PERINATAL MORTALITY IN DIABETIC PREGNANCY

1961 ◽  
Vol 37 (3) ◽  
pp. 434-440 ◽  
Author(s):  
Ebbe Brandstrup ◽  
Mogens Osler ◽  
Jørgen Pedersen
Keyword(s):  
Birth Weight ◽  
Perinatal Mortality ◽  
Neonatal Period ◽  
Diabetic Mother ◽  
Point Of View ◽  
Diabetic Pregnancy ◽  
Ideal Weight ◽  
Length Of Treatment ◽  
Birth Weight Group ◽  
The Ideal

ABSTRACT The length of treatment in the ward during the latter part of pregnancy has a considerable influence on the perinatal mortality in diabetic pregnancy. Thus, in the present New Series (1946–1960) comprising 486 babies the mortality decreased from 29 to 18 and 12 per cent respectively, when the series was divided in three groups with increasing length of treatment in hospital. The prognosis for the baby born of a diabetic mother is best in the foetal age group 252–266 days and the birth weight group 3500–3950 g. In the total series of 643 babies (1926–1960) 106 babies fulfilled both criteria, and only one of these babies died. The good result in this group did not depend on the length of treatment during the later part of pregnancy, in contradistinction to the mortality outside the favourable group. An attempt to define maternal factors which might determine the baby being born just with the ideal weight and age was unsuccessful. At the present the cause of the low »inborne« mortality of this group is unknown. From a practical point of view it is of interest that whenever a baby of a diabetic mother is born with a foetal age of 252–266 days and a birth weight of 3500–3950 g it is practically certain that it will not die during the neonatal period.

PROGNOSIS OF THE OUTCOME OF PREGNANCIES IN DIABETICS

1965 ◽  
Vol 50 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Jørgen Pedersen ◽  
Lars Mølsted Pedersen
Keyword(s):  
Perinatal Mortality ◽  
Poor Prognosis ◽  
Point Of View ◽  
Premature Delivery ◽  
Consecutive Series ◽  
Length Of Treatment ◽  
The Poor ◽  
Pregnancy In Diabetics ◽  
Weight Groups

ABSTRACT In order to improve the possibilities of predicting the outcome of pregnancy in diabetics, we analysed a consecutive series of 304 pregnancies in 263 diabetic women in the Royal Maternity Department B, Rigshospitalet, Copenhagen, during the 5-year period 1959-1963. The period of supervision and treatment during pregnancy varied greatly. The perinatal mortality in the 306 infants was 17.9%. According to the results of this analysis, patients with a poor prognosis were divided into the following four groups: Pregnant women who developed (1) hyperpyretic pyelitis, (2) pre-coma or severe acidosis, (3) toxaemia, or patients who could be so described, (4) »neglectors« These four groups, and the classification, are designated PBSP (Prognostically Bad Signs during Pregnancy). The mothers of 130 infants belonged to one or more of the four groups of PBSP, and among the infants of these mothers the perinatal mortality was 31.5% as compared with 7.9% in the group of 176 infants without PBSP during pregnancy. The poor prognosis for the pregnancies with PBSP applies to all foetal weight groups. In addition, these pregnancies terminate in premature delivery twice as often as the others. It is demonstrated that from the prognostic point of view, nothing is gained by including hydramnios in PBSP. The risk involved by a PBSP complication to the foetus depends on the White (1949) class in which it occurs. A combination of White's classification of pregnant diabetics with regard to foetal prognosis used together with the present classification improves the possibility of predicting the foetal prognosis in a series of pregnant diabetics which is mixed as regards the length of treatment during pregnancy.

scholarly journals Association of Low Birth Weight Infants and Maternal Sociodemographic Status in Tuzla Canton during 1992–1995 War Period in Bosnia and Herzegovina

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Fahrija Skokić ◽  
Dubravka Bačaj ◽  
Amela Selimović ◽  
Evlijana Hasanović ◽  
Selma Muratović ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Incidence Rate ◽  
Perinatal Mortality ◽  
Bosnia And Herzegovina ◽  
Low Birth Weight Infants ◽  
Live Births ◽  
Early Neonatal Mortality ◽  
Birth Weight Group

Objectives. We examined association between incidence rate of low birth weight in liveborn infants and maternal sociodemographic status in Tuzla Canton during 1992–1995 war in Bosnia and Herzegovina.Methods. The present study covers a 22-year period (1988–2009), including the war period (1992–1995), and we retrospectively collected data on a total of 108 316 liveborn infants and their mothers from three different socioeconomic periods: before (1988–1991), during (1992–1995), and after the war (1996–2009). Association between incidence rate of low birth weight in liveborn infants and maternal sociodemographic status were determined for each study period.Results. There were 23 194 live births in the prewar, 18 302 during the war, and 66 820 in the postwar period. Among the liveborn infants born during the war, 1373 (7.5%) had birth weight of <2500 g, which is significantly more in comparison with 851 (3.6%) liveborn infants in this birth weight group born before and 1864 (2.8%) after the war. We found the number of examinations during pregnancy was 1.8 per pregnant woman in the war period, which was low in comparison with the number of examinations before (4.6 per pregnant woman) and after (7.1 per pregnant woman) the war ( for both). Prewar perinatal mortality LBW infants of 6.2 per 1000 live births increased to 10.8 per 1000 live births during the war (), but after the war, perinatal mortality LBW infants (5.2‰) and early neonatal mortality (2.4‰) decreased.Conclusions. We found statistically significant association between low-birth-weight and maternal sociodemographic status in Tuzla Canton during 1992–1995 war in Bosnia and Herzegovina.

THE COMBINED EFFECT OF BIRTH WEIGHT AND LENGTH OF GESTATION ON NEONATAL MORTALITY AMONG SINGLE PREMATURE BIRTHS

PEDIATRICS ◽  
1955 ◽  
Vol 15 (6) ◽  
pp. 698-704
Author(s):  
Edward R. Schlesinger ◽  
Norman C. Allaway
Keyword(s):  
New York ◽  
Birth Weight ◽  
Neonatal Period ◽  
New York State ◽  
Combined Effect ◽  
Characteristic Pattern ◽  
Weight Group ◽  
York State ◽  
Birth Weight Group ◽  
Length Of Gestation

The combined effect of birth weight and length of gestation on mortality during the neonatal period was studied, using information obtained from birth and death certificates filed with the New York State Department of Health for births occurring during 1949, 1950, and 1951 in New York State, exclusive of New York City. The study covered 436,254 single live births over 20 weeks gestation for which data on both birth weight and length of gestation were available. Case fatality rates were determined by birth weight and gestation groups for the entire neonatal period and for 3 age intervals during the neonatal period. For the neonatal period as a whole a characteristic pattern is observed. Within each birth weight group 2500 gm. or less, longer gestation increases the chance of survival; within each gestation group 36 weeks or less, a higher birth weight has a similar effect. A typical example is the range in fatality rates for infants weighing 1001 to 1500 grams at birth. Within this birth weight group, the fatality rate ranges from 40 per cent in the gestation group of 36 weeks or over to 75 per cent in the 24 to 27 weeks gestation group. When fatality rates are computed for 3 successive age periods within the neonatal period, the combined effect of birth weight and gestation produces a characteristic pattern of fatality which is found to be most clearly defined during the first day after birth. However, a similar pattern of fatality is found to exist as well in the age periods from 1 through 6 days and for the remainder of the neonatal period.

scholarly journals Neonatal Birthmarks at the 4 Central Hospitals in Vientiane Capital, Lao PDR

2021 ◽  
Vol 8 ◽  
pp. 2333794X2199090
Author(s):  
Vilounna Sanaphay ◽  
Sourideth Sengchanh ◽  
Alongkone Phengsavanh ◽  
Anousavanh Sanaphay ◽  
Leelawadee Techasatian
Keyword(s):  
Sebaceous Gland ◽  
Neonatal Period ◽  
Lao Pdr ◽  
Skin Lesions ◽  
Medical Advice ◽  
Point Of View ◽  
Parental Anxiety ◽  
Skin Disorders ◽  
Clinical Point ◽  
Therapeutic Procedures

Newborn skin disorders are quite common and happen to occur during the neonatal period. Most of the birthmarks are transient; however, worried parents often seek medical advice from their child’s physician regarding skin lesions. Thus, it is important to differentiate the skin lesions from pathologic ones to avoid unnecessary diagnostic or therapeutic procedures. This is the first published study in Lao neonates that carried out the data from 4 central hospitals in Vientiane Capital, Lao PDR from September 2019 to February 2020. Among 500 neonates, Sebaceous gland hyperplasia (53%), Mongolian patches (46.6%), and Erythema toxicum neonatorum (30%) were the 3 most common cutaneous conditions found in the Lao newborns. From a clinical point of view, these findings are often a source of parental anxiety and medical concern for inexperienced clinicians.

Pericardial Effusion as a Complication of PICC Line Insertion

2021 ◽  
pp. 097321792110076
Author(s):  
Abdah Hrfi ◽  
Mohammed H.A. Mohammed ◽  
Omar Tamimi
Keyword(s):  
Birth Weight ◽  
Pericardial Effusion ◽  
Metabolic Diseases ◽  
Neonatal Period ◽  
Peripherally Inserted Central Catheter ◽  
Central Catheter ◽  
Preterm Baby ◽  
Line Insertion ◽  
Uncommon Condition ◽  
Picc Line

Cardiac tamponade as a result of pericardial effusion (PE) is a serious uncommon condition in the neonatal period. PE in such cases could be associated with hydrops fetalis, neonatal sepsis, metabolic diseases, or as a complication of percutaneous indwelling central catheter. 1 We are reporting a preterm baby, with low birth weight who developed large PE as a complication of total parenteral nutrition via a peripherally inserted central catheter, managed successfully with pericardiocentesis.

scholarly journals Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis

2021 ◽  
Vol 97 (2) ◽  
pp. 104-111
Author(s):  
Lisa M Vallely ◽  
Dianne Egli-Gany ◽  
Handan Wand ◽  
William S Pomat ◽  
Caroline S E Homer ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Perinatal Mortality ◽  
Low Income ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Middle Income ◽  
Middle Income Countries ◽  
Adverse Pregnancy

Objective To examine associations between Neisseria gonorrhoeae (NG) infection during pregnancy and the risk of preterm birth, spontaneous abortion, premature rupture of membranes, perinatal mortality, low birth weight and ophthalmia neonatorum. Data sources We searched Medline, EMBASE, the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature for studies published between 1948 and 14 January 2020. Methods Studies were included if they reported testing for NG during pregnancy and compared pregnancy, perinatal and/or neonatal outcomes between women with and without NG. Two reviewers independently assessed papers for inclusion and extracted data. Risk of bias was assessed using established checklists for each study design. Summary ORs with 95% CIs were generated using random effects models for both crude and, where available, adjusted associations. Results We identified 2593 records and included 30 in meta-analyses. Women with NG were more likely to experience preterm birth (OR 1.55, 95% CI 1.21 to 1.99, n=18 studies); premature rupture of membranes (OR 1.41, 95% CI 1.02 to 1.92, n=9); perinatal mortality (OR 2.16, 95% CI 1.35 to 3.46, n=9); low birth weight (OR 1.66, 95% CI 1.12 to 2.48, n=8) and ophthalmia neonatorum (OR 4.21, 95% CI 1.36 to 13.04, n=6). Summary adjusted ORs were, for preterm birth 1.90 (95% CI 1.14 to 3.19, n=5) and for low birth weight 1.48 (95% CI 0.79 to 2.77, n=4). In studies with a multivariable analysis, age was the variable most commonly adjusted for. NG was more strongly associated with preterm birth in low-income and middle-income countries (OR 2.21, 95% CI 1.40 to 3.48, n=7) than in high-income countries (OR 1.38, 95% CI 1.04 to 1.83, n=11). Conclusions NG is associated with a number of adverse pregnancy and newborn outcomes. Further research should be done to determine the role of NG in different perinatal mortality outcomes because interventions that reduce mortality will have the greatest impact on reducing the burden of disease in low-income and middle-income countries. PROSPERO registration number CRD42016050962.

scholarly journals The effects of intrauterine undernutrition on pancreas ghrelin and insulin expression in neonate rats

2007 ◽  
Vol 194 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Xiumin Wang ◽  
Li Liang ◽  
Lizhong Du
Keyword(s):  
Birth Weight ◽  
Plasma Insulin ◽  
Serum Insulin ◽  
Cell Distribution ◽  
Weight Group ◽  
Pregnant Rats ◽  
Normal Birth ◽  
Birth Weight Group ◽  
Total Ghrelin ◽  
Intrauterine Malnutrition

Ghrelin has a correlation with insulin secretion, β-cell development, and diabetes in crucial development period. The aim of this study was to compare the changes in plasma ghrelin, insulin, and glucose concentrations, and variation of ghrelin expression in the pancreas in response to intrauterine malnutrition in newborn rats. Pregnant rats at day 2 were randomly divided into two groups: nourished (fed ad libitum; NR) and undernourished rats (UR). The offspring of NR were defined as normal-birth-weight group (NBW, n = 79) and those of UR were defined as low-birth-weight group (LBW, n = 74). Plasma glucose, ghrelin, and serum insulin of both dams and their pups were analyzed at the first day after birth. The entire pancreas was collected for determination of ghrelin and insulin mRNAs, and quantification of pancreas ghrelin and insulin. Immunohistochemical double staining and confocal microscopy were performed on rat pancreas. Birth weight was 5.81 ± 0.64 and 4.76 ± 0.23 g in NBW group and LBW group respectively. Fasting plasma ghrelin concentrations in UR group (1382 (1287–1513) pg/ml) were higher than that of NR group (1072 (974–1205) pg/ml). Plasma ghrelin concentrations in the LBW group (2176 (2031–2384) pg/ml) were significantly lower than that of the NBW group (2493 (2311–2675) pg/ml). Undernutrition caused a decrease in plasma insulin concentrations in both UR dams and LBW pups (P < 0.001). Ghrelin mRNA and total ghrelin of pancreas were significantly affected by intrauterine nutrition state. Pancreas insulin concentrations were significantly affected by intrauterine nutrition (P = 0.007). The majority of ghrelin-producing cells were present at the periphery of islets in the NBW group. Ghrelin was colocalized with insulin in ß-cells in LBW group. The percentage of ghrelin-positive cells in the islets of LBW group was significantly higher than that of the NBW group (P < 0.01). Intrauterine undernutrition may affect the birth weight, plasma insulin and ghrelin levels, islet ghrelin expression, and ghrelin cell distribution. It will be interesting to investigate intrauterine nutrition which is involved in islet ghrelin expression and ghrelin cell distribution.

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