scholarly journals Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 ◽  
Vol 18 (6) ◽  
pp. 2161-2173 ◽  
Author(s):  
Derik T. Weldon ◽  
Scott D. Rogers ◽  
Joseph R. Ghilardi ◽  
Matthew P. Finke ◽  
James P. Cleary ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Microglial Phagocytosis ◽  
Β Amyloid ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

2005 ◽  
Vol 202 (9) ◽  
pp. 1163-1169 ◽  
Author(s):  
Carl Nathan ◽  
Noel Calingasan ◽  
Jon Nezezon ◽  
Aihao Ding ◽  
M. Scott Lucia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Therapeutic Option ◽  
Premature Mortality ◽  
Transgenic Expression ◽  
Genetic Ablation ◽  
Β Amyloid ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis. Immunoreactive iNOS was detected in brains of mice with AD-like disease resulting from transgenic expression of mutant human β-amyloid precursor protein (hAPP) and presenilin-1 (hPS1). We bred hAPP-, hPS1-double transgenic mice to be iNOS+/+ or iNOS−/−, and compared them with a congenic WT strain. Deficiency of iNOS substantially protected the AD-like mice from premature mortality, cerebral plaque formation, increased β-amyloid levels, protein tyrosine nitration, astrocytosis, and microgliosis. Thus, iNOS seems to be a major instigator of β-amyloid deposition and disease progression. Inhibition of iNOS may be a therapeutic option in AD.

289: Roles of Inducible Nitric Oxide Synthase in Voiding Function and Bladder Pain During Experimental Cystitis

2006 ◽  
Vol 175 (4S) ◽  
pp. 96-96
Author(s):  
Masayoshi Nomura ◽  
Hisae Nishii ◽  
Masato Tsutsui ◽  
Naohiro Fujimoto ◽  
Tetsuro Matsumoto
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Voiding Function ◽  
Bladder Pain ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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