Altered Ca2+Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of Trisomy 16 Mice: A Model of Down’s Syndrome

Sebastian Schuchmann; Wolfgang Müller; Uwe Heinemann

doi:10.1523/jneurosci.18-18-07216.1998

Altered Ca2+Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of Trisomy 16 Mice: A Model of Down’s Syndrome

Journal of Neuroscience ◽

10.1523/jneurosci.18-18-07216.1998 ◽

1998 ◽

Vol 18 (18) ◽

pp. 7216-7231 ◽

Cited By ~ 52

Author(s):

Sebastian Schuchmann ◽

Wolfgang Müller ◽

Uwe Heinemann

Keyword(s):

Hippocampal Neurons ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16

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Long-term transplants of mouse trisomy 16 hippocampal neurons, a model for down's syndrome, do not develop Alzheimer's disease neuropathology

Brain Research ◽

10.1016/0006-8993(93)91413-m ◽

1993 ◽

Vol 610 (2) ◽

pp. 295-304 ◽

Cited By ~ 13

Author(s):

James Stoll ◽

Andrea Balbo ◽

Brian Ault ◽

Stanley I. Rapoport ◽

Alan Fine

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Hippocampal Neurons ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16

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Cultured hippocampal neurons from trisomy 16 mouse, a model for Down's syndrome, have an abnormal action potential due to a reduced inward sodium current

Brain Research ◽

10.1016/0006-8993(93)90353-o ◽

1993 ◽

Vol 604 (1-2) ◽

pp. 69-78 ◽

Cited By ~ 39

Author(s):

Z. Galdzicki ◽

E. Coan ◽

S.I. Rapoport

Keyword(s):

Action Potential ◽

Hippocampal Neurons ◽

Sodium Current ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16 ◽

Cultured Hippocampal Neurons

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The embryonic development of sensory organs and the skull in the trisomy 16 mouse, an animal model for Down's syndrome

Annals of Anatomy - Anatomischer Anzeiger ◽

10.1016/s0940-9602(97)80010-6 ◽

1997 ◽

Vol 179 (6) ◽

pp. 525-533 ◽

Cited By ~ 8

Author(s):

M. Ludwig ◽

L.C. Busch ◽

H. Winking

Keyword(s):

Animal Model ◽

Embryonic Development ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Sensory Organs ◽

Trisomy 16

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Long-term intracerebral transplants of fetal hippocampus from mouse trisomy 16, a model for Down's syndrome (trisomy 21), do not exhibit Alzheimer's disease neuropathology by ultrastructural criteria

Tissue and Cell ◽

10.1016/0040-8166(94)90001-9 ◽

1994 ◽

Vol 26 (4) ◽

pp. 477-488 ◽

Cited By ~ 4

Author(s):

Nancy J. Lane ◽

Andrea Balbo ◽

James Stoll ◽

Stanley I. Rapoport

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Trisomy 21 ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16

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Understanding mental retardation in Down's syndrome using trisomy 16 mouse models

Genes Brain & Behavior ◽

10.1034/j.1601-183x.2003.00024.x ◽

2003 ◽

Vol 2 (3) ◽

pp. 167-178 ◽

Cited By ~ 62

Author(s):

Z. Galdzicki ◽

R. J. Siarey

Keyword(s):

Mental Retardation ◽

Mouse Models ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16

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A FINE STRUCTURAL STUDY OF THE HIPPOCAMPUS AND DORSAL ROOT GANGLION IN MOUSE TRISOMY 16, A MODEL OF DOWN'S SYNDROME

Cell Biology International ◽

10.1006/cbir.1996.0089 ◽

1996 ◽

Vol 20 (10) ◽

pp. 673-680 ◽

Cited By ~ 9

Author(s):

N LANE

Keyword(s):

Dorsal Root Ganglion ◽

Structural Study ◽

Dorsal Root ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16

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Murine trisomy 16 model of Down's syndrome: Central nervous system electron microscopic observations

Brain Research Bulletin ◽

10.1016/0361-9230(89)90048-8 ◽

1989 ◽

Vol 22 (2) ◽

pp. 233-243 ◽

Cited By ~ 7

Author(s):

Audrius V. Plioplys ◽

H. Melanie Bedford

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Electron Microscopic ◽

Trisomy 16

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Selective retardation of the development of the basal forebrain cholinergic and pontine catecholaminergic nuclei in the brain of trisomy 16 mouse, an animal model of Down's syndrome

Developmental Brain Research ◽

10.1016/0165-3806(89)90201-0 ◽

1989 ◽

Vol 50 (2) ◽

pp. 251-264 ◽

Cited By ~ 20

Author(s):

J. Kiss ◽

M. Schlumpf ◽

R. Balázs

Keyword(s):

Animal Model ◽

Basal Forebrain ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16 ◽

The Brain

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Germ cell migration and early development of the gonads in the trisomy 16 mouse — an animal model for Down's syndrome

Annals of Anatomy - Anatomischer Anzeiger ◽

10.1016/s0940-9602(99)80039-9 ◽

1999 ◽

Vol 181 (3) ◽

pp. 247-252 ◽

Cited By ~ 7

Author(s):

Andreas Leffler ◽

Michael Ludwig ◽

Oliver Schmitt ◽

Lüder C. Busch

Keyword(s):

Animal Model ◽

Cell Migration ◽

Germ Cell ◽

Early Development ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Trisomy 16 ◽

Germ Cell Migration

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Decreased sensitivity to nerve growth factor of dorsal root ganglion neurons cultured from mouse trisomy 16, a model of Down's syndrome

Brain Research ◽

10.1016/0006-8993(95)00251-k ◽

1995 ◽

Vol 680 (1-2) ◽

pp. 108-116 ◽

Cited By ~ 6

Author(s):

Rosalyn Pearce ◽

Zygmunt Galdzicki ◽

Stanley I. Rapoport

Keyword(s):

Nerve Growth Factor ◽

Growth Factor ◽

Dorsal Root Ganglion ◽

Dorsal Root ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Dorsal Root Ganglion Neurons ◽

Nerve Growth ◽

Trisomy 16 ◽

Ganglion Neurons

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