PROLACTIN AND THE PITUITARY-GONADAL AXIS IN MALE URAEMIC PATIENTS ON REGULAR DIALYSIS

1976 ◽  
Vol 82 (1) ◽  
pp. 29-38 ◽  
Author(s):  
C. Hagen ◽  
K. Ølgaard ◽  
A. S. McNeilly ◽  
R. Fisher
Keyword(s):  
Growth Hormone ◽  
Follicle Stimulating Hormone ◽  
Plasma Concentrations ◽  
Sex Hormone Binding Globulin ◽  
Elevated Plasma ◽  
Hormone Binding ◽  
Hormone Levels ◽  
Significant Difference ◽  
Before And After ◽  
Male Patients

ABSTRACT In 21 consecutive adult male patients with chronic renal failure on regular haemo- or peritoneal dialysis, the plasma levels of prolactin (hPr), growth hormone (HGH), thyrotrophin (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T) and sex hormone binding globulin (SHBG) were measured. Elevated levels of hPr were found in 16 of the patients and could not only be explained by the medicamentation. All the patients studied showed an inverse ratio of LH to FSH with higher levels of FSH than LH and 15 of the 21 patients had elevated plasma concentrations of FSH, while only 4 had elevated LH. No significant difference in any of the hormone levels could be demonstrated before and after dialysis, and no significant correlation between the hormone levels and the time of dialysis, the type of dialysis or the age of the patient was found. However, 8 of the 21 patients showed higher levels of HGH before than after dialysis. Impotency was found in 11 of the patients, but was not related to abnormal levels of hPr, LH, FSH, T or SHBG.

The Relationship between Sex Steroids and Sex-Hormone-Binding Globulin in Plasma in Physiological and Pathological Conditions

1985 ◽  
Vol 22 (5) ◽  
pp. 489-497 ◽  
Author(s):  
Sean K Cunningham ◽  
Therese Loughlin ◽  
Marie Culliton ◽  
T Joseph McKenna
Keyword(s):  
Plasma Concentrations ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Plasma Testosterone ◽  
Hormone Binding ◽  
Marked Decline ◽  
Male Patients ◽  
Opposing Effects

Physiological and many pathological changes in plasma sex-hormone-binding globulin (SHBG) levels have been attributed to the opposing effects of androgens which lower, and oestrogens which elevate, levels. We examined four clinical situations in which changes in SHBG levels may not be explained by sex steroid alterations. (1) Dexamethasone caused an increase in SHBG levels in hyperandrogenaemic hirsute women whether or not androgens were suppressed. (2) In male patients with untreated isolated gonadotrophin deficiency there was a highly significant correlation between SHBG levels and age, but there was no relationship between the levels of SHBG and those of plasma testosterone, androstenedione or DHEAS. (3) Two 46-XY siblings, phenotypic female subjects with complete androgen insensitivity, demonstrated a marked decline in SHBG levels between the ages of 9–13 and 12–16 years. (4) SHBG was suppressed in obese oligomenorrhoeic women while plasma concentrations of testosterone, androstenedione and oestradiol were normal and that of oestrone was elevated; however, the testosterone: SHBG ratio, an index of free testosterone, was elevated. These observations indicate that the decline in SHBG levels which normally occurs in men during the second decade of life is independent of androgen activity and is under the influence of as yet unidentified factors. Glucocorticoids in small doses increase SHBG levels independently of sex steroid alterations while elevated free testosterone concentration may contribute to suppression of SHBG in obesity.

PITUITARY HORMONES IN WOMEN WITH CHRONIC RENAL FAILURE: THE EFFECT OF CHRONIC INTERMITTENT HAEMO-AND PERITONEAL DIALYSIS

1975 ◽  
Vol 80 (2) ◽  
pp. 237-246 ◽  
Author(s):  
K. Ølgaard ◽  
C. Hagen ◽  
A. S. McNeilly
Keyword(s):  
Growth Hormone ◽  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Significant Influence ◽  
Follicle Stimulating Hormone ◽  
Pituitary Hormones ◽  
Plasma Prolactin ◽  
Significant Difference ◽  
Before And After

ABSTRACT Measurements of plasma prolactin (hPr), growth hormone (HGH), thyrotrophin (TSH), luteinizing (LH) – and follicle stimulating hormone (FSH) were performed in 20 women with chronic renal failure on regular dialysis. There was no significant difference in any of the hormone levels before and after the dialysis and no significant influence of the type of dialysis (haemodialysis and peritoneal dialysis) or the time of dialysis. Higher levels of plasma prolactin was found in the women on peritoneal dialysis than in the haemodialyzed women presumably due to the medical treatment. In the peritoneally dialyzed group four women had irregular menstruations and normal gonadotrophic levels, but elevated hPr and it is suggested that this finding is similar to that seen in the amenorrhoeagalactorrhoea syndrome, where hPr presumably in some way have anti-gonadotrophic actions at the gonadal level.

scholarly journals Circulating Hormone Levels in Hatchlings of Green Turtle, Chelonia mydas, from Ras Al-Hadd Reserve, Oman

2005 ◽  
Vol 10 ◽  
pp. 43
Author(s):  
A. Y. A. AlKindi
Keyword(s):  
Green Turtle ◽  
Follicle Stimulating Hormone ◽  
Plasma Concentrations ◽  
Chelonia Mydas ◽  
Weak Correlation ◽  
Chemiluminescence Immunoassay ◽  
Hormone Levels ◽  
Significant Difference ◽  
Plasma Estradiol

Post-hatching levels of plasma estradiol (E2), Progesterone (Pro), testosterone (T), Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH) and thyroxine (T4) were monitored in hatchlings of Green Turtle, Chelonia mydas immediately after emergence. Eggs were collected at random from 5 nests. The eggs were placed in incubators 16 hr after oviposition set at 26-27oC for male producing hatchlings and at 30-31oC for female producing hatchlings. Blood was collected after sacrifice. Chemiluminescence immunoassay was used for determination of plasma hormone levels, using Beckman Coulter Access-2-immunoassay and reagents (Beckman Coulter, Inc.). Sex was determined from histological examination of gonads. In males, plasma T levels were positively correlated with temperature (rho = 0.67, P<0.001). However, plasma E2 levels were negatively correlated but not strongly with temperature (rho = -0.396, P<0.05) and there was a weak correlation between plasma LH levels and temperatures (rho = 0.38, P<0.05). Also in the males, there was no correlation between temperature and either plasma Pro or T4 levels.  In females, there was no correlation between temperature and any of the hormones. In addition, there was no significant difference in plasma concentrations of T, Pro, LH or T4 between sexes. However, plasma E2 concentrationwas significantly higher in males (P<0.05). FSH was undetectable in plasma from both sexes. The significance of these findings will be discussed.  

Changes In Prothrombin And Activated Partial Thromboplastin Time During Replacement Therapy With Human Recombinant Growth Hormone In Growth Hormone Deficient Adults

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S102-S103
Author(s):  
Y S Kamel
Keyword(s):  
Growth Hormone ◽  
Replacement Therapy ◽  
Healthy Subjects ◽  
Recombinant Growth Hormone ◽  
Gh Replacement ◽  
Coagulation Tests ◽  
Before And After ◽  
Human Recombinant Growth Hormone ◽  
Male Patients ◽  
One Year

Abstract Introduction/Objective The aim of this study was to investigate the effects of GH administration on basic coagulation parameters: PT, aPTT and fibrinogen concentrations in adult GHD patients before and during one year of GH replacement. Methods Twenty-one adult patients with severe GHD (mean age +/- SE: 38.6 +/- 2.8 years) were included in this hospital based, prospective, interventional study. All patients were treated with rhGH for 12 months (GH dose: 0.4 mg/day for male and 0.6 mg/day for female patients). IGF-1 concentrations were determined using RIA-INEP kits. Basic coagulation tests, i.e. aPTT and fibrinogen concentrations, were measured before and after 3, 6 and 12 months of treatment with rhGH. Control values were obtained from fourteen “healthy” subjects matched by age, sex and body mass index (BMI). Results At baseline, we observed no significant differences in PT, aPTT and fibrinogen values between GHD and healthy subjects. IGF-1 concentrations increased significantly within 3 months of GH therapy (8.2 +/- 1.5 vs. 24.2 +/- 2.9 nmol/l, p &lt;0.05) and remained stable thereafter. A significant increase in PT values, which was more pronounced in female subjects, was noted after 6 and 12 months of treatment with GH. aPTT values increased significantly after 12 months of treatment only in male patients (28.8 +/- 4.6 vs. 39.7 +/- 2.1 s.; p &lt;0.05). No significant changes in fibrinogen concentrations were found during the study. Conclusion Twelve months of GH replacement therapy led to a significant increase in PT and aPTT values in adult GHD patients, while fibrinogen concentrations did not change. Changes in PT were more pronounced in female GHD patients, while an increase in aPTT values was observed only in male patients with GHD. The clinical significance of these changes needs further evaluation.

ENDOCRINE CHANGES IN MALE SEXUAL DEVIANTS AFTER TREATMENT WITH ANTI-ANDROGENS, OESTROGENS OR TRANQUILLIZERS

1975 ◽  
Vol 67 (2) ◽  
pp. 179-188 ◽  
Author(s):  
M. A. F. MURRAY ◽  
J. H. J. BANCROFT ◽  
D. C. ANDERSON ◽  
T. G. TENNENT ◽  
P. J. CARR
Keyword(s):  
Sexual Offenders ◽  
Cyproterone Acetate ◽  
Follicle Stimulating Hormone ◽  
Sex Hormone Binding Globulin ◽  
Plasma Testosterone ◽  
Total Plasma ◽  
Hormone Binding ◽  
Endocrine Effects ◽  
Threefold Increase ◽  
Special Hospital

SUMMARY The endocrine effects of drugs on two groups of 12 male sexual offenders in a special hospital were studied. In the first study benperidol, chlorpromazine and placebo were compared and in the second ethynyl oestradiol and cyproterone acetate were compared with no treatment. In the first study there was no difference between the three drugs in their effects on plasma testosterone or luteinizing hormone (LH). In the second study cyproterone acetate produced a reduction in plasma testosterone, LH and follicle-stimulating hormone (FSH). Ethynyl oestradiol produced a rise in plasma testosterone and LH, and no change in FSH. Neither drug changed total plasma oestrogen levels. The unexpected effects of ethynyl oestradiol were attributed to an increase in sex hormone-binding globulin (SHBG) leading to a rise in bound, inactive testosterone. Direct measurement showed a two- to threefold increase in SHBG with ethynyl oestradiol treatment and no change in SHBG with cyproterone acetate treatment. In spite of these contrasting endocrine effects, ethynyl oestradiol, cyproterone acetate and benperidol produced similar behavioural changes.

scholarly journals Flavonoid Intake and Plasma Sex Steroid Hormones, Prolactin, and Sex Hormone-Binding Globulin in Premenopausal Women

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2669
Author(s):  
You Wu ◽  
Susan E. Hankinson ◽  
Stephanie A. Smith-Warner ◽  
Molin Wang ◽  
A. Heather Eliassen
Keyword(s):  
Linear Models ◽  
Geometric Mean ◽  
Plasma Concentrations ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Hormone Binding ◽  
Chemical Structures ◽  
Flavonoid Intake

Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires collected in 1995 and 1999. We used generalized linear models to calculate geometric mean hormone concentrations across categories of the intake of flavonoids and the subclasses. Results: Total flavonoid intake generally was not associated with the hormones of interest. The only significant association was with DHEAS (p-trend = 0.02), which was 11.1% (95% confidence interval (CI): −18.6%, −3.0%) lower comparing the highest vs. lowest quartile of flavonoid intake. In subclass analyses, the highest (vs. lowest) quartile of flavan-3-ol intake was associated with significantly lower DHEAS concentrations (−11.3% with 95% CI: −18.3%, −3.7%, p-trend = 0.01), and anthocyanin intake was associated with a significant inverse trend for DHEA (−18.0% with 95% CI: −27.9%, −6.7%, p-trend = 0.003). Conclusion: Flavonoid intake in this population had limited impact on most plasma sex hormones in premenopausal women. Anthocyanins and flavan-3-ols were associated with lower levels of DHEA and DHEAS.

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