URINARY EXCRETION OF CALCIUM, HYDROXYPROLINE AND 3′,5′-CYCLIC ADENOSINE MONOPHOSPHATE IN PRIMARY HYPERPARATHYROIDISM

1979 ◽  
Vol 92 (1) ◽  
pp. 138-147 ◽  
Author(s):  
Johan Halse ◽  
Jan O. Gordeladze
Keyword(s):  
Food Intake ◽  
Primary Hyperparathyroidism ◽  
Urinary Excretion ◽  
Diurnal Variation ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Parathyroid Surgery ◽  
Creatinine Ratio ◽  
Parathyroid Function ◽  
The Individual

ABSTRACT Urinary excretion of calcium (Ca), hydroxyproline (Hyp) and 3′,5′-cyclic adenosine monophosphate (cAMP) was measured during fasting, and in the afternoon, over a 3 day period. Twelve hyperparathyroid patients, of whom 6 were re-studied after successful parathyroid surgery, and 10 control subjects participated, and were maintained on a collagen free diet for the duration of the study. Expressed as creatinine ratio values, Hyp was significantly higher in the morning than during the afternoon, whereas the Ca excretion pattern showed low morning and high afternoon values for all groups. cAMP excretion did not change during the two sampling periods. Large day to day variations for each parameter were observed in the individual patient. The value of cAMP measurements in the diagnosis of primary hyperparathyroidism was confirmed. The results may imply that a diurnal variation in Hyp excretion exists in primary hyperparathyroidism and that food intake produces a suppression of Hyp excretion, possibly secondary to suppression of parathyroid function or, in our view, to increased calcitonin excretion.

Renal cyclic adenosine monophosphate: An accurate index of parathyroid function

Metabolism ◽  
1976 ◽  
Vol 25 (10) ◽  
pp. 1103-1112 ◽  
Author(s):  
Marc K. Drezner ◽  
Francis A. Neelon ◽  
Holly B. Curtis ◽  
Harold E. Lebovitz
Keyword(s):  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Parathyroid Function

scholarly journals Nephrogenous Cyclic Adenosine Monophosphate as a Parathyroid Function Test

1977 ◽  
Vol 60 (4) ◽  
pp. 771-783 ◽  
Author(s):  
Arthur E. Broadus ◽  
Jane E. Mahaffey ◽  
Frederic C. Bartter ◽  
Robert M. Neer
Keyword(s):  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Parathyroid Function ◽  
Function Test

scholarly journals Effect of Electric Convulsion Therapy on Urinary Excretion of 3', 5' Cyclic Adenosine Monophosphate

BMJ ◽  
1972 ◽  
Vol 3 (5824) ◽  
pp. 439-441 ◽  
Author(s):  
K. Hamadah ◽  
H. Holmes ◽  
G. B. Barker ◽  
G. C. Hartman ◽  
D. V. W. Parke
Keyword(s):  
Urinary Excretion ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate

scholarly journals Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure: Relationship to Food Intake

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Xiuhai Ren ◽  
Kabirullah Lutfy ◽  
Michael Mangubat ◽  
Monica G. Ferrini ◽  
Martin L. Lee ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Day Treatment ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Brain Regions ◽  
Dorsomedial Nucleus ◽  
Chronic Morphine ◽  
Regulate Food Intake ◽  
Phosphorylated Creb

Background. Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.Methods. Given that opioids regulate food intake, we measured P-CREB in different brain regions in mice exposed to morphine treatments designed to induce different degrees of tolerance and dependence.Results. We found that a single morphine injection or daily morphine injections for 8 days did not influence P-CREB levels, while the escalating dose of morphine regimen raised P-CREB levels only in the ventral tegmental area (VTA). Chronic morphine pellet implantation for 7 days raised P-CREB levels in the LH, VTA, and dorsomedial nucleus of the hypothalamus (DM) but not in the nucleus accumbens and amygdala. Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight.Conclusion. The morphine regulation of P-CREB may explain some of the physiological sequelae of opioid exposure including altered food intake and body weight.

Lack of Effect of Fluoride on Urinary cAMP Excretion in Rats

1979 ◽  
Vol 58 (10) ◽  
pp. 2036-2039 ◽  
Author(s):  
R.H. Ophaug ◽  
K.M. Wong ◽  
L. Singer
Keyword(s):  
Drinking Water ◽  
Urinary Excretion ◽  
Adenosine Monophosphate ◽  
Creatinine Ratio ◽  
Fluoride Intake

The urinary excretion of cyclic 3'5'-adenosine monophosphate (cAMP) was measured in rats provided a low fluoride diet (< 0.5 ppm) and drinking water containing either 0 or 25 ppm of fluoride. The pMole cAMP/μg creatinine ratio decreased with age but was not influenced by fluoride intake.

Intact parathyroid hormone concentration and cyclic AMP metabolism in thyroid disease

1991 ◽  
Vol 124 (6) ◽  
pp. 652-657 ◽  
Author(s):  
W. D. Fraser ◽  
F. C. Logue ◽  
K. MacRitchie ◽  
R. M. Wilson ◽  
H. W. Gray ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Elevated Serum ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Volunteer ◽  
Urinary Calcium ◽  
Intact Parathyroid Hormone ◽  
Creatinine Ratio ◽  
Intact Pth ◽  
Hypothyroid Patients

Abstract. In 35 thyrotoxic patients and 35 patients receiving thyroxine replacement therapy mean serum intact parathyroid hormone concentrations were lower than in euthyroid normal volunteer controls. In 20 hypothyroid patients intact PTH was increased relative to euthyroid controls. Mean serum adjusted calcium was increased in thyrotoxic patients relative to euthyroid controls and in 8 toxic patients with elevated serum adjusted calcium (>2.60 mmol/l) intact PTH was below the assay detection limit (<0.5 pmol/l). Indices of PTH activity were consistent with intact PTH measurements in thyrotoxic patients with nephrogenous cyclic adenosine monophosphate lower, tubular maximum reabsorption of phosphate higher, and urinary calcium creatinine ratio higher than controls. In hypothyroid patients these indices of PTH activity suggest relative end organ resistance to PTH with nephrogenous cyclic adenosine monophosphate similar, tubular maximum reabsorption of phosphate similar, and calcium creatinine ratio lower than in controls. In treated hypothyroid patients nephrogenous cyclic adenosine monophosphate was higher, tubular maximum reabsorption of phosphate similar, and calcium creatinine ratio higher than in controls. These results are compatible with the hypothesis that thyroid status modifies the renal responses to PTH (1-84).

Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects

1981 ◽  
Vol 96 (4) ◽  
pp. 451-457 ◽  
Author(s):  
Johan Halse ◽  
Jan O. Gordeladze
Keyword(s):  
Urinary Excretion ◽  
Formation Rate ◽  
Bone Matrix ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Control Subjects ◽  
Urinary Parameters ◽  
Turn Over ◽  
And Control ◽  
Calcium Phosphate Metabolism

Abstract. The urinary excretion of total and non-dialyzable hydroxyproline (HYP) containing peptides has been studied in 25 patients with active acromegaly and 44 control subjects — all kept on a collagen free diet. Acromegalics had a greater excretion of both total and non-dialyzable HYP than controls, indicating an increased turn-over of collagen/bone matrix. The amounts of total and non-dialyzable HYP excreted in acromegalics were significantly correlated to mean fasting growth hormone levels. Both acromegalics and controls exhibited a significant coupling between the excretion of total and non-dialyzable HYP. Female control subjects demonstrated an age-dependent decrease in the excretion of both total and non-dialyzable HYP, whereas no such age-dependence could be observed in males. Age seemed to have a greater effect on the non-dialyzable fraction than on the total HYP excretion. These results may imply that collagen/bone matrix turn-over declines with age and that bone formation declines at a more rapid rate than resorption. In acromegalics the ratio of non-dialyzable to dialyzable HYP was not significantly different from control values, indicating that although turn-over is increased the actual matrix formation rate is normal in acromegaly. No correlation was found between serum or urinary parameters of calcium/phosphate metabolism or the urinary excretion of 3',5'-cyclic adenosine monophosphate and total or non-dialyzable HYP in acromegalics or controls.

Effect of 25(OH)vitamin D3 on urinary excretion of cyclic adenosine monophosphate

1975 ◽  
Vol 229 (4) ◽  
pp. 907-910 ◽  
Author(s):  
MM Popovtzer ◽  
JB Robinette
Keyword(s):  
Urinary Excretion ◽  
Continuous Infusion ◽  
Vitamin D3 ◽  
Cyclic Adenosine Monophosphate ◽  
Fractional Excretion ◽  
Adenosine Monophosphate ◽  
Renal Handling ◽  
Control Value ◽  
Group 1 ◽  
Intact Rats

To further evaluate the effect of 25(OH)vitamin D3 (25(OH)vit D3) on renal handling of phosphorus, fractional excretion of phosphorus (CP/CIn) and urinary excretion of cyclic AMP (UcAMP) were measured in the following groups of animals: 1) intact rats receiving intravenously 25(OH)vit D3. 2a) Parathyroidectomized (PTX) rats receiving a continuous infusion of parathyroid hormone (PTH). 2b) PTX rats undergoing continuous infusion of PTH and receiving intravenously 25(OH)vit D3. In group 1 a decrease in CP/CIn from a control value of 0.210 +/- 0.064 (kappa +/- SE) to 0.052 +/- 0.017 (P less than 0.001) during 25(OH)vit D3 infusion was associated with a corresponding decrease in UcAMP from 182 +/- 18 to 87 +/- 8 pmol/min (P less than 0.001). In group 2a an increase in CP/CIn from a control value of 0.031 +/- 0.014 to 0.365 +/- 0.017 during PTH infusion was associated with a corresponding increase in UcAMP from 76 +/- 17 to 330 +/- 51 pmol/min (P less than 0.001). In group 2b a decrease in CP/CIn from 0.365 +/- 0.017 to 0.256 +/- 0.011 (P less than 0.01) during 25(OH)vit D3 infusion was associated with a decrease in UcAMP from 356 +/- 63 to 191 +/- 33 pmol/min (P less than 0.01). These results indicate that the blunting of the phosphaturic response to PTH by 25(OH)vit D3 is associated with a decrease in UcAMP. This observation suggests that the mechanism underlying the enhanced tubular reabsorption of phosphorus is inhibition of the PTH-induced activation of adenylate cyclase in the kidney.

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