PITUITARY-THYROID FUNCTION IN SPIRONOLACTONE TREATED HYPERTENSIVE WOMEN

1979 ◽  
Vol 90 (3) ◽  
pp. 577-584 ◽  
Author(s):  
A. G. H. Smals ◽  
P. W. C. Kloppenborg ◽  
W. H. L. Hoefnagels ◽  
J. I. M. Drayer
Keyword(s):  
Thyroid Function ◽  
Bolus Injection ◽  
Serum Testosterone ◽  
High Dose ◽  
Enhancing Effect ◽  
Basal Serum ◽  
The Mean ◽  
17 Hydroxyprogesterone ◽  
Lh Rh ◽  
Serum Tsh

ABSTRACT Four weeks high dose spironolactone treatment (Aldactone® Searle, 100 mg q. i. d.) significantly enhanced the TSH (Δ max. 8.5 ± 4.1 vs. 4.6 ± 3.1 μU/ml, P < 0.05) and T3 (Δ max. 32±27 vs. 11 ± 16 ng/100 ml, P < 0.05) responses to an intravenous TRH/LH-RH bolus injection in 6 eumenorrhoeic euthyroid hypertensive women, without affecting basal serum TSH, T3 or T4 levels or the basal and stimulated LH, FSH and prolactin values (P > 0.10). The mean serum testosterone, 17-hydroxyprogesterone and oestradiol levels were also similar before and during therapy. Spironolactone, possibly by virtue of its antiandrogenic action, may exert its enhancing effect on pituitary-thyroid function by modulating the levels of receptors for TRH in the thyrotrophs or by altering the T3 receptor in the pituitary permitting a greater response to TRH.

SOME ASPECTS OF HYPOTHALAMIC-PITUITARY FUNCTION IN PATIENTS WITH ANOREXIA NERVOSA

1976 ◽  
Vol 81 (2) ◽  
pp. 252-262 ◽  
Author(s):  
P. Travaglini ◽  
P. Beck-Peccoz ◽  
C. Ferrari ◽  
B. Ambrosi ◽  
A. Paracchi ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Serum Testosterone ◽  
Normal Subjects ◽  
Control Group ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
Normal Increase ◽  
Lh Rh ◽  
Serum Tsh

ABSTRACT The secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotrophin (TSH) and prolactin (PRL, was studied in 17 women suffering from anorexia nervosa. The mean basal serum LH was reduced (8.4 ± 0.8 se mIU/ml; P < 0.001 vs normal controls), while LH increase after gonadotrophin-releasing hormone (LH-RH) appeared to be normal in 9 cases and impaired in 6 cases. The mean basal FSH did not significantly differ from normal subjects (3.9 ± 0.5 mIU/ml), while LH-RH administration elicited an exaggerated increase in 7 cases and a normal increase in 8 cases: the mean FSH response was significantly higher than in controls (P < 0.02). Plasma oestradiol-17β was reduced (20.4 ± 0.4 pg/ml; P < 0.001) while the serum testosterone levels were normal (0.73 ± 0.09 ng/ml). Clomiphene administration induced an increase in gonadotrophins in only 1 out of 7 patients. The mean serum TSH concentration was normal (2.3 ± 0.4 μU/ml), while serum thyroxine and triiodothyronine and free thyroxine index, though generally in the normal range, were significantly lower than values obtained in a control group (6.1 ± 0.4 μg/100 ml, P< 0.005; 102.3±7.7 ng/100 ml, P <0.005; 3.8±0.3, P < 0.05). Though the mean serum TSH increase after thyrotrophin-releasing hormone (TRH) was normal (12.0 ± 2.3 μU/ml), there were 4 impaired and 1 exaggerated increases, and 8 patients showed a delayed and frequently prolonged response. The increase in serum T3 after TRH appeared lower than in normal subjects (36.3 ± 1.8 ng/100 ml, P < 0.001). Serum PRL levels in basal conditions were higher than in the controls (19.4 ± 4.1 ng/ml, P < 0.001) while the increase in PRL after TRH was exaggerated in only 2 patients. The present data suggest that the primary failure in gonadotrophin secretion in anorexia nervosa occurs at hypothalamic level; moreover the data on TSH and PRL secretion also point to the existence of a hypothalamic disorder in this disease.

scholarly journals Clinical Finding and Thyroid Function in Women with Struma Ovarii

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Ali Hosseini ◽  
Aida Moeini
Keyword(s):  
Thyroid Function ◽  
Final Analysis ◽  
Thyroid Function Test ◽  
Struma Ovarii ◽  
Presenting Symptoms ◽  
Function Test ◽  
Average Patient ◽  
The Mean ◽  
Serum Tsh ◽  
Hormonal Levels

Background. Struma ovarii (SO) is a variant of dermoid tumors which completely or mainly composed of thyroid tissues. Objective. We report our experience in the diagnosis and thyroid function of patients with SO in our hospital and also review the management and treatment option of this tumor. Materials and Methods. Between 2000 and 2012, 15 consecutive females with SO who were presented to our hospital were fully assessed. All women had histologically confirmed struma ovarii. The medical records of all patients including presenting symptoms, CT scan finding, and hormonal levels were collected for final analysis. Results. Average patient age was 36.6 years (ranging from 21 to 69). The mean ± SDs of serum TSH, T4, and T3 were  mUI/mL,  ng/dL, and  ng/dL, respectively. The value of TSH was lower than normal value in 26.7%. Also, antithyroglobulin and anti-TPO were positive in 2 and one cases, respectively. Conclusion. Based on our data, it is more likely to see a disturbance in serum values of thyroid function test in women with SO.

Testicular responsiveness to hCG during infancy measured by salivary testosterone

1990 ◽  
Vol 123 (6) ◽  
pp. 633-636 ◽  
Author(s):  
Leo Dunkel ◽  
Ilpo Huhtaniemi
Keyword(s):  
Serum Testosterone ◽  
Maximal Level ◽  
Salivary Testosterone ◽  
Non Invasive ◽  
Basal Serum ◽  
Age Related ◽  
Invasive Method ◽  
Prepubertal Boys ◽  
The Mean

Abstract. To investigate the role of gonadotropins in postnatal testicular activation, testosterone responsiveness to human chorionic gonadotropin was studied in 11 male infants (aged 5-180 days). The boys were given a single im injection of 5000 IU/1.7m2 hCG, and serum and salivary testosterone responses were then measured for 7 days. The results were compared with the serum testosterone responses of 8 older prepubertal boys (aged 1.7-10.4 years) studied with the same protocol. The mean (±sem) basal serum testosterone levels were 2.67±1.27 nmol/l in the infants and 0.09±0.02 nmol/l in the prepubertal boys (p<0.05). Both groups gave a significant response to hCG stimulation (p<0.001, ANOVA, one-way). The stimulated concentrations of serum testosterone were higher in the infants than in the prepubertal boys (p<0.001). The mean basal level of salivary testosterone was 30.5 ±7.0 and the mean maximal level was 97± 10.3 pmol/l in the infants (p<0.001). No age-related changes were observed in either basal or hCG-stimulated levels. In infants the mean (±sem) maximal hCG-stimulated increase was 25 ± 10-fold in serum and 8±4-fold in saliva (p=0.13). A clear stimulatory effect of hCG on testicular testosterone production was found, suggesting that the postnatal increase in serum testosterone concentration in male infants is gonadotropin-mediated. Salivary testosterone concentrations can be increased by hCG, indicating that measurements of salivary testosterone may provide an optional, non-invasive method for assessing gonadal function in children.

Basal and TRH stimulated serum levels of TSH in patients with hyperprolactinaemia and in subjects on oestrogen treatment

1983 ◽  
Vol 102 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Eva M. Erfurth ◽  
Pavo Hedner ◽  
Anders Nilsson
Keyword(s):  
Serum Level ◽  
Serum Levels ◽  
Plasma Prolactin ◽  
Thyroid Antibodies ◽  
Elevated Plasma ◽  
Oestrogen Treatment ◽  
Pituitary Dysfunction ◽  
Basal Serum ◽  
The Mean ◽  
Serum Tsh

Abstract. In 21 hyperprolactinaemic patients without other signs of pituitary dysfunction the mean basal serum level of TSH was 4.4 ± 0.47 μU/ml that was significantly (P < 0.001) higher than controls (2.5 ± 0.16 μU/ml and oestrogen treated individuals (2.4 ± 0.29 μU/ml). The TSH increase was more pronounced (P < 0.05) in hyperprolactinaemic patients without sellar enlargement and with moderately elevated plasma prolactin levels (155 ± 42 μg/ml) than in patients with sellar enlargement and higher plasma prolactin levels (857 ± 306 μg/ml). The serum levels of thyroxine and triiodothyronine in the hyperprolactinaemic patients did not differ significantly from controls. Patients with thyroid antibodies were excluded. The increased basal serum level of TSH in hyperprolactinaemia is compatible with the concept of a reduced dopaminergic tonus as the mechanism for both changes. In patients with advanced hyperprolactinaemia and sellar enlargement the high prolactin level may induce some inhibition of TSH release and explain their lower basal serum level of TSH that was probably not due to pituitary compression as they responded normally to TRH. The TSH response to TRH was significantly (P < 0.05) correlated to the basal serum TSH in all groups. The regression lines were very similar for hyperprolactinaemic patients and controls suggesting that in hyperprolactinaemia the thyrotroph has not changed its mode of response to TRH. In contrast, oestrogen treated subjects in addition to dependence on basal serum TSH levels showed a genuinely augmented response to TRH (164.6 ± 20.3%, P < 0.01) compared to controls.

Low basal thyrotropin with normal thyroid function in primary hyperparathyroidism

1989 ◽  
Vol 121 (5) ◽  
pp. 638-642 ◽  
Author(s):  
Clementine Gillet ◽  
Pierre Bergmann ◽  
Dominique Francois ◽  
Jean-Jacques Body ◽  
Jacques Corvilain
Keyword(s):  
Primary Hyperparathyroidism ◽  
Thyroid Function ◽  
Serum Calcium ◽  
Normal Subjects ◽  
Serum Levels ◽  
Normal Thyroid Function ◽  
Basal Serum ◽  
Highly Correlated ◽  
Serum Tsh ◽  
Age And Sex

Abstract. TSH serum levels and thyroid function in 32 patients with primary hyperparathyroidism and hypercalcemia were compared to those of 30 age and sex-matched normal subjects. Serum T3 and T4 concentrations in hyperparathyroidism were not different from normal. However, basal serum TSH concentrations measured with an ultrasensitive immunoradiometric assay were significantly lower than normal (1.09 ± 0.49 vs 2.06 ± 0.85 mU/l, p < 0.001). In hyperparathyroidism, TSH, but not T4 or T3, was negatively correlated with serum calcium, not with iPTH. The increase in TSH (Δ TSH) 30 min after the iv injection of TRH was also significantly blunted in patients with primary hyperparathyroidism; Δ TSH was highly correlated with basal TSH in hypercalcemic patients. The basal TSH concentration was higher and no longer different from normal (1.70 ± 1.2 mU/l) 2 to 12 months after removal of the parathyroid adenoma, when serum calcium was normalized, whereas T3 and T4 did not change. A low basal TSH with normal T4 and low T3 was found in 13 patients with hypercalcemia of malignancy. In these patients, TSH increased after treatment of hypercalcemia with 3-amino-1,hydroxypropylidene-1,1-bisphosphonate, whereas T4 did not change. The results suggest that the set point of pituitary thyroid feedback control could be decreased in chronic hypercalcemia and that hypercalcemia could render the thyroid more sensitive to TSH.

Changes in pituitary and thyroid function with increasing age in young male rats.

1979 ◽  
Vol 237 (3) ◽  
pp. E224 ◽  
Author(s):  
F Azizi
Keyword(s):  
Thyroid Function ◽  
Subcutaneous Administration ◽  
Young Male ◽  
Thyroid Stimulating Hormone ◽  
Male Rats ◽  
Progressive Decline ◽  
Basal Serum ◽  
Serum T4 ◽  
Serum Tsh ◽  
Bovine Tsh

As the age of young adult male rats increased from 30 to 150 days, the serum thyroxine (T4) decreased by 50% and the serum thyroid-stimulating hormone (TSH) increased by 250%. There was no change in the serum triiodothyronine (T3). The increment in serum TSH after injection of thyrotropin-releasing hormone (TRH) was not significantly different at any of the ages studied, but the old animals had significantly lower increments in serum T4 and T3 after subcutaneous administration of bovine TSH. Despite a higher basal serum TSH, the older rats had a lesser increase in serum TSH after thyroidectomy or propylthiouracil. Thus, 1) there is a progressive decline in intrinsic thyroid function between 30 and 150 days of age in male rats, and 2) pituitary TSH response to fall in serum concentration of thyroid hormones is also decreased with age.

Thyroid Stimulating Hormone Measurement by an Ultrasensitive Assay during Thyroxine Replacement: Comparison with other Tests of Thyroid Function

1987 ◽  
Vol 24 (6) ◽  
pp. 614-619 ◽  
Author(s):  
T Wheatley ◽  
P M S Clark ◽  
J D A Clark ◽  
P R Raggatt ◽  
O M Edwards
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Biochemical Tests ◽  
Basal Serum ◽  
Total Thyroxine ◽  
Thyroxine Replacement ◽  
Thyroxine Replacement Therapy ◽  
Serum Tsh ◽  
Stimulating Hormone

Serum thyroid stimulating hormone (TSH) was measured using a highly sensitive enzyme-amplified immunoassay in 37 clinically euthyroid patients receiving thyroxine replacement therapy and compared with other biochemical tests of thyroid function. A highly significant correlation ( P<0·001) was found between the basal serum TSH and the increase in serum TSH concentration 20 min after the administration of thyrotropin releasing hormone (TRH). The basal serum TSH was negatively correlated with the serum total thyroxine ( P=0·05). When patients results were classified as abnormal or normal many discrepancies were noted between the various thyroid tests. A suppressed serum TSH was found in 65% of patients with a normal serum total thyroxine. However, in patients on thyroxine replacement therapy a basal TSH measured by enzyme-amplified immunoassay provides the same information as a TRH test.

Endocrine effects of high-dose ketoconazole therapy in advanced prostatic cancer

1985 ◽  
Vol 110 (2) ◽  
pp. 276-283 ◽  
Author(s):  
W. Heyns ◽  
A. Drochmans ◽  
E. van der Schueren ◽  
G. Verhoeven
Keyword(s):  
Serum Concentration ◽  
Prostatic Cancer ◽  
Inverse Correlation ◽  
Serum Testosterone ◽  
Feedback System ◽  
Sex Hormone Binding Globulin ◽  
High Dose ◽  
Endocrine Effects ◽  
Advanced Prostatic Cancer ◽  
The Mean

Abstract. The endocrine effects of ketoconazole (400 mg orally every 8 h) were studied in 9 previously untreated patients with advanced prostatic cancer. Five of these patients were followed for 12 months. A rapid fall in the serum concentration of testosterone was noted in all patients studied. Minimal values were observed on day 4 of treatment but thereafter serum testosterone increased slowly. The effect of the drug on unbound testosterone was relatively more important, since sex hormone binding globulin increased markedly during treatment. An increase in progesterone and LH was observed in all patients. This suggests that ketoconazole limits the conversion of C21-precursors into androgens. This block is compensated in part by activation of the hypothalamo-hypophyseal feedback system. Urinary 17-ketosteroids were decreased but 17-hydroxysteroids were unaffected by the treatment. In 5 patients followed monthly over a period of 12 months the mean testosterone concentration ranged from 69 ng/100 ml in one patient to 428 ng/100 ml in another. An excellent inverse correlation could be demonstrated between the mean serum concentration of testosterone and the mean concentration of ketoconazole. The change of serum dehydroepiandrosterone sulphate also correlated inversely with the mean ketoconazole level. Increased concentrations of oestradiol were noted in 2 patients with slight gynaecomastia. It is concluded that long-term suppression of androgen production can be realized by high-dose ketoconazole treatment and that the degree of suppression is proportional to the serum levels of the drug.

THE GONADOTROPHIN RESPONSE TO SYNTHETIC GONADOTROPHIN-RELEASING HORMONE IN MALES IN RELATION TO AGE, DOSE, AND BASAL SERUM LEVELS OF TESTOSTERONE, OESTRADIOL-17β AND GONADOTROPHINS

1974 ◽  
Vol 77 (4) ◽  
pp. 625-635 ◽  
Author(s):  
E. Haug ◽  
A. Aakvaag ◽  
T. Sand ◽  
P. A. Torjesen
Keyword(s):  
Dose Response ◽  
Response Curve ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Releasing Hormone ◽  
Testosterone Levels ◽  
Basal Serum ◽  
Gonadotrophin Releasing Hormone ◽  
The Mean ◽  
Male Subjects

ABSTRACT Three healthy male volunteers, 28–35 years old, were given an intravenous dose of 12.5, 25, 100, 200, 400, 800, and 1200μg of synthetic gonadotrophin-releasing hormone (LH/FSH-RH) in order to determine the dose-response relationship. The resulting log dose-response curve between interstitial-cell stimulating hormone (ICSH) and LH/FSH-RH was approximately linear between the 12.5 and 400 μg doses. The smallest dose that significantly (P < 0.05) increased the mean serum ICSH levels was 25 μg, and 400 μg of LH/FSH-RH was the minimum dose that produced the maximum ICSH response. The increments in serum follicle-stimulating hormone (FSH) were much less than the corresponding serum ICSH increments, and the log dose-response curve was not linear. The effect of increasing age on the gonadotrophin response to LH/FSH-RH was studied in 50 male subjects, 20–89 years old, without evidence of endocrine disease. They were given 100μg of LH/FSH-RH each. A reduction in the mean response for both ICSH and FSH was observed after the age of 70, and this was most clearly seen in the group of males 80–89 years old. Therefore the interpretation of the LH/FSH-RH tests, at least in males, will require age-specific ranges of normal ICSH and FSH responses. Serum testosterone levels were determined in 48 of the male subjects investigated, and the mean serum levels remained within the same range (above 0.60 μg/100 ml) from the age of 20 to the age of 79 years. In the age group 80–89 years, the mean serum testosterone was reduced to 0.39 μg/100 ml. Serum oestradiol-17β was determined in 44 of the males, and there were no significant differences between the mean levels of the different age groups (45–55 pg/ml). There was no significant age-dependent change in basal serum ICSH and FSH levels. It is concluded that there is a parallel decrease in serum testosterone levels and in serum gonadotrophin responses to LH/FSH-RH after the age of 70. These findings would suggest that the decrease in serum testosterone levels is the result of reduced stimulation of the testicular tissue with endogenous gonadotrophins.

scholarly journals The study of correlation between thyroid function and blood pressure in hypertensive patients attending out patient department in tertiary care centre

2020 ◽  
Vol 8 (3) ◽  
pp. 868
Author(s):  
Aparna Patange ◽  
Harsh Shah ◽  
Harshil Vora
Keyword(s):  
Blood Pressure ◽  
Thyroid Function ◽  
Tertiary Care ◽  
Endocrine Disorders ◽  
Tertiary Care Centre ◽  
Mean Values ◽  
Serum T3 ◽  
Serum T4 ◽  
The Mean ◽  
Serum Tsh

Background: Hypertension may be the initial clinical presentation for at least 15 endocrine disorders, including overt and subclinical hyperthyroidism and hypothyroidism. The correction of thyroid dysfunction may normalize Blood Pressure (BP) in most cases, therefore checking thyroid function is essential during the workup for hypertension. The present study was conducted to find out the association between hypertension and thyroid dysfunction.Methods: It was a retrospective, observational study conducted among patients having hypertension visiting the outpatient department of Medicine in KIMS Karad, during the period of 2 months.Results: The mean values of various thyroid function parameters among hypertensive cases was assessed in the current study, Authors found that the mean Serum T3 level was 93.5917±32.82, Mean Serum T4 level was 6.72±1.64 and the mean Serum TSH level was 2.52±2.71. Among all the cases about 52% cases had deranged thyroid function reports.Conclusions: The results of this study suggest an association between subclinical hypothyroidism and increased blood pressure levels.

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