DIFFERENT EFFECTS OF EXOGENOUS CYCLIC ADENOSINE MONOPHOSPHATE AND ITS DIBUTYRYL DERIVATIVE ON PLASMA GROWTH HORMONE, GLUCOSE, INSULIN AND CORTISOL

1976 ◽  
Vol 83 (1) ◽  
pp. 15-25
Author(s):  
M. Vanderschueren-Lodeweyckx ◽  
W. Proesmans ◽  
E. Eggermont ◽  
R. Eeckels
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Subjects ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
The Mean

ABSTRACT The effects of the infusion in four different dosages (0.001, 0.005, 0.02 and 0.2 mg/kg/min during 60 min) of cyclic 3′,5′-adenosine monophosphate and of its dibutyryl derivative on plasma growth hormone and on glucose, immunoreactive insulin and cortisol were studied in 38 normal subjects and in 10 patients with idiopathic hypopituitarism. In normal subjects cyclic 3′,5′-adenosine monophosphate provokes an increase in plasma growth hormone levels (only when a dosage of 0.2 mg/kg/min is used) without any changes in plasma glucose, insulin and cortisol. The maximal value of the means is observed 75 min after starting the infusion. Dibutyryl cyclic 3′,5′-adenosine monophosphate (0.2 and 0.02 mg/kg/min) provokes a dose-related rise in plasma growth hormone levels which is always preceded by hyperglycaemia and hyperinsulinaemia. The peak of the mean growth hormone levels occurs at 135 min after initiation of the infusion. In all but one hypopituitary patients the nucleotides do not promote growth hormone secretion. It is concluded that exogenous cyclic 3′,5′-adenosine monophosphate and its dibutyryl derivative may not be considered as analogous and that both compounds may contribute to study growth hormone release in normal subjects and in patients with growth abnormalities.

CHANGES IN PLASMA GROWTH HORMONE AND INSULIN OF THE HUMAN FOETUS FOLLOWING HYSTEROTOMY

1971 ◽  
Vol 66 (4) ◽  
pp. 577-586 ◽  
Author(s):  
R. C. Turner ◽  
B. Schneeloch ◽  
P. Paterson
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Plasma Insulin Concentration ◽  
Plasma Immunoreactive Insulin ◽  
The Mean ◽  
Serial Samples

ABSTRACT Plasma immunoreactive insulin and growth hormone of 20–24 weeks' gestation human foetuses were assayed in serial samples following delivery by hysterotomy. The mean umbilical cord plasma growth hormone concentration was 71 ng/ml (range 13–120 ng/ml) and the mean plasma insulin was 5 μU/ml (range 2–8 μU/ml). Following delivery the growth hormone levels increased, but there was no significant change in plasma insulin concentration. The hypothalamic-hypophyseal axis controlling growth hormone secretion appears to be developed by 20 weeks' gestation, and »stress« appears to be a provocative stimulus.

scholarly journals The dopaminergic regulation of plasma growth hormone secretion in normal subjects.

1986 ◽  
Vol 148 (2) ◽  
pp. 151-158 ◽  
Author(s):  
KUNIHIKO HANEW ◽  
SHUICHI SATO ◽  
ATSUSHI SASAKI ◽  
MEIGAN GOH ◽  
YASUYUKI SHIMIZU ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Plasma Growth Hormone ◽  
Dopaminergic Regulation

Growth hormone secretion in human acromegalic pituitary adenomas: Cyclic adenosine monophosphate and protein kinase C responses

Metabolism ◽  
1996 ◽  
Vol 45 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Tatsuo Ishizuka ◽  
Hiroyuki Morita ◽  
Tomoatsu Mune ◽  
Hisashi Daidoh ◽  
Junko Hanafusa ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Pituitary Adenomas ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Kinase C

Acetate: inhibitor of growth hormone hypersecretion in diabetic and non-diabetic uraemic subjects

1982 ◽  
Vol 99 (4) ◽  
pp. 551-558 ◽  
Author(s):  
Hans Ørskov ◽  
Aage Prange Hansen ◽  
Hans Erik Hansen ◽  
K. George M. M. Alberti ◽  
George A. Noy ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Normal Values ◽  
Hormone Secretion ◽  
Plasma Concentrations ◽  
Growth Hormone Secretion ◽  
Hormone Release ◽  
Plasma Growth Hormone ◽  
Blood Samples ◽  
Hormone Levels

Abstract. Five diabetic and 14 non-diabetic uraemic patients on long-term haemodialysis were studied during twenty-one 24 h periods including 5 to 7 h of haemodialysis against glucose-free acetate buffered dialysis fluid. Half-hourly blood samples were collected for hormonal and metabolite analysis. In addition, blood samples were analyzed in 40 experiments covering the haemodialysis and a pre-dialysis period. Before dialysis, plasma growth hormone levels were high and fluctuating, but almost always fell to low normal values within the first 2 h of haemodialysis. In the diabetic uraemic patients, the occasional severe hypoglycaemic episodes occurring during haemodialysis did not provoke growth hormone release, and hypoglycaemic reactions were not encountered. Intravenous acetate infusion studies resulted in plasma concentrations ranging from 1.3 to 2.7 mmol, i.e. about 60 per cent of the levels reached during haemodialysis and in suppression of growth hormone secretion. It is suggested that the fall in growth hormone levels and the lack of hypoglycaemic symptoms during haemodialysis is due to the use of acetate as a fuel in brain.

Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans

1992 ◽  
Vol 263 (1) ◽  
pp. E168-E172 ◽  
Author(s):  
P. J. Boyle ◽  
A. Avogaro ◽  
L. Smith ◽  
D. M. Bier ◽  
A. S. Pappu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Fatty Acid ◽  
Cholesterol Synthesis ◽  
Gh Deficiency ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Nonesterified Fatty Acid ◽  
Rate Limiting Step ◽  
Nocturnal Increase

To define the role that nocturnal increments in growth hormone (GH) play in maintaining lipolysis, glycerol turnover was measured in six patients with GH deficiency and six normal subjects during sleep. Glycerol production initially decreased in both groups but then increased to 1.44 +/- 0.20 mumol.kg-1.min-1 by 0800 h in normal subjects, whereas GH deficiency was associated with a continuous fall to 0.77 +/- 0.10 mumol.kg-1.min-1, P less than 0.02. Nonesterified fatty acid levels paralleled these changes. Six GH-deficient patients received basal GH replacement including a pulse during sleep, which resulted in normal fasting fatty acid levels (P less than 0.05, replaced vs. chronic deficiency). To assess a possible link between the normal nocturnal increase in plasma mevalonate (the product of the rate-limiting step in cholesterol synthesis) and sleep-associated GH release, 11 GH-deficient patients and 11 normal subjects were studied. Peak nocturnal and fasting mevalonate concentrations were not correlated with GH level. We conclude that nocturnal growth hormone secretion is essential for maintaining lipolysis but that it is not related to normal increments in mevalonate and, by inference, to cholesterol synthesis during sleep

Effect of L-Tryptophan on Apomorphine-Induced Growth Hormone Secretion in Normal Subjects

1980 ◽  
Vol 13 (06) ◽  
pp. 331-335 ◽  
Author(s):  
S. Lal ◽  
S. Young ◽  
P. Cervantes ◽  
H. Guyda
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects

Growth Hormone Secretion in Acid-Base Alterations at Rest and during Exercise

1976 ◽  
Vol 50 (4) ◽  
pp. 241-247 ◽  
Author(s):  
J. R. Sutton ◽  
N. L. Jones ◽  
C. J. Toews
Keyword(s):  
Growth Hormone ◽  
Lactic Acid ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cycle Ergometer ◽  
Ion Concentration ◽  
Plasma Growth Hormone ◽  
Double Blind ◽  
Hydrogen Ion Concentration ◽  
Ergometer Exercise

1. Seven healthy males were studied during cycle ergometer exercise at 33%, 66% and 90% of V̇o2 max. on three occasions when NH4Cl, NaHCO3 or CaCO3 (as a control substance) were administered in gelatin capsules double blind and in randomized order. Plasma growth hormone (HGH), lactic acid and hydrogen ion concentration ([H+])weremeasured at frequent intervals. 2. Ammonium chloride produced highest blood [H+] and NaHCO3 the lowest. These differences were maintained during exercise and in recovery. Plasma lactic acid concentrations were similar at rest. At 66%, 90% V̇o2 max. and recovery lactic acid was highest with NaHCO3 and lowest with NH4Cl. 3. Exercise stimulated HGH secretion in all studies and the elevation was proportional to the intensity of the exercise. NH4Cl caused a variable elevation of HGH at rest and 33% V̇o2 max. At 66% V̇o2 max., plasma HGH was significantly elevated to similar concentrations in all studies and, at 90% V̇o2 max., HGH was highest with NaHCO3. 4. An infusion of sodium l(+)-lactate producing plasma lactate concentrations of 3–5 mmol/l did not influence HGH secretion. 5. Exercise is a physiological stimulus to HGH secretion and the mechanism is independent of blood [H+] and lactate concentrations.

Increased hypothalamic somatostatin mRNA following dexamethasone administration in rats

1992 ◽  
Vol 127 (5) ◽  
pp. 416-419 ◽  
Author(s):  
Koji Nakagawa ◽  
Tatsuya Ishizuka ◽  
Chikara Shimizu ◽  
Yoshito Ito ◽  
Ichiji Wakabayashi
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Female Rats ◽  
Mrna Levels ◽  
Plasma Growth Hormone ◽  
Hormone Production ◽  
Blot Technique ◽  
Series Of Experiments

There is increasing evidence to suggest that supraphysiological doses of glucocorticoids suppress growth hormone secretion in vivo by augmenting somatostatin release from the hypothalamus; previously, we reported an increase in hypothalamic somatostatin content in dexamethasone-treated rats. To further examine whether the production of somatostatin really is augmented, hypothalamic somatostatin mRNA levels were determined by the Northern blot technique in female rats receiving 330 μg of dexamethasone daily for three days. In two series of experiments, hypothalamic somatostatin mRNA levels in dexamethasone-treated rats were significantly (p<0.05) increased to 133±19 (mean±sd)% and 153±38% of the controls. In the dexamethasone-treated rats, plasma growth hormone levels were markedly suppressed compared with those of the controls. These results further support the hypothesis that pharmacological doses of glucocorticoids increase the production and release of somatostatin from the hypothalamus and thus inhibit growth hormone secretion, overriding the direct stimulatory effect of glucocorticoids on growth hormone production at the pituitary level.

Effect of synthetic thyrotrophin-releasing hormone and its analogues on growth hormone secretion in the domestic fowl (Gallus Domesticus)

1981 ◽  
Vol 97 (4) ◽  
pp. 448-453 ◽  
Author(s):  
C. G. Scanes ◽  
S. Harvey ◽  
B. A. Morgan ◽  
M. Hayes
Keyword(s):  
Growth Hormone ◽  
Domestic Fowl ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Gallus Domesticus ◽  
Plasma Growth Hormone ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Trh Analogues

Abstract. Variations in plasma growth hormone (GH) concentrations following iv or sc administration of synthetic thyrotrophin-releasing hormone (TRH, Pyr-His-Pro-NH2) have been followed in immature and adult domestic fowl. TRH markedly stimulated GH secretion in newly hatched (1 and 2 day old) chicks and in 6-week-old cockerels but in adult male or female birds of two strains had very little effect, if any. Intravenous injection of 4 TRH analogues (Pyr-His-Mep-NH2, Pyr-Meh-Mep-NH2, Pyr-Meh-Mep-NH and Pyr-Meh-Pro-NH2) were also potent GH secretagogues in 6-week-old birds. The stimulatory effect of TRH or the TRH-analogues on GH secretion was not dose-related.

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