PITUITARY HORMONES IN WOMEN WITH CHRONIC RENAL FAILURE: THE EFFECT OF CHRONIC INTERMITTENT HAEMO-AND PERITONEAL DIALYSIS

1975 ◽  
Vol 80 (2) ◽  
pp. 237-246 ◽  
Author(s):  
K. Ølgaard ◽  
C. Hagen ◽  
A. S. McNeilly
Keyword(s):  
Growth Hormone ◽  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Significant Influence ◽  
Follicle Stimulating Hormone ◽  
Pituitary Hormones ◽  
Plasma Prolactin ◽  
Significant Difference ◽  
Before And After

ABSTRACT Measurements of plasma prolactin (hPr), growth hormone (HGH), thyrotrophin (TSH), luteinizing (LH) – and follicle stimulating hormone (FSH) were performed in 20 women with chronic renal failure on regular dialysis. There was no significant difference in any of the hormone levels before and after the dialysis and no significant influence of the type of dialysis (haemodialysis and peritoneal dialysis) or the time of dialysis. Higher levels of plasma prolactin was found in the women on peritoneal dialysis than in the haemodialyzed women presumably due to the medical treatment. In the peritoneally dialyzed group four women had irregular menstruations and normal gonadotrophic levels, but elevated hPr and it is suggested that this finding is similar to that seen in the amenorrhoeagalactorrhoea syndrome, where hPr presumably in some way have anti-gonadotrophic actions at the gonadal level.

Contribution of dialysis to endogenous oxalate production in patients with chronic renal failure

1994 ◽  
Vol 40 (8) ◽  
pp. 1544-1548 ◽  
Author(s):  
N C France ◽  
P T Holland ◽  
M R Wallace
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Isotope Dilution Mass Spectrometry ◽  
Product Inhibition ◽  
Maintenance Hemodialysis ◽  
Production Rates ◽  
Stable Isotope Dilution ◽  
Before And After ◽  
Buffering Agent

Abstract We tested the possibility that the buffering agents in dialysis bath fluid might contribute to increased endogenous oxalate production in dialyzed patients. Using stable isotope dilution mass spectrometry, we obtained oxalate production rates and pool sizes directly for 10 patients in chronic renal failure, 5 of whom were undergoing continuous ambulatory peritoneal dialysis (lactate-buffered fluid). All peritoneal dialysis patients had either increased oxalate production rates or expanded oxalate pools when compared with undialyzed patients in renal failure. From a further four patients receiving maintenance hemodialysis we took blood samples immediately before and after three consecutive dialysis sessions in which the bath-fluid buffering agent (bicarbonate or acetate) was alternated; we analyzed these samples for oxalate and key precursors by capillary gas chromatography. Plasma glycine and serine concentrations remained within the physiological range. Glycolate and oxalate concentrations decreased, but the oxalate remained above normal after dialysis. All changes were independent of the bath-fluid buffering agent. We suggest that dialysis might stimulate the formation of oxalate by removing product inhibition of a late catabolic step.

scholarly journals Etiology and outcome of peritoneal dialysis in 100 patients with chronic renal failure in Al-Ramadi Teaching

2020 ◽  
Vol 7 (2) ◽  
pp. 41-48
Author(s):  
Haitham N. AL-Koubaisy
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Teaching Hospital ◽  
Obstructive Uropathy ◽  
The Body ◽  
Common Disease ◽  
Human Beings ◽  
Significant Difference ◽  
Common Causes

Chronic renal failure is fatal disease because it leads to failure of excretory ,metabolic and endocrine functions of the kidneys which lead to disturb all physiological functions of the body some of these derangements is fatal to human beings to save human these body disturbances by chronic renal failure is treated by renal transplant and dialysis in different ways including peritoneal dialysis (PD.). Chronic renal failure is a common disease in patients attending Ramadi teaching hospital whom treated by peritoneal dialysis (PD) with variable results . So this study is introduced to detect the health status for managing chronic renal failure treated by peritoneal dialysis. All patients were 100 patients (53 male and 47 female) with CRF who admitted to the medical word in Al-Ramadi teaching hospital during a period from November 2008 till July 2009. Thorough history, examination and investigations were done for them including: hemoglobin, ESR ,blood urea, serum creatinine, ECG and abdominal U/S then PD was done for them according to their indications. The study showed that male was 53% with the age between 13 and 87 years while the female was 47% with the age between 12 and 91 years. Diabetes mellitus (DM) and hypertension (HT) were the most common cause of CRF. The outcome was: 30%complete improvement, 21% partial improvement, 26% less responsive and 23% died. In the last months of my study there was significant improvement. Inconclusion; DM and HT were the most common causes of CRF respectively; however obstructive uropathy had a notable ratio. There was no significant difference regarding sex. The outcome of PD was poor early in my study with significant improvements later.

PROLACTIN AND THE PITUITARY-GONADAL AXIS IN MALE URAEMIC PATIENTS ON REGULAR DIALYSIS

1976 ◽  
Vol 82 (1) ◽  
pp. 29-38 ◽  
Author(s):  
C. Hagen ◽  
K. Ølgaard ◽  
A. S. McNeilly ◽  
R. Fisher
Keyword(s):  
Growth Hormone ◽  
Follicle Stimulating Hormone ◽  
Plasma Concentrations ◽  
Sex Hormone Binding Globulin ◽  
Elevated Plasma ◽  
Hormone Binding ◽  
Hormone Levels ◽  
Significant Difference ◽  
Before And After ◽  
Male Patients

ABSTRACT In 21 consecutive adult male patients with chronic renal failure on regular haemo- or peritoneal dialysis, the plasma levels of prolactin (hPr), growth hormone (HGH), thyrotrophin (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T) and sex hormone binding globulin (SHBG) were measured. Elevated levels of hPr were found in 16 of the patients and could not only be explained by the medicamentation. All the patients studied showed an inverse ratio of LH to FSH with higher levels of FSH than LH and 15 of the 21 patients had elevated plasma concentrations of FSH, while only 4 had elevated LH. No significant difference in any of the hormone levels could be demonstrated before and after dialysis, and no significant correlation between the hormone levels and the time of dialysis, the type of dialysis or the age of the patient was found. However, 8 of the 21 patients showed higher levels of HGH before than after dialysis. Impotency was found in 11 of the patients, but was not related to abnormal levels of hPr, LH, FSH, T or SHBG.

Abnormal Fibrin Stabilization in Renal Failure

1969 ◽  
Vol 22 (02) ◽  
pp. 216-222 ◽  
Author(s):  
M. S Losowsky ◽  
W. D Walls
Keyword(s):  
Renal Failure ◽  
Wound Healing ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Plasma Fibrinogen ◽  
Contributory Factor ◽  
Quantitative Technique ◽  
Significant Difference

SummaryPlasma F.S.F. activity was measured by a quantitative technique in 41 patients with renal failure. It was subnormal in 35, being undemonstrable in 32.There was no significant difference in activity between patients with acute and patients with chronic renal failure, and co-existing jaundice had no significant effect on plasma F. S. F. activity.Plasma fibrinogen concentrations were frequently increased. Patients with the highest levels of plasma fibrinogen tended to retain demonstrable F.S.F. activity.Plasma F.S.F. activity was not related to the height of the blood urea.Haemodialysis and peritoneal dialysis had no significant effect on plasma F.S.F. activity.Plasma F.S.F. activity returned to normal following recovery of acute renal failure.Diminished plasma F.S.F. activity did not appear to be responsible for abnormal haemorrhage although it may act as a contributory factor.It is suggested that impaired fibrin stabilization might be responsible for abnormal wound healing in uraemia.

β-Thromboglobulin in Patients with Chronic Renal Failure: Effect of Hemodialysis

1979 ◽  
Author(s):  
D. Green ◽  
S. Santhanam ◽  
F.A. Krumlovsky ◽  
F. del Greco
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Normal Subjects ◽  
Sensitive Indicator ◽  
Severe Thrombocytopenia ◽  
Average Increase ◽  
Mean Values ◽  
Platelet Counts ◽  
Before And After

β-Thromboglobulin (β-TG), a protein located in the α-granules of platelets, is released into the plasma when platelets are disrupted. Since plasma β-TG is cleared by the kidney, we measured β-TG levels in normal subjects and and in patients with chronicrenal failure, using a radioimmunoassay kit (Amersham Corp.). In 24 controls, mean values were 27 ± 12 (S.D.) ng ml-l and in 24 patients, 123 ± 41 ng ml-l , P <0.001. Because hemodialysis may induce platelet damage, we examined β-TG levels in patients before and after dialysis. Although platelet counts were unchanged, plasma β-TG levels rose in all but 2 patients, with an average increase of 30 ng ml-l. That the increase in β-TG was due to platelet disruption was confirmed by (1) no change in β-TG in 3 patients having peritoneal dialysis, and (2) studies of a patient with radiation nephritis and severe thrombocytopenia (18,000 per cu mm) secondary to chemotherapy. β-TG was 12 nR ml-l and did not increase after hemodialysis. We conclude that plasma β-TG is significantly elevated in patients with chronic renal failure, and that measurement of this protein provides a sensitive indicator of platelet disruption by hemodialysis.

scholarly journals The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values

2004 ◽  
Vol 23 (2) ◽  
pp. 175-178
Author(s):  
Emina Colak ◽  
Sanja Stankovic ◽  
Nada Majkic-Singh ◽  
Milan Radovic
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Underlying Disease ◽  
Tubular Secretion ◽  
Acid Base Balance ◽  
Acid Base ◽  
Significant Difference ◽  
Before And After ◽  
Base Balance

Due to reduced scope of renal function in chronic renal failure (CRF) it is not rare that it comes to marked metabolic acidosis and pathologic catabolism associated with hypoxia. The cause of metabolic acidosis is deminished tubular secretion of ammonia, due to reduced synthesis, stipulated by lower number of renal canaliculi. Acid-base balance was analyzed in 74 patients suffering from CRF who were on haemodialysis program. Heparinised blood was taken from these patients before and after haemodialysis in which the following parameters were measured: pH, pCO2, pO2, HCO-3 ?, TCO2. The aim of this study was the monitoring of patients' acid-base status before and after haemodilalysis in order to evaluate the degree of stabilization of acid-base balance after haemodilalysis and also to define the correlation between the etiology of CRF and the degree of acid-base balance disorder. In relation to underlying disease resulting in CRF, the patients were divided into five groups: I-tubular interstitial nephrosis (TIN), II-polycystic kidney disease (ADPKD), III-glomerulonephritis (GN), IVhypertension and nephroangio-sclerosis (HTA-Nascl) and V-consisting of patients whose underlying disease was not diagnosed (ERSD). The obtained values of pH, HCO2 and TCO2 after haemodialysis (pH = 7.428 ? 0.06; HCO-3 ?= 25.4 ? 3.44 mmol/L; TCO2 = 26.57 ? 3.56 mmol/L), were significantly increased (p<0.001), in relation to values before haemodialysis (pH = 7.350 ? 0.05; HCO-3 ?= 20.88 ? 2.92 mmol/L; TCO2 = 22.03 ? 3.00 mmol/L). There was no statistically significant difference in values of measured parameters (p>0.05) in relation to underlying disease either before or after haemodialysis both in males and females.

Etiology and outcome of peritoneal dialysis in 100 patients with chronic renal failure in Al-Ramadi Teaching

2020 ◽  
Vol 7 (2) ◽  
pp. 41-48
Author(s):  
Haitham N. AL-Koubaisy ◽  
Khalid A. AL-Rawi ◽  
Bahget Sweedan
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Teaching Hospital ◽  
Obstructive Uropathy ◽  
The Body ◽  
Common Disease ◽  
Human Beings ◽  
Significant Difference ◽  
Common Causes

Chronic renal failure is fatal disease because it leads to failure of excretory ,metabolic and endocrine functions of the kidneys which lead to disturb all physiological functions of the body some of these derangements is fatal to human beings to save human these body disturbances by chronic renal failure is treated by renal transplant and dialysis in different ways including peritoneal dialysis (PD.). Chronic renal failure is a common disease in patients attending Ramadi teaching hospital whom treated by peritoneal dialysis (PD) with variable results . So this study is introduced to detect the health status for managing chronic renal failure treated by peritoneal dialysis. All patients were 100 patients (53 male and 47 female) with CRF who admitted to the medical word in Al-Ramadi teaching hospital during a period from November 2008 till July 2009. Thorough history, examination and investigations were done for them including: hemoglobin, ESR ,blood urea, serum creatinine, ECG and abdominal U/S then PD was done for them according to their indications. The study showed that male was 53% with the age between 13 and 87 years while the female was 47% with the age between 12 and 91 years. Diabetes mellitus (DM) and hypertension (HT) were the most common cause of CRF. The outcome was: 30%complete improvement, 21% partial improvement, 26% less responsive and 23% died. In the last months of my study there was significant improvement. Inconclusion; DM and HT were the most common causes of CRF respectively; however obstructive uropathy had a notable ratio. There was no significant difference regarding sex. The outcome of PD was poor early in my study with significant improvements later.

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