OBSERVATIONS ON THE TREATMENT OF YOUNG DIABETICS WITH AN ORAL DRUG (PHENETHYL-BIGUANIDE)

1959 ◽  
Vol XXXII (IV) ◽  
pp. 491-496 ◽  
Author(s):  
Robert S. Walker ◽  
Adam L. Linton
Keyword(s):  
Juvenile Diabetes ◽  
Oral Drug ◽  
List Type ◽  
Juvenile Diabetics ◽  
Oral Hypoglycaemic Drugs ◽  
Partial Success

ABSTRACT A brief comparison of phenethyl-biguanide (D. B. I.) with other oral hypoglycaemic drugs is made. A series of 31 juvenile diabetics treated with D. B. I. is described, and the reasons for partial success or failure are considered. The advantages and dangers of the drug are discussed. It is concluded that the unique action of this drug may give it a place in the treatment of juvenile diabetes.

IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT

1974 ◽  
Vol 75 (1) ◽  
pp. 50-63 ◽  
Author(s):  
Kristian F. Hanssen
Keyword(s):  
Growth Hormone ◽  
Insulin Treatment ◽  
Juvenile Diabetes ◽  
Control Group ◽  
List Type ◽  
Newly Diagnosed ◽  
Renal Tubular Reabsorption ◽  
Juvenile Diabetics ◽  
The Mean ◽  
Renal Tubular

ABSTRACT Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment. The plasma IRHGH was significantly higher (0.05 > P > 0.01) before than during initial insulin treatment. During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 > P > 0.001) than in a control group. The urinary IRHGH was significantly higher (0.01 > P > 0.001) before than during insulin treatment. The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone. No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.

Congratulations on a Useful Article

PEDIATRICS ◽  
1974 ◽  
Vol 54 (3) ◽  
pp. 387-387
Author(s):  
George M. Johnson
Keyword(s):  
Diabetes Mellitus ◽  
Juvenile Diabetes ◽  
Urine Glucose ◽  
Juvenile Diabetes Mellitus ◽  
The Past ◽  
Juvenile Diabetics ◽  
Juvenile Diabetic

Forman, Goldstein and Gonel are to be congratulated for their important, succinct paper, "Management of Juvenile Diabetes Mellitus: Usefulness of 24-Hour Fractional Quantitative Urine Glucose" (Pediatrics, 53:257, 1974). For the past five years, on the recommendation of Dr. Donnell B. Etzwiler, we have followed approximately 60 juvenile diabetics using fractional quantitative 24-hour urine glucose values (obtained three or four times a year). As the authors point out, it is unfortunate and often detrimental to the juvenile diabetic that this simple inexpensive test has not gained wide clinical acceptance or even consideration by the physician caring for the juvenile diabetic.

scholarly journals It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine

Breathe ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 210005
Author(s):  
Anneka Sareen ◽  
Manisha Ramphul ◽  
Jayesh Mahendra Bhatt
Keyword(s):  
Cystic Fibrosis ◽  
Survival Rates ◽  
Paediatric Population ◽  
Oral Medication ◽  
Respiratory Medicine ◽  
Oral Drug ◽  
List Type ◽  
Treatment Burden ◽  
Oral Medications ◽  
Oral Formulations

Advances in therapies and management of conditions encountered by paediatric respiratory specialists have led to improved outcomes and improved survival rates dramatically in chronic diseases such as cystic fibrosis. However, this has also meant an increase in treatment burden. A variety of inhaled treatments are crucial in managing paediatric respiratory diseases, but these patients also have to take many oral medications. It is widely recognised that developing oral formulations appropriate for the paediatric population can affect how well a product is received by patients and their families. Consideration should be given to palatability and the number of medicines to be administered as these can all contribute to treatment adherence.Polypharmacy specifically in the context of management of patients with cystic fibrosis is not a new concept, but the recently introduced cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and their potential for interactions and adverse reactions create novel challenges. There are some strategies that families and healthcare professionals can implement to reduce treatment burden. This review will also provide some insight into the life of a teenager with cystic fibrosis and the relative complexities of her treatment and the impacts on daily life.Educational aimsTo describe the difficulties faced by children with long-term respiratory conditions having to take oral medication.To discuss oral drug interactions that may exist within paediatric respiratory medicine and to consider issues with polypharmacy.To highlight strategies that may be used to reduce the burden of care for children on oral medication.

EARLY INSULIN RESPONSE TO GLUCOSE STIMULATION IN SIBLINGS OF JUVENILE DIABETICS

1973 ◽  
Vol 73 (4) ◽  
pp. 721-730 ◽  
Author(s):  
Göran Sterky ◽  
Jan I. Thorell
Keyword(s):  
Glucose Tolerance ◽  
Insulin Response ◽  
Monozygotic Twins ◽  
Skinfold Thickness ◽  
Juvenile Diabetes ◽  
Intravenous Glucose Tolerance Test ◽  
Intravenous Glucose ◽  
Significant Difference ◽  
Juvenile Diabetics ◽  
Early Insulin Response

ABSTRACT An intravenous glucose tolerance test was carried out in 33 young sibs of juvenile diabetics and in 53 matched controls. No significant difference was found in blood glucose, glucose disappearance rate or FFA response between the two groups. The variation of the early insulin response (ER) was wide, but the mean (±sd) was significantly lower for the sibs (71 ±41 μU/ml) than for the controls (116 ± 58 μU/ml). This difference was due mainly to the fact that high ER was almost lacking among the sibs, while low or medium ER occurred in both groups. No correlation was found between ER and age (12–26 years), body weight or skinfold thickness. The ER and the glucose disapperance rates were positively correlated. The healthy brother and sister, respectively, in two pairs of monozygotic twins, whose sibs had juvenile diabetes, showed normal glucose tolerance and a normal ER (58 and 103 μU/ml) falling within 1 sd of the normals. The results lend support to the view that the ER is affected by close kinship to juvenile diabetics, revealed by group comparison. The results do not indicate that individual »pre-diabetics« can be identified by a low ER.

C-PEPTIDE IN DIABETIC CHILDREN AFTER STIMULATOIN WITH CLUCAGON COMPARED WITH FASTING C-PEPTIDE LEVELS IN NON-DIABETIC CHILDREN

1977 ◽  
Vol 85 (2) ◽  
pp. 364-371 ◽  
Author(s):  
J. Ludvigsson ◽  
L. G. Heding
Keyword(s):  
Metabolic Control ◽  
Cell Function ◽  
Juvenile Diabetes ◽  
Significant Rise ◽  
Immunoreactive Insulin ◽  
C Peptide ◽  
Peptide Level ◽  
Diabetic Children ◽  
Insulin Dependent ◽  
Juvenile Diabetics

ABSTRACT Fasting serum C-peptide and total immunoreactive insulin (IRI) were determined in 38 non-diabetic children and adolescents 6–22 years old. C-peptide varied between 0.22–0.73 pmol/ml (mean ± sd, 0.45 ± 0.11). There was a tendency to higher values during puberty. No difference was found between subjects with or without a family history for diabetes. IRI varied between 0–31 μU/ml (mean ± sd, 11.3 ± 6.5). The C-peptide response to glucagon was studied in 10 insulin dependent juvenile diabetics 11–19 years old, who had had measurable amounts of fasting C-peptide on some occasions during the previous years. Duration of diabetes varied between 4–12 years. A slight but significant rise in C-peptide level occurred in 3 patients. Their metabolic control estimated on the basis of daily urinalysis was "excellent" or "good". The results support the hypothesis that even trace remnants of the beta cell function may be of importance for the metabolic control in juvenile diabetes.

Management Of Juvenile Diabetes Mellitus, by Howard S. Traisman, M.D., ed. 2, St. Louis, Missouri: C. V. Mosby Company, 1971, 223 pp., $19.75

PEDIATRICS ◽  
1973 ◽  
Vol 51 (1) ◽  
pp. 162-162
Author(s):  
J. Chukwuemeka Azubuike
Keyword(s):  
Diabetes Mellitus ◽  
Juvenile Diabetes ◽  
Medical Progress ◽  
Juvenile Diabetes Mellitus ◽  
Juvenile Diabetics

Dr. Traisman assumes complete responsibility for the second edition of this book; the first edition with Dr. Newcomb as co-author was published in 1965. About 70 pages have been added because of the inclusion of a few new chapters; these deal with the pathogenesis of diabetes mellitus, transplantation of the pancreas for this disease, the psychologic aspects of diabetes, and with hypoglycemia. The latter two chapters are most welcome in this day and age when medical progress is helping to prolong the lives of juvenile diabetics.

STUDIES IN CONGENITAL GENERALIZED LIPODYSTROPHY

1976 ◽  
Vol 83 (4) ◽  
pp. 839-855 ◽  
Author(s):  
Svein Oseid ◽  
Esther D. R. Pruett
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose Concentration ◽  
Human Growth ◽  
Normal Subjects ◽  
Juvenile Diabetes ◽  
Congenital Generalized Lipodystrophy ◽  
Normal Individuals ◽  
Juvenile Diabetics ◽  
Diabetes Development ◽  
The One

ABSTRACT Two patients with congenital generalized lipodystrophy have been studied at rest, and during and after long-term exercise at different carefully measured work loads. The two patients represented different stages of diabetes development. Both patients derived most of their energy used during muscular exercise from carbohydrate, and comparatively little from fat. FFA levels remained low throughout the period of observation in contrast to normal individuals and patients with juvenile diabetes. The data presented seem to show that deposition of glucose and free fatty acids (FFA) as triglyceride, must be impaired and are not compatible with the concept of increased triglyceride turnover in the adipocytes. The fall in blood glucose concentration (BCG) was less than in normal individuals and juvenile diabetics during exercise, and the glucose tolerance remained unchanged following work stop in both patients (k-values unchanged), in contrast to normal persons and patients with juvenile diabetes. Both patients showed significant falls in circulating immuno-reactive insulin (IRI) levels during exercise irrespective of a rise or fall in BGC. Thus, the exercise itself might activate endogenous mechanisms which could, on the one hand increase the circulating BGC, and at the same time force circulating IRI to decrease, thus disturbing the well-known relationship between circulating glucose and IRI levels as has been exhibited in normal subjects. The high IRI levels, also during exercise in these patients, indicate a' relative insulin resistance in the muscles, but less marked than the insulin resistance in the adipose tissue. The IRI response after glucose infusion did not change significantly with increasing work loads with one exception. Exercise did not alter significantly the human growth hormone (HGH) levels in either the diabetic or the non-diabetic patient indicating an abnormal regulation of the HGH secretion in congenital lipodystrophy.

Book Reviews

Tempo ◽  
1995 ◽  
pp. 29-36
Keyword(s):  
List Type

Volume I of Messiaen's ‘Traite’, ‘Music and Color’, and organ recordings Christopher DingleRobert Craft's Stravinsky memoirs and recordings Rodney Lister

Open discussion

1982 ◽  
Vol 99 ◽  
pp. 605-613
Author(s):  
P. S. Conti
Keyword(s):  
Buenos Aires ◽  
Large Mass ◽  
List Type ◽  
Common Phenomenon ◽  
Open Discussion ◽  
The Stability ◽  
Ring Nebulae

Conti: One of the main conclusions of the Wolf-Rayet symposium in Buenos Aires was that Wolf-Rayet stars are evolutionary products of massive objects. Some questions:–Do hot helium-rich stars, that are not Wolf-Rayet stars, exist?–What about the stability of helium rich stars of large mass? We know a helium rich star of ∼40 MO. Has the stability something to do with the wind?–Ring nebulae and bubbles : this seems to be a much more common phenomenon than we thought of some years age.–What is the origin of the subtypes? This is important to find a possible matching of scenarios to subtypes.

Solar Corona Investigation by the Coronal Line Photometer at Lomnický Peak

1994 ◽  
Vol 144 ◽  
pp. 431-434
Author(s):  
M. Minarovjech ◽  
M. Rybanský
Keyword(s):  
Solar Corona ◽  
Time Resolution ◽  
Active Regions ◽  
High Time ◽  
High Time Resolution ◽  
List Type ◽  
Type Number ◽  
Coronal Line ◽  
Global Cycle

AbstractThis paper deals with a possibility to use the ground-based method of observation in order to solve basic problems connected with the solar corona research. Namely:1.heating of the solar corona2.course of the global cycle in the corona3.rotation of the solar corona and development of active regions.There is stressed a possibility of high-time resolution of the coronal line photometer at Lomnický Peak coronal station, and use of the latter to obtain crucial observations.

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