scholarly journals One Week of Motor Adaptation Induces Structural Changes in Primary Motor Cortex That Predict Long-Term Memory One Year Later

2011 ◽  
Vol 31 (33) ◽  
pp. 11808-11813 ◽  
Author(s):  
S. M. Landi ◽  
F. Baguear ◽  
V. Della-Maggiore
Keyword(s):  
Motor Cortex ◽  
Structural Changes ◽  
Primary Motor Cortex ◽  
Motor Adaptation ◽  
Long Term Memory ◽  
Term Memory ◽  
One Year

scholarly journals Common Chord Progressions and Feelings of Remembering

2020 ◽  
Vol 3 ◽  
pp. 205920432091684
Author(s):  
Ivan Jimenez ◽  
Tuire Kuusi ◽  
Christopher Doll
Keyword(s):  
Popular Music ◽  
North American ◽  
Musical Training ◽  
The Other ◽  
Long Term Memory ◽  
Term Memory ◽  
One Year

Although Western tonal syntax can generate a very large number of chord successions of various lengths and degrees of complexity, some types of music, from Renaissance dances to recent pop, tend to rely more heavily on the repetition of relatively simple, short harmonic patterns. Doll recently identified short chord progressions commonly found in North American and British popular music and proposed that these chord progressions can be stored in long-term memory in the form of harmonic schemata that allow listeners to hear them as stereotypical chord progressions. However, considering the challenges that many listeners face when trying to consciously grasp harmony, it seems likely that the feelings of remembering chord progressions varies from listener to listener. To investigate these potential differences, we asked 231 listeners with various levels of musical training to rate their confidence on whether or not they had previously heard six diatonic four-chord progressions. To control for the effect of extra-harmonic features, we instantiated the chord progressions in a way that resembled the piano of a famous song and controlled for participants’ familiarity with that song and whether they had played its chords. We found that ratings correlated with typicality for the two groups of participants who had played an instrument for at least one year and to a lesser extent for the other participants. Additionally, all our players thought of specific songs more often and mentioned songs that better matched the stimuli in harmonic terms. What we did not find, however, was any effect associated to how long participants had played an instrument or the type of the instrument they had played. Our research supports the notion that both musical training and extra-harmonic features affect listeners’ feelings of remembering chord progressions.

Unwanted Memory Intrusions Recruit Broad Motor Suppression

2021 ◽  
Vol 33 (1) ◽  
pp. 119-128
Author(s):  
Anna Castiglione ◽  
Adam R. Aron
Keyword(s):  
Memory Retrieval ◽  
Primary Motor Cortex ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Long Term Memory ◽  
Second Phase ◽  
Unexpected Result ◽  
Term Memory ◽  
Rapid Action

Quickly preventing the retrieval of (inappropriate) long-term memories might recruit a similar control mechanism as rapid action-stopping. A very specific characteristic of rapid action-stopping is “global motor suppression”: When a single response is rapidly stopped, there is a broad skeletomotor suppression. This is shown by the technique of TMS placed over a task-irrelevant part of the primary motor cortex (M1) to measure motor-evoked potentials. Here, we used this same TMS method to test if rapidly preventing long-term memory retrieval also shows this broad skeletomotor suppression effect. Twenty human participants underwent a Think/No-Think task. In the first phase, they learned word pairs. In the second phase, they received the left-hand word as a cue and had to either retrieve the associated right-hand word (“Think”) or stop retrieval (“No-Think”). At the end of each trial, they reported whether they had experienced an intrusion of the associated memory. Behaviorally, on No-Think trials, they reported fewer intrusions than Think trials, and the reporting of intrusions decreased with practice. Physiologically, we observed that the motor-evoked potential, measured from the hand (which was irrelevant to the task), was reduced on No-Think trials in the time frame of 300–500 msec, especially on trials where they did report an intrusion. This unexpected result contradicted our preregistered prediction that we would find such a decrease on No-Think trials where the intrusion was not reported. These data suggest that one form of executive control over (inappropriate) long-term memory retrieval is a rapid and broad stop, akin to action-stopping, that is triggered by the intrusion itself.

scholarly journals Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER.

1992 ◽  
Vol 119 (5) ◽  
pp. 1069-1076 ◽  
Author(s):  
D Kuhl ◽  
T E Kennedy ◽  
A Barzilai ◽  
E R Kandel
Keyword(s):  
Protein Synthesis ◽  
Motor Neurons ◽  
Structural Changes ◽  
State Level ◽  
Long Term Memory ◽  
Major Protein ◽  
Synaptic Connections ◽  
Term Memory ◽  
Long Term Facilitation

Long-term memory for sensitization of the gill- and siphon-withdrawal reflexes in Aplysia californica requires RNA and protein synthesis. These long-term behavioral changes are accompanied by long-term facilitation of the synaptic connections between the gill and siphon sensory and motor neurons, which are similarly dependent on transcription and translation. In addition to showing an increase in over-all protein synthesis, long-term facilitation is associated with changes in the expression of specific early, intermediate, and late proteins, and with the growth of new synaptic connections between the sensory and motor neurons of the reflex. We previously focused on early proteins and have identified four proteins as members of the immunoglobulin family of cell adhesion molecules related to NCAM and fasciclin II. We have now cloned the cDNA corresponding to one of the late proteins, and identified it as the Aplysia homolog of BiP, an ER resident protein involved in the folding and assembly of secretory and membrane proteins. Behavioral training increases the steady-state level of BiP mRNA in the sensory neurons. The increase in the synthesis of BiP protein is first detected 3 h after the onset of facilitation, when the increase in overall protein synthesis reaches its peak and the formation of new synaptic terminals becomes apparent. These findings suggest that the chaperon function of BiP might serve to fold proteins and assemble protein complexes necessary for the structural changes characteristic of long-term memory.

CONTINUUM CLIMATE VARIABILITY: LONG-TERM MEMORY, SCALING, AND 1/F-NOISE

2009 ◽  
Vol 23 (28n29) ◽  
pp. 5403-5416 ◽  
Author(s):  
KLAUS FRAEDRICH ◽  
RICHARD BLENDER ◽  
XIUHUA ZHU
Keyword(s):  
General Circulation ◽  
General Circulation Models ◽  
Sea Surface ◽  
Long Term Memory ◽  
Sea Surface Temperatures ◽  
Term Memory ◽  
Ocean General Circulation Models ◽  
Ocean General Circulation ◽  
One Year

Continuum temperature variability represents the response of the Earth's climate to deterministic external forcing. Scaling regimes are observed which range from hours to millennia with low frequency fluctuations characterizing long-term memory. The presence of 1/f power spectra in weather and climate is noteworthy: (i) In the tropical atmosphere 1/f scaling ranging from hours to weeks is found for several variables; it emerges as superposition of uncorrelated pulses with individual 1/f spectra. (ii) The daily discharge of the Yangtze shows 1/f within one week to one year, although the precipitation spectrum is white. (iii) Beyond one year mid-latitude sea surface temperatures reveal 1/f scaling in large parts of the global ocean. The spectra can be simulated by complex atmosphere-ocean general circulation models and understood as a two layer heat diffusion process forced by an uncorrelated stochastic atmospheric. Long-term memory on time scales up to millennia are the global sea surface temperatures and the Greenland ice core records (GISP2, GRIP) with δ18 O temperature proxy data during the Holocene. Complex atmosphere ocean general circulation models reproduce this behavior quantitatively up to millennia without solar variability, interacting land-ice and vegetation components.

scholarly journals Formation of a long-term memory for visuomotor adaptation following only a few trials of practice

2015 ◽  
Vol 114 (2) ◽  
pp. 969-977 ◽  
Author(s):  
David M. Huberdeau ◽  
Adrian M. Haith ◽  
John W. Krakauer
Keyword(s):  
Human Subjects ◽  
Motor Adaptation ◽  
Visuomotor Adaptation ◽  
Reaching Movements ◽  
Motor Memory ◽  
Long Term Memory ◽  
Visuomotor Rotation ◽  
Initial Exposure ◽  
Term Memory

The term savings refers to faster motor adaptation upon reexposure to a previously experienced perturbation, a phenomenon thought to reflect the existence of a long-term motor memory. It is commonly assumed that sustained practice during the first perturbation exposure is necessary to create this memory. Here we sought to test this assumption by determining the minimum amount of experience necessary during initial adaptation to a visuomotor rotation to bring about savings the following day. Four groups of human subjects experienced 2, 5, 10, or 40 trials of a counterclockwise 30° cursor rotation during reaching movements on one day and were retested the following day to assay for savings. Groups that experienced five trials or more of adaptation on day 1 showed clear savings on day 2. Subjects in all groups learned significantly more from the first rotation trial on day 2 than on day 1, but this learning rate advantage was maintained only in groups that had reached asymptote during the initial exposure. Additional experiments revealed that savings occurred when the magnitude, but not the direction, of the rotation differed across exposures, and when a 5-min break, rather than an overnight one, separated the first and second exposure. The overall pattern of savings we observe across conditions can be explained as rapid retrieval of the state of learning attained during the first exposure rather than as modulation of sensitivity to error. We conclude that a long-term memory for compensating for a perturbation can be rapidly acquired and rapidly retrieved.

scholarly journals Long-Term Retention Explained by a Model of Short-Term Learning in the Adaptive Control of Reaching

2008 ◽  
Vol 100 (5) ◽  
pp. 2948-2955 ◽  
Author(s):  
Wilsaan M. Joiner ◽  
Maurice A. Smith
Keyword(s):  
Motor Adaptation ◽  
Memory Formation ◽  
Training Period ◽  
Long Term Memory ◽  
Initial Training ◽  
Short Term ◽  
Term Memory ◽  
Term Retention ◽  
Long Term Retention

Extensive theoretical, psychophysical, and neurobiological work has focused on the mechanisms by which short-term learning develops into long-term memory. Better understanding of these mechanisms may lead to the ability to improve the efficiency of training procedures. A key phenomenon in the formation of long-term memory is the effect of over learning on retention—discovered by Ebbinghaus in 1885: when the initial training period in a task is prolonged even beyond what is necessary for good immediate recall, long-term retention improves. Although this over learning effect has received considerable attention as a phenomenon in psychology research, the mechanisms governing this process are not well understood, and the ability to predict the benefit conveyed by varying degrees of over learning does not yet exist. Here we studied the relationship between the duration of an initial training period and the amount of retention 24 h later for the adaptation of human reaching arm movements to a novel force environment. We show that in this motor adaptation task, the amount of long-term retention is predicted not by the overall performance level achieved during the training period but rather by the level of a specific component process in a multi-rate model of short-term memory formation. These findings indicate that while multiple learning processes determine the ability to learn a motor adaptation, only one provides a gateway to long-term memory formation. Understanding the dynamics of this key learning process may allow for the rational design of training and rehabilitation paradigms that maximize the long-term benefit of each session.

scholarly journals Persistent increases of PKMζ in sensorimotor cortex maintain procedural long-term memory storage

2017 ◽  
Author(s):  
Peng P. Gao ◽  
Jeffrey H. Goodman ◽  
Todd C. Sacktor ◽  
Joseph T. Francis
Keyword(s):  
Sensorimotor Cortex ◽  
Primary Motor Cortex ◽  
Long Term Potentiation ◽  
Synaptic Strength ◽  
Procedural Memory ◽  
Memory Storage ◽  
Long Term Memory ◽  
Term Memory ◽  
Atypical Pkc

SummaryProcedural memories, such as for riding a bicycle, can be maintained without practice for long periods of time and are thought to be supported by the persistent reorganization of sensorimotor cortices (S1/M1). Whereas enhanced synaptic strength and structural changes accompany the learning of motor tasks, the persistent molecular modifications that store long-term procedural memories within specific layers of sensorimotor cortex have not been identified. The persistent increase in the autonomously active, atypical PKC isoform, PKMζ, is a putative molecular mechanism for maintaining enhanced synaptic strength during long-term potentiation (LTP) and several forms of long-term memory. Here we examine whether persistent increases in PKMζ store long-term memory for a reaching task in rat sensorimotor cortex that could reveal the sites of procedural memory storage. Perturbing PKMζ synthesis with PKMζ -antisense oligodeoxynucleotides or blocking atypical PKC activity with zeta inhibitory peptide (ZIP) in S1/M1 disrupts and erases the maintenance of long-term motor memories. Only memories that are maintained without daily reinforcement are affected, indicating atypical PKCs (via ZIP) and PKMζ specifically (via antisense) stores consolidated long-term procedural memories. Analysis of changes in the amount of PKMζ in S1/M1 reveals PKMζ increases in layers II/III and V of both S1 and M1 cortices as performance improves to an asymptote during training. After storage for 1 month without reinforcement, the increase in M1 layer V but not other layers persists without decrement. Thus, the sustained increases in PKMζ reveal that the persistent molecular changes storing long-term procedural memory are localized to the descending output layer of primary motor cortex.

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