Mechanistic Validation of an Ergogenic T. arjuna Standardized Extract (Oxyjun®) Using a Molecular Docking Approach

The bark of the tree Terminalia arjuna commonly referred as Arjuna is widely used in Ayurveda as a therapeutic agent for heart disease. More recently, a proprietary botanical extract of T. arjuna with tradename, Oxyjun®, demonstrated cardiotonic and ergogenic benefits for the first time in a younger and healthier population. However, the mechanism of action and biological actives of this novel sports ingredient were not clear. A molecular docking approach was adopted to understand the protein-ligand interactions and establish the most probable mechanism(s) of cardio vascular actions of the phytoconstituents of the T. arjuna standardized extract (TASE). Twenty-one phytochemicals (ligands) were chosen from Arjuna and their binding affinities against eight proteins serving cardiovascular functions (target proteins) were investigated. Autodock Vina was used to carry out the molecular docking studies. Potential efficacy in humans was assessed on the basis of ADMET properties and Lipinski’s Rule of 5. We found that arjunic acid, arjungenin, arjunetin, arjunglucoside1, chrysin, kaempferol, luteolin, rhamnetin and taxifolin demonstrated good docking scores and bioactivity.

Essential Oils and Their Individual Components in Cosmetic Products

The current consumer demands together with the international regulations have pushed the cosmetic industry to seek new active ingredients from natural renewable sources for manufacturing more eco-sustainability and safe products, with botanical extract being an almost unlimited source of these new actives. Essential oils (EOs) emerge as very common natural ingredients in cosmetics and toiletries as a result of both their odorous character for the design and manufacturing of fragrances and perfumes, and the many beneficial properties of their individual components (EOCs), e.g., anti-inflammatory, antimicrobial and antioxidant properties, and, nowadays, the cosmetic industry includes EOs or different mixtures of their individual components (EOCs), either as active ingredients or as preservatives, in various product ranges (e.g., moisturizers, lotions and cleanser in skin care cosmetics; conditioners, masks or antidandruff products in hair care products; lipsticks, or fragrances in perfumery). However, the unique chemical profile of each individual essential oil is associated with different benefits, and hence it is difficult to generalize their potential applications in cosmetics and toiletries, which often require the effort of formulators in seeking suitable mixtures of EOs or EOCs for obtaining specific benefits in the final products. This work presents an updated review of the available literature related to the most recent advances in the application of EOs and EOCs in the manufacturing of cosmetic products. Furthermore, some specific aspects related to the safety of EOs and EOCs in cosmetics will be discussed. It is expected that the information contained in this comprehensive review can be exploited by formulators in the design and optimization of cosmetic formulations containing botanical extracts.

A fat-promoting plant extract from Artemisia scoparia exerts geroprotective effects on C. elegans health & lifespan

Like other biological processes, aging is not random, but subject to molecular control. Natural products that act on conserved metabolic pathways may provide entry points to extend animal lifespan and promote healthy aging. Here, we show that a botanical extract from Artemisia scoparia (SCO), which promotes fat storage and metabolic resiliency in mice, exerts pro-longevity effects on the nematode Caenorhabditis elegans, even when administered in mid-adulthood. SCO-treated worms exhibit significantly higher levels of fat compared to controls but live up to 40% longer, with signs of improved stress resistance in late age. Molecularly, SCO links elevated fat to enhanced longevity and stress resistance via activation of the transcription factor DAF-16/FOXO and upregulation of DAF-16-targeted Δ9 desaturases, lifespan-extending metabolic enzymes that oversee the biosynthesis of monounsaturated fatty acids. These findings identify SCO as a natural product that can modify fat regulation for longevity benefit and add to growing evidence indicating that elevated fat can be pro-longevity in some circumstances.

Plant Material as a Novel Tool in Designing and Formulating Modern Biostimulants—Analysis of Botanical Extract from Linum usitatissimum L.

Nowadays, researchers are looking into next-generation biostimulants that can be designed as a dedicated agronomic tool based on plant materials. The aim of the present study was to develop a novel biostimulating product, based on plant material in the form of linseed aqueous extracts. The scope of the research included the physicochemical characterization of the product and identification of its biostimulating potential. The study has confirmed that the plant biostimulant derived from L. usitatissimum can be used as a viable agronomic tool for growing soybean. The designed and produced biostimulant is rich in bioactive compounds, including amino acids, free fatty acids, carbohydrates, and micro- and macroelements. The tested biostimulant showed significantly lower values of surface tension in relation to water and a commercial biostimulant. The soybean crops responded to the application of the preparation by improvements in agronomic and morphological levels. The linseed macerates were effective in terms of soybean yields and profitability. Our findings serve as preliminary evidence for the viability of designing and developing novel biostimulants derived from plant materials. This comprehensive approach to designing and formulating novel bioproducts necessitates more extensive and targeted research to fully explain the mechanisms behind the improvements observed in the soybean cultivation.

291 Weaned Holstein Calves Fed an Experimental Botanical Extract Alone or in Combination with an Eubiotic Product

A botanical extract (BE; garlic oil, anise oil, cinnamaldehyde, rosemary, and thyme blend) has been shown to enhance dry matter intake (DMI) and gut health, while eubiotics (EU; lactobacillus acidophilus fermentation product), has been shown to improve gut health and growth performance of growing Holstein calves. The hypothesis was the combination BE and EU could be synergistic to post-weaning neonatal calf growth performance. Seventy-seven (77) Holstein bull calves from a previous milk replacer trial were randomly assigned to 1 of 4 treatments using a 3 wk experimental period. Treatments were: 1) Control: Calf starter (CS) without BE or EU; 2) BE: CS with 275.6 g/ton of an experimental BE (Adisseo North America, Alpharetta, GA); 3) EU: CS with 0.22% EU (RumaCell DF 5G; Pacer Technology, Murtaugh, ID); and 4) BE&EU: CS with added BE and EU. The 22% crude protein CS was a mini-pellet and fed for ad-libitum consumption with amounts fed and orts recorded daily. Calves fed EU demonstrated greater (P < 0.05) body weight (BW; 81.3, 80.8, 84.8, and 84.2 kg for Control, BE, EU, and BE&EU, respectively) compared with calves fed Control and BE with calves fed BE&EU being intermediate and similar (P > 0.10). Calves fed BE demonstrated greater (P < 0.05) average daily gains (ADG; 965.5, 984.3, 1052.8 and 989.1 g/d) compared with calves fed Control with calves fed BE and BE&EU being intermediate and similar (P > 0.10). The DMI (2.19, 2.18, 2.31, and 2.14 kg/d) and feed conversions (0.45, 0.46, 0.45, and 0.45 kg BW gain/kg DMI) were similar (P > 0.10) among calves fed all treatments. Blood urea nitrogen concentrations (14.7, 14.6, 14.9, and 13.4 mg/dL) were similar (P > 0.10) among calves fed all treatments. Feeding a EU improved BW of weaned growing Holstein bull calves, but the BE and EU combination was not beneficial for enhancing growth performance.

Management of Root-knot Nematode Meloidogyne incognita on Mulberry with Passiflora foetida

Background: The root knot nematode Meloidogyne incognita Chit wood infesting mulberry is economically important in silk industry as it affects the leaf yield both quantitatively and qualitatively which in turn affects the silkworm Bombyx mori L., growth and cocoon yield because its foliage is the sole food source of silkworm. Methods: Hence a pot experiment was conducted for the evaluation of efficacy of eco-friendly formulate like botanical extract from Passiflora foetida L., to manage nematode disease severity applied as soil amendment and aqueous leaf extract on nematode egg hatching. Result: After treatment, nematode infestation reduced significantly in terms of number of root knots/ g root weight and nematode egg masses / g root weight in mulberry plants and the treated plants showed better growth in shoot and root length compared to control plants. The aqueous extract of P. foetida showed maximum inhibition of egg hatchability with an increase in the concentration of plant extract.

Beneficial Effects of Plant Extracts and Bioactive Food Components in Childhood Supplementation

The pivotal role of childhood nutrition has always roused a growing interest from the scientific community. Plant extracts and bioactive dietary components play a significant role in the maintenance of human health and wellness, with the potential to modulate risk factors and manage symptoms for a large number of common childhood disorders such as memory impairment, respiratory illnesses, gastrointestinal disorders, metabolic derangements, and pathologies related to the oral cavity. This review is designed to highlight the health benefits of botanical extracts and bioactive dietary components in children as evidenced by clinical trials, considering their safety with regards to childhood sensibilities. The supplementation of children with the herbal extracts or bioactive components mentioned in this review leads to the conclusion that they are useful for treating various ailments, with no serious adverse events being reported. However, for the limited number of investigations specifically focused on the safety of such products in children, time is needed to expand the literature data covering the safety of childhood supplementation with botanical extract and bioactive food components.

Identification of a Biostimulating Potential of an Organic Biomaterial Based on the Botanical Extract from Arctium lappa L. Roots

The development of novel biomaterials based on plant extracts is expected to boost yields without adversely affecting environmental diversity. The potential biostimulating effects have so far been underreported. The assessment of the stimulating effect of botanical biomaterials is essential in the cultivation of economically-important crops. An attempt was undertaken in this study to develop a new biostimulating material in the form of granules, based on an extract from the roots of Arctium lappa L. The scope of the research included the characterization of the new material and the identification of its biostimulating potential. The designed and produced biogranulate is rich in bioactive compounds, including polyphenolic compounds, carbohydrates, and micro- and macro-elements. The analysis of the physicochemical properties of the biomaterial has shown that it had the features of intelligent biopreparations, i.e., slow-release preparations, at the pH appropriate for legume plants. Thus, knowledge about the design of new biomaterials is a milestone in the practical development of new perspectives for enhancing sustainability in agriculture.