scholarly journals Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

2002 ◽  
Vol 22 (5) ◽  
pp. 1763-1771 ◽  
Author(s):  
Du Chu Wu ◽  
Vernice Jackson-Lewis ◽  
Miquel Vila ◽  
Kim Tieu ◽  
Peter Teismann ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
Microglial Activation

Altered DAT function in a mouse model of Parkinson disease

2011 ◽  
Author(s):  
D. Leo ◽  
M. J. Bourque ◽  
C. Kortleven ◽  
E. A. Fon ◽  
L. E. Trudeau
Keyword(s):  
Mouse Model ◽  
Parkinson Disease

scholarly journals Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model

2021 ◽  
Vol 17 ◽  
pp. 174480692199093
Author(s):  
Dan-jie Su ◽  
Long-fei Li ◽  
Sai-ying Wang ◽  
Qi Yang ◽  
Yu-jing Wu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Mouse Model ◽  
Anterior Cingulate Cortex ◽  
Analgesic Effect ◽  
Microglial Activation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active ingredient derived from Peucedanum praeruptorum Dunn, traditionally used as antibechic, anti-bronchitis and anti-hypertension drug. Here, we evaluated the effects of Pra-C in a chronic inflammatory pain mouse model induced by complete Freund’s adjuvant (CFA) injection. Pra-C (3 mg/kg) treatment for just 3 days after CFA challenge relieved CFA-induced mechanical allodynia and hindpaw edema in mice. In the anterior cingulate cortex (ACC), Pra-C treatment inhibited microglia activation and reduced levels of proinflammatory cytokines, TNF-α and IL-1β, and suppressed upregulation of glutamate receptors caused by CFA injection. In addition, Pra-C attenuated neuronal hyperexcitability in ACC of CFA-injected mice. In vitro studies confirmed the analgesic effect of Pra-C was due to its inhibitory ability on microglial activation. In conclusion, Pra-C administration had a certain effect on relieving chronic pain by inhibiting microglial activation, attenuating proinflammatory cytokine releasing and regulating excitatory synaptic proteins in the ACC of the CFA-injected mice.

Slowing disease progression in the SOD1 mouse model of ALS by blocking neuregulin-induced microglial activation

2018 ◽  
Vol 111 ◽  
pp. 118-126 ◽  
Author(s):  
Jianguo Liu ◽  
Elise Allender ◽  
Jiajing Wang ◽  
Eleanor H. Simpson ◽  
Jeffrey A. Loeb ◽  
...  
Keyword(s):  
Mouse Model ◽  
Disease Progression ◽  
Microglial Activation ◽  
Sod1 Mouse

scholarly journals Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

2008 ◽  
Author(s):  
Vanessa Brochard ◽  
Béhazine Combadière ◽  
Annick Prigent ◽  
Yasmina Laouar ◽  
Aline Perrin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
The Brain ◽  
Cd4 Lymphocytes

scholarly journals Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease

2018 ◽  
Vol 56 (7) ◽  
pp. 5157-5166 ◽  
Author(s):  
Fanpeng Zhao ◽  
Sandra L. Siedlak ◽  
Sandy L. Torres ◽  
Qian Xu ◽  
Beisha Tang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
Neuronal Damage
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