scholarly journals Blood Biochemical Parameters In Yakut Women With Type 2 Diabetes Mellitus Versus Their Somatotypes

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Alla B. Guryeva ◽  
Vilyuia A. Alekseyeva
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Biochemical Parameters ◽  
Body Type ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Reference Limits ◽  
Body Index

Objective — Investigating the features of blood biochemical parameters in patients with type 2 diabetes mellitus (DM2), depending on the somatotype sensu the Rees-Eysenck body index. Material and methods — We examined 88 women of Yakut nationality (39-74 years old) with an established diagnosis of DM2. An anthropometric examination with consequent somatotyping according to the Rees-Eysenck body index, along with determination of BMI were carried out. The biochemical blood test results were copied from the anamneses of female subjects. Statistical analysis was performed using the SPSS Statistics software package for Windows (version 17). Methods of parametric and nonparametric statistics were used. Results — We established that the anthropometric parameters and BMI of women with DM2 were significantly higher. According to the BMI gradation, obesity was more common in people with DM2. The results of somatotyping implied that 11.4%, 50.0% and 38.6%of the examined women belonged to the asthenic, normosthenic and pyknic somatotypes, correspondingly. The distribution of somatotypes among women with DM2 differed from the general population distribution in a smaller fraction of individuals with asthenic somatotype. Blood biochemical parameters in subjects with asthenic body type were within the reference limits (except for glucose), in contrast to those of women with other somatotypes. Conclusion — Women with asthenic somatotype are less at risk of developing DM2. Even if the ailment develops, their blood biochemical parameters remain within reference limits, with the exception of glucose.

scholarly journals Insulin Resistance (IR) in Patients with Type 2 Diabetes Mellitus. Identifying Predictors of Insulin Resistance and Establishing a Correlation Between Insulin Resistance and Cardiovascular Risk

2018 ◽  
Vol 15 (2) ◽  
pp. 7-15
Author(s):  
Vesa Cosmin Mihai ◽  
Popa Loredana ◽  
Daina Lucia ◽  
Moisi Mădălina ◽  
Popescu Mircea ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Biochemical Parameters ◽  
Diabetes Development ◽  
Effect Of Age ◽  
Determinant Factor

AbstractInsulin resistance is a determinant factor for the increased prevalence of hypertension and dyslipidemia in type 2 diabetes patients. In this study we determined those modifications of clinical and biochemical parameters associated with insulin resistance in the diabetic patient, these alterations can offer us indications concerning the pathophysiological mechanisms that lead to the diabetes development in the case of most patients. Also we determined a correlation between insulin resistance and cardiovascular risk, through the combined effect of age and insulin resistance on this risk.

Association of NFκβ, TNFα, IL-6, IL-1β, and LPL Polymorphisms with Type 2 Diabetes Mellitus and Biochemical Parameters in a Mexican Population

2021 ◽  
Author(s):  
O. C. Martínez-Ramírez ◽  
D. A. Salazar-Piña ◽  
Ramos-García M. de Lorena ◽  
C. Castro-Hernández ◽  
L. Casas-Ávila ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Biochemical Parameters ◽  
Mexican Population

scholarly journals Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment

2009 ◽  
pp. 93-99 ◽  
Author(s):  
M Haluzík ◽  
K Anderlová ◽  
R Doležalová ◽  
A Adamíková ◽  
D Haluzíková ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Biochemical Parameters ◽  
Fatty Acid Binding ◽  
Fenofibrate Treatment ◽  
Before And After

Recent studies have demonstrated that adipocyte fatty acid binding proteins (FABP) may play a role in the etiopathogenesis of insulin resistance. The aim of our study was to assess serum FABP levels in obese patients with type 2 diabetes mellitus (T2DM) before and after 3 months of treatment with PPAR-α agonist fenofibrate (F) and to explore the relationship of FABP to biochemical parameters and measures of insulin sensitivity assessed by hyperinsulinemic-isoglycemic clamp. We measured biochemical parameters by standard laboratory methods, insulin sensitivity by hyperinsulinemic-isoglycemic clamp and serum concentrations of FABP by commercial ELISA kit in 11 obese females with T2DM before and after three months of treatment with PPAR-α agonist fenofibrate and in 10 lean healthy control women (C). Serum FABP levels were 2.5-fold higher in T2DM group relative to C and were not affected by fenofibrate treatment (C: 20.6±2.1 μg/l, T2DM before F: 55.6±5.7 μg/l, T2DM after F: 54.2±5.4 μg/l, p<0.0001 for C vs. T2DM before F). Hyperinsulinemia during the clamp significantly suppressed FABP levels in both C and T2DM group. FABP levels positively correlated with BMI, triglyceride levels, blood glucose, glycated hemoglobin, atherogenic index and insulin levels. An inverse relationship was found between FABP and HDL levels, metabolic clearance rate of glucose, M/I and MCRglc/I sensitivity indexes. We conclude that FABP levels are closely related to BMI, parameters of insulin sensitivity, HDL levels and measures of diabetes compensation. This combination makes FABP a valuable marker of metabolic disturbances in patients with type 2 diabetes mellitus.

scholarly journals Study of glycemic gap in hyperglycemic emergencies of type 2 diabetes mellitus

2018 ◽  
Vol 6 (4) ◽  
pp. 1151
Author(s):  
Periyasamy Sivakumar ◽  
Thiyagarajan Manjuladevi Moonishaa ◽  
Neethu George
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Biochemical Parameters ◽  
Plasma Osmolality ◽  
Study Groups ◽  
Hyperosmolar Hyperglycemic State ◽  
Study Population ◽  
The Relationship

Background: Type 2 diabetes mellitus (T2DM) is associated with two serious hyperglycemic emergencies namely Diabetic ketoacidosis (DKA) and Hyperosmolar hyperglycemic state (HHS). The aim of the study was to determine the usefulness of glycemic gap in T2DM patients with DKA and HHS.Methods: T2DM cases above 20 years of age were included in this study. The study population was divided into three broad groups as T2DM without hyperglycemic emergencies, T2DM with DKA, T2DM with HHS, with 50 subjects in each group. Glycemic gap was calculated in the study population and compared between the three groups. The relationship between glycemic gap and the conventional indicators of severity in hyperglycemic emergencies of T2DM were determined.Results: Of the three study groups, T2DM cases with HHS presented with substantial alterations in the baseline biochemical parameters. The glycemic gap was also highly elevated in the HHS cases than the others. Glycemic gap showed significant correlation only with plasma osmolality of the HHS cases.Conclusions: Elevated glycemic gap indicating stress induced hyperglycemia (SIH) occur in hyperglycemic emergencies of T2DM, especially HHS. 

A Comparative assessment of Metabolic Syndrome and its association with Vitamin D and other risk factors in Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Ammar Abdulrahman Jairoun ◽  
Moyad Jamal Shahwan ◽  
Mohammed Husham Khattab
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diagnostic Criteria ◽  
Biochemical Parameters ◽  
World Health ◽  
Diabetic Patients

Objectives: To determine the overall prevalence of metabolic syndrome using World health organization (WHO); National Cholesterol Education program (NCEP) and International diabetes federation (IDF) guidelines and to study its association with vitamin D and other biochemical parameters in patients with type 2 Diabetes mellitus, as well as to identify the set of biochemical parameters that jointly influence the metabolic syndrome using different diagnostic criteria. Methods: A cross-sectional study was carried out at private health care center. A total of 291 diabetic patients. Sociodemographic, clinical, and laboratory data were obtained from the medical records of patients. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS, version 23). Results: A total number of 291 patients with T2DM were included in this study. The overall prevalence of metabolic syndrome among the study subjects was 48.1%, 87.3%, 64.9% using WHO, IDF and NCEP-ATPIII criteria respectively. The highest prevalence was reported following IDF diagnostic criteria. Sex, triglyceride and fasting blood sugar were associated factors of metabolic syndrome by all the three diagnostic criteria of metabolic syndrome. Conclusion: the study revealed high prevalence rate of metabolic syndrome among type 2 diabetic patients, which was highest 87.3% according to IDF and lowest was observed in WHO criteria 48.1%. A significant variance in the prevalence of metabolic syndrome was reported between WHO, IDF and NCEP criteria.

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