Carboxypeptidase E regulates Activity-dependent TrkB Neuronal surface Insertion and Hippocampal memory

Journal of Neuroscience ◽

10.1523/jneurosci.0236-21.2021 ◽

2021 ◽

pp. JN-RM-0236-21

Author(s):

Na Li(娜李) ◽

Shuai-Wen Teng(文滕帅) ◽

Ling Zhao(玲赵) ◽

Jing-Rui Li(瑞李敬) ◽

Jia-Ling Xu(玲许佳) ◽

...

Keyword(s):

Carboxypeptidase E ◽

Activity Dependent

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Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E

Neuron ◽

10.1016/j.neuron.2004.12.037 ◽

2005 ◽

Vol 45 (2) ◽

pp. 245-255 ◽

Cited By ~ 110

Author(s):

Hong Lou ◽

Soo-Kyung Kim ◽

Eugene Zaitsev ◽

Chris R. Snell ◽

Bai Lu ◽

...

Keyword(s):

Carboxypeptidase E ◽

Sorting Receptor ◽

Activity Dependent

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Carboxypeptidase E Cytoplasmic Tail-Driven Vesicle Transport Is Key for Activity-Dependent Secretion of Peptide Hormones

Molecular Endocrinology ◽

10.1210/me.2007-0473 ◽

2008 ◽

Vol 22 (4) ◽

pp. 989-1005 ◽

Cited By ~ 35

Author(s):

Joshua J. Park ◽

Niamh X. Cawley ◽

Y. Peng Loh

Keyword(s):

Cytoplasmic Tail ◽

Peptide Hormones ◽

Vesicle Transport ◽

Carboxypeptidase E ◽

Activity Dependent

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Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

Zeitschrift für Neuropsychologie ◽

10.1024//1016-264x.12.1.8 ◽

2001 ◽

Vol 12 (1) ◽

pp. 8-14

Author(s):

Gertraud Teuchert-Noodt ◽

Ralf R. Dawirs

Keyword(s):

Prefrontal Cortex ◽

Mental Disorders ◽

Dentate Gyrus ◽

Cognitive Functions ◽

Experimental Approach ◽

Regulatory Mechanisms ◽

Hippocampal Dentate Gyrus ◽

Non Invasive ◽

Invasive Method ◽

Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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