Blood Ethanol Levels Following Rapid Intravenous Infusion

The article presents the results of a study of the effectiveness of the use of an inhibitor of pancreatic enzyme secretion of octreotide (Octrade) for the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). It was shown that the administration of Octrade at a dose of 0.3 mg in 500 ml of 0.9 % NaCl by continuous intravenous infusion for 7 hours and then 0.1 mg of Octrade subcutaneously at 6 and 12 hours after the end of intravenous infusion significantly reduced the frequency of pancreatitis (4.0 % and 22.2 %; p < 0.05) and hyperamylasemia (8.0 % and 25.9 %; p < 0.05) after ERCP. It is concluded that Octrade is effective in preventing the development of pancreatitis and hyperamilasemia after ERCP.

Download Full-text

IMITATION OF THE ADRENO-CORTICAL RESPONSE TO SURGERY BY INTRAVENOUS INFUSION OF SYNTHETIC HUMAN ACTH

Acta Endocrinologica ◽

10.1530/acta.0.0720075 ◽

1973 ◽

Vol 72 (1) ◽

pp. 75-80

Author(s):

Henrik Kehlet ◽

Christian Binder ◽

Christen Engbæk

Keyword(s):

Intravenous Infusion ◽

Time Course ◽

Cortical Response ◽

Secretion Rate ◽

Major Surgery ◽

Acth Secretion ◽

Dose Rates

ABSTRACT The concentration of plasma corticosteroids was followed during major surgery and during the infusion of synthetic human ACTH at dose rates varying from 2400 ng to 15 000 ng per hour. The results showed that the time course of plasma corticosteroids during major surgery was intermediate between that obtained during the infusion of 7500 and 15 000 ng synthetic human ACTH per hour. This gives an estimated ACTH secretion rate during major surgery of between 7500 ng and 15 000 ng per hour.

Download Full-text

ADRENERGIC CONTROL MECHANISM FOR ACTH SECRETION IN MAN

Acta Endocrinologica ◽

10.1530/acta.0.0740263 ◽

1973 ◽

Vol 74 (2) ◽

pp. 263-270 ◽

Cited By ~ 50

Author(s):

Yoshikatsu Nakai ◽

Hiroo Imura ◽

Teruya Yoshimi ◽

Shigeru Matsukura

Keyword(s):

Intravenous Infusion ◽

Human Subjects ◽

Blocking Agent ◽

Inhibitory Effect ◽

Plasma Acth ◽

Acth Secretion ◽

Glucose Levels ◽

Alpha Receptors ◽

Normal Human ◽

Adrenergic Blocking

ABSTRACT In order to determine if an adrenergic mechanism is involved in the secretion of corticotrophin (ACTH), the effect of adrenergic-blocking or -stimulating agent on plasma ACTH, cortisol and glucose levels was studied in normal human subjects. The intravenous infusion of methoxamine, an alpha adrenergic-stimulating agent, caused a rise in plasma ACTH and cortisol. This increase in plasma ACTH and cortisol was significantly inhibited by the simultaneous administration of phentolamine, an alpha adrenergic-blocking agent, in combination with methoxamine. The intravenous infusion of propranolol, a beta adrenergic-blocking agent, caused no significant change in plasma ACTH and cortisol, although it enhanced the plasma ACTH response to insulin-induced hypoglycaemia. On the other hand, alpha adrenergicblockade by intravenous infusion of phentolamine significantly suppressed the plasma ACTH response to insulin-induced hypoglycaemia. These studies suggest a stimulatory effect of alpha receptors and a possible inhibitory effect of beta receptors on ACTH secretion in man.

Download Full-text

ÜBER DIE WIRKUNG PHARMAKOLOGISCHER OXYTOCINDOSEN AUF DIE MILCHDRÜSE

Acta Endocrinologica ◽

10.1530/acta.0.xxxiv0543 ◽

1960 ◽

Vol XXXIV (IV) ◽

pp. 543-557 ◽

Cited By ~ 12

Author(s):

B. Berde ◽

A. Cerletti

Keyword(s):

Mammary Gland ◽

Intravenous Administration ◽

Intravenous Infusion ◽

Intranasal Administration ◽

Intramuscular Injection ◽

Different Types ◽

Lactating Mammary Gland ◽

Synthetic Oxytocin

ABSTRACT A study was made of the influence of pharmacological amounts of synthetic oxytocin (»Syntocinon«) on the lactating mammary gland of the rabbit. The drug was given by intravenous infusion, by intramuscular injection and by intranasal administration. Two different types of reaction were noted: a tonic reaction, i. e. a lasting increase in pressure in the mammary gland without significant fluctuations, or a rhythmic reaction, i. e. a series of increases in pressure at more or less regular intervals. In order to elicit reactions approximately identical in intensity and character with those produced by intravenous infusion, it was necessary to give approximately 1.5 to 8.0 times as much by intramuscular injection and approximately 10 to 100 times as much by intranasal administration. Intravenous administration of adrenaline transiently suppressed a long-lasting reaction to oxytocin.

Download Full-text