scholarly journals Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies

2020 ◽  
Vol 12 (12) ◽  
Author(s):  
SungWoo Choi ◽  
Giulia Ferrari ◽  
Francesco Saverio Tedesco
Keyword(s):  
Skeletal Muscle ◽  
Cell Migration ◽  
Muscle Cell ◽  
Molecular Mechanisms ◽  
Skeletal Muscle Cell ◽  
Myogenic Cell ◽  
Cellular Dynamics ◽  
Cell Therapies

scholarly journals Platelet rich plasma promotes skeletal muscle cell migration in association with up-regulation of FAK, paxillin, and F-Actin formation

2017 ◽  
Vol 35 (11) ◽  
pp. 2506-2512 ◽  
Author(s):  
Wen-Chung Tsai ◽  
Tung-Yang Yu ◽  
Li-Ping Lin ◽  
Mioa-Sui Lin ◽  
Ting-Ta Tsai ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Migration ◽  
Muscle Cell ◽  
Platelet Rich Plasma ◽  
Skeletal Muscle Cell

scholarly journals Annexin A1 Induces Skeletal Muscle Cell Migration Acting through Formyl Peptide Receptors

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48246 ◽  
Author(s):  
Valentina Bizzarro ◽  
Raffaella Belvedere ◽  
Fabrizio Dal Piaz ◽  
Luca Parente ◽  
Antonello Petrella
Keyword(s):  
Skeletal Muscle ◽  
Cell Migration ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Annexin A1 ◽  
Peptide Receptors ◽  
Formyl Peptide Receptors ◽  
Formyl Peptide

scholarly journals Generation and Characterization of Skeletal Muscle Cell based Model for GNE Myopathy: Implications in Actin Dynamics

2020 ◽  
Author(s):  
Shamulailatpam Shreedarshanee Devi ◽  
Rashmi Yadav ◽  
Fluencephila Mashangva ◽  
Priyanka Chaudhary ◽  
Shweta Sharma ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Migration ◽  
Sialic Acid ◽  
Muscle Cell ◽  
Model System ◽  
Skeletal Muscle Cell ◽  
Actin Dynamics ◽  
Knock Out ◽  
Gne Myopathy ◽  
Gne Gene

Abstract UDP-N-acetyl glucosamine-2 epimerase/ N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid. Mutation in GNE gene causes GNE-Myopathy characterized by adult onset muscle weakness and degeneration. GNE is involved in different cellular processes like adhesion, apoptosis, ER stress and autophagy. Lack of appropriate model system limits drug and treatment options for GNE Myopathy as GNE knock out was found to be embryonically lethal. In the present study, we have generated L6 rat skeletal muscle cell-based model system for GNE Myopathy where GNE gene is knocked out at exon 3 using AAV mediated SEPT homology recombination. The cell line was heterozygous for GNE gene with one wild type and one truncated allele as confirmed by sequencing. The phenotype showed reduced GNE epimerase activity with little reduction in sialic acid content. In addition, the GNE knock out cell line revealed altered cytoskeletal organization with disrupted actin filament. The signaling cascade regulating actin dynamics such as Rho A, Cofilin, FAK and Src were altered leading to reduced cell migration in GNE heterozygous cells. Our study indicates possible role of GNE in regulating actin dynamics and cell migration of skeletal muscle cell. The skeletal muscle cell based system offers great potential in understanding pathomechanism and target identification for GNE Myopathy.

Skeletal muscle cell transplantation: models and methods

2019 ◽  
Vol 41 (4) ◽  
pp. 297-311 ◽  
Author(s):  
Amber L. Mueller ◽  
Robert J. Bloch
Keyword(s):  
Skeletal Muscle ◽  
Cell Transplantation ◽  
Muscle Cell ◽  
Skeletal Muscle Cell

THE MYOGRAM OF THE ISOLATED SKELETAL MUSCLE CELL

Science ◽  
1930 ◽  
Vol 72 (1853) ◽  
pp. 17-18 ◽  
Author(s):  
D. E. S. Brown ◽  
F. J. M. Sichel
Keyword(s):  
Skeletal Muscle ◽  
Muscle Cell ◽  
Skeletal Muscle Cell
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