non-functional, or functional adenomas, some reports were showed that prolactin-secreting are at highest risk. There are recognizable risk factors that might precipitate this endocrine emergency like hypertension, medications, major surgery, head injury, radiation, or dynamic testing, but in majority of cases at presentation no identifiable risk factor could be detected. The typical clinical scenario includes persistent worsening headache, vomiting, and altered level of consciousness, visual defect or loss with extreme hormonal derangements which are shown by hemodynamic instability, adrenal crises with variable hormonal deficiencies.

An approach to neuroleptic malignant syndrome from a clinical case

2016 ◽  
Vol 33 (S1) ◽  
pp. S631-S632 ◽  
Author(s):  
A. Gomez Peinado ◽  
P. Cano Ruiz ◽  
M.D. Sanchez Garcia ◽  
S. Cañas Fraile ◽  
M. Gonzalez Cano ◽  
...  
Keyword(s):  
Neuroleptic Malignant Syndrome ◽  
Clinical Case ◽  
Medical Complication ◽  
Neuroleptic Treatment ◽  
Autonomic Nervous System Dysfunction ◽  
Electrolyte Disturbances ◽  
Starting Point ◽  
Threatening Condition ◽  
Life Threatening ◽  
Competing Interest

IntroductionNeuroleptic malignant syndrome (NMS) takes place in patients in treatment with neuroleptics and it is potentially lethal, being important an early diagnostic and therapeutic approach.ObjectivesTo analyze from a clinical case the clinical and epidemiological features, and therapeutical approach to NMS.MethodReview of some articles in Mental Health journals and analysis of the following clinical case: 68-year-old woman with bipolar disorder, hospitalized in manic phase. Usual treatment: lithium, trazodone, quetiapine and asenapine. During the admission to hospital, the patient started presenting hyperthermia, sweating, electrolyte disturbances, limb rigidity, and elevation of CPK levels. The suspicion was NMS, so neuroleptics were stopped and fluids and dantrolene were initiated, with favorable evolution.ResultsThe discharge diagnosis was NMS. Neuroleptics were gradually reintroduced under vigilance. The patient is stable and has not had new complications. NMS is an uncommon (0.02% to 3% among patients taking neuroleptic agents), but life-threatening condition. Its symptoms are hyperthermia, autonomic nervous system dysfunction, limb rigidity, altered consciousness… The attendant infections, consume of lithium, dehydration, iron deficiency and sharp changes in neuroleptic treatment are predisposing factors. The withdrawal of neuroleptics is the key of the treatment. Benzodiazepines can improve the prognosis, and electroconvulsive therapy can be necessary if there is no response to previous measures.ConclusionsNeuroleptic malignant syndrome is a life-threatening medical complication we should try to avoid by a correct and careful use of neuroleptics. Additionally, it is important the early treatment, taking withdrawal of neuroleptics as the key starting point.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Celiac Crisis as a First Presentation of Celiac Disease: A Life-Threatening Syndrome

2014 ◽  
Vol 109 ◽  
pp. S319
Author(s):  
Marvin Lopez ◽  
Eduardo Rodriguez ◽  
Maria Perez ◽  
Daniel Sussman
Keyword(s):  
Celiac Disease ◽  
Celiac Crisis ◽  
Life Threatening

scholarly journals Place of bronchoscopy in the diagnostics and follow-up of patients with idiopathic pulmonary hemosiderosis

Folia Medica ◽  
2021 ◽  
Vol 63 (4) ◽  
pp. 582-585
Author(s):  
Ivanka P. Karavelikova
Keyword(s):  
Iron Deficiency ◽  
Pulmonary Fibrosis ◽  
Early Diagnosis ◽  
Iron Deficiency Anemia ◽  
Chest Radiography ◽  
Deficiency Anemia ◽  
Pulmonary Hemosiderosis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Idiopathic Pulmonary Hemosiderosis

The idiopathic pulmonary hemosiderosis is a rare, life-threatening condition observed mainly in children and characterized by recurrent episodes of diffuse alveolar hemorrhages. The disease is characterized by the triad of hemoptysis, alveolar infiltrates in chest radiography, and iron-deficiency anemia. The recurrent episodes of alveolar hemorrhage can lead to chronic iron-deficiency anemia and irreversible pulmonary fibrosis; therefore, early diagnosis and treatment are crucial to the outcome of the disease.The idiopathic pulmonary hemosiderosis is a rare, life-threatening condition observed mainly in children and characterized by recurrent episodes of diffuse alveolar hemorrhages. The disease is characterized by the triad of hemoptysis, alveolar infiltrates in chest radiography, and iron-deficiency anemia. The recurrent episodes of alveolar hemorrhage can lead to chronic iron-deficiency anemia and irreversible pulmonary fibrosis; therefore, early diagnosis and treatment are crucial to the outcome of the disease.

scholarly journals Cardiotoxic Effects of Yew Tree and Pink Periwinkle Alkaloids

2021 ◽  
Vol 9 (4) ◽  
pp. 165-172
Author(s):  
G. S. Mal ◽  
E. B. Artyushkova ◽  
M. P. Gladchenko ◽  
A. A. Ivanova
Keyword(s):  
Haematological Toxicity ◽  
Herbal Medicines ◽  
Cardiac Complications ◽  
Vinca Alkaloids ◽  
Anthracycline Antibiotics ◽  
Treatment Regimens ◽  
Drug Classes ◽  
Raising Awareness ◽  
Life Threatening ◽  
Yew Tree

Antitumour herbal medicines based on pink periwinkle and yew tree alkaloids are included in combination therapies for many types of cancer. The use of these classes of products may entail cardiotoxic effects leading to life-threatening conditions. The aim of the study was to analyse scientific literature on cardiotoxic effects of anticancer drugs based on yew tree alkaloids (taxanes) and pink periwinkle alkaloids (vinca alkaloids). The results of the analysis demonstrated that the main manifestations of taxane-induced cardiotoxicity were bradycardia, atrioventricular block, atrial and ventricular arrhythmias. Concomitant use of taxanes and anthracycline antibiotics exacerbated cardiotoxic effects of both drug classes. The use of vinca alkaloids was associated with haematological toxicity in the form of neutropenia, while cardiotoxic effect was rarely observed during monotherapy. Raising awareness among oncologists, cardiologists, and other specialists involved in the management of cancer patients about potential cardiac complications of antitumour therapy contributes to early detection of adverse reactions and allows for individual correction of treatment regimens, especially in patients with predisposition to cardiovascular disease.

scholarly journals Deep Venous Thrombosis and Bilateral Pulmonary Embolism Revealing Silent Celiac Disease: Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Igor Dumic ◽  
Scott Martin ◽  
Nadim Salfiti ◽  
Robert Watson ◽  
Tamara Alempijevic
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Deficiency Anemia ◽  
Increased Risk ◽  
Disease Case ◽  
Wide Range ◽  
Life Threatening ◽  
Work Up

Celiac disease (CD) is a systemic, chronic autoimmune disease that occurs in genetically predisposed individuals following dietary gluten exposure. CD can present with a wide range of gastrointestinal and extraintestinal manifestations and requires lifelong adherence to a gluten-free diet [GFD]. Venous thromboembolism (VTE) as a presentation of celiac disease is unusual and rarely reported. We present a case of a 46-year-old man who was admitted for shortness of breath and pleuritic chest pain and was found to have iron deficiency anemia, deep venous thrombosis, and bilateral pulmonary emboli (PE). After work-up for his anemia, the patient was diagnosed with CD. Comprehensive investigation for inherited or acquired prothrombotic disorders was negative. It is becoming increasingly recognized that CD is associated with an increased risk for VTE. PE, however, as a presentation of CD is exceedingly rare and to the best of our knowledge this is the third case report of such an occurrence and the only case report of a patient from North America. It is important to recognize that the first symptoms or signs of celiac disease might be extraintestinal. Furthermore, VTE as a presentation of CD is rare but life-threatening.

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