THE INFLUENCE OF VITAMIN C ON EOSINOPHIL RESPONSE TO ACUTE ALCOHOL INTOXICATION IN RATS

1960 ◽  
Vol XXXV (IV) ◽  
pp. 585-593 ◽  
Author(s):  
T. P. J. Vanha-Perttula
Keyword(s):  
Vitamin C ◽  
Ethyl Alcohol ◽  
Intraperitoneal Injection ◽  
Alcohol Intoxication ◽  
Albino Rats ◽  
Acute Alcohol Intoxication ◽  
Alcohol Administration ◽  
Initial Values

ABSTRACT The effect of ethyl alcohol on the circulating eosinophil cells has been studied in female albino rats. An intoxicating dose of alcohol caused a marked depletion of circulating eosinophils which was most clearly evident four hours after the administration of the alcohol. The initial values were not reached before 24 hours had elapsed. Intraperitoneal injection of vitamin C 12 hours prior to the alcohol administration very effectively prevented this eosinopenic reaction. The mechanism of regulation of the eosinophil cells in the circulation has been discussed in the light of previous results and of those obtained in this study.

ALCOHOL-INDUCED HYPOGLYCEMIA AND COMA CAUSED BY ALCOHOL SPONGING

PEDIATRICS ◽  
1970 ◽  
Vol 46 (3) ◽  
pp. 445-447
Author(s):  
Malcolm H. Moss
Keyword(s):  
Blood Glucose ◽  
Elevated Temperature ◽  
Ethyl Alcohol ◽  
Alcohol Intoxication ◽  
Severe Hypoglycemia ◽  
Male Infant ◽  
Blood Alcohol ◽  
Acute Alcohol Intoxication ◽  
Tepid Water

The inhalation of ethyl or isopropylalcohol vapor during sponge bathing may result in alcohol intoxication and coma. Ingestion of these alcohols may cause hypoglycemia in children or adults. The present case is the first reported in which alcohol-induced hypoglycemia developed following inhalation of alcohol. A six month-old male infant became comatose following sponge bathing with ethyl alcohol. He was found to have acute alcohol intoxication (blood alcohol 220 mg per 100 ml) and severe hypoglycemia (blood glucose 22 mg per 100 ml). The administration of 50% glucose in water intravenously resulted in prompt recovery. Alcohol sponging to lower elevated temperature is rarely necessary. Cooling with tepid water is effective and considerably less hazardous; the addition of alcohol is not necessary.

scholarly journals Effect of acute alcohol intoxication on granulocyte mobilization and kinetics

Blood ◽  
1978 ◽  
Vol 52 (3) ◽  
pp. 551-559
Author(s):  
SJ Gluckman ◽  
RR MacGregor
Keyword(s):  
Bone Marrow ◽  
Heat Loss ◽  
Alcohol Intoxication ◽  
Acute Alcohol Intoxication ◽  
Endotoxin Administration ◽  
Alcohol Administration ◽  
Human Volunteers ◽  
Normal Controls ◽  
Bone Marrow Granulocytes

Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication (45,-800 cells in 8 hr versus 353,000 in normal controls). Alcohol applied locally did not inhibit granulocyte delivery, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers. Intoxication inhibited granulocyte adherence and local mobilization in parallel. Alcohol administration to rabbits shifted granulocytes from marginal to circulating pool in a manner similar to epinephrine. Mobilization of bone marrow granulocytes by glucocorticoid or endotoxin administration was not inhibited by intoxication, nor did it prevent the endotoxin-induced shift of granulocytes from circulating to marginal pool.

Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling

2005 ◽  
Vol 288 (1) ◽  
pp. H121-H128 ◽  
Author(s):  
Thomas C. Vary ◽  
Gina Deiter ◽  
Stacy A. Goodman
Keyword(s):  
Complex Formation ◽  
Alcohol Intoxication ◽  
Mammalian Target Of Rapamycin ◽  
Mrna Translation ◽  
Mtor Signaling ◽  
Initiation Factor ◽  
Translational Efficiency ◽  
Acute Alcohol Intoxication ◽  
Alcohol Administration ◽  
Mtor Phosphorylation

Acute alcohol intoxication impairs myocardial protein synthesis in rats, secondary to a diminished mRNA translational efficiency. Decreased mRNA translational efficiency occurs through altered regulation of peptide chain initiation. The purpose of the present set of experiments was to determine whether acute alcohol intoxication alters the phosphorylation state of eukaryotic initiation factor (eIF) 4G, eIF4G·eIF4E complex formation, and the mammalian target of rapamycin (mTOR) signaling pathway in the heart. Acute alcohol intoxication was induced by injection of alcohol (75 mmol/kg body wt ip). Control animals received an equal volume of saline. Alcohol administration enhanced phosphorylation of eIF4G (Ser1108) approximately threefold. Alcohol administration lowered formation of the active eIF4G·eIF4E complex by >90%, whereas it increased the abundance of the inactive 4E-binding protein 1 (4E-BP1)·eIF4E complex by ∼160%. Phosphorylation of mTOR on Ser2448 and Ser2481 was decreased by 50%. Reduced mTOR phosphorylation did not result from decreased phosphorylation of PKB. Phosphorylation of 4E-BP1 and S6 kinase 1 (Thr389), downstream targets of mTOR, were also reduced after acute alcohol administration. These data suggest that acute alcohol-induced impairments in myocardial mRNA translation initiation result, in part, from marked decreases in eIF4G·eIF4E complex formation, which appear to be independent of changes in phosphorylation of eIF4G but dependent on mTOR.

Acute Neuropsychiatric Complications of Chronic Alcoholism

1968 ◽  
Vol 114 (506) ◽  
pp. 85-92 ◽  
Author(s):  
H. G. Morgan
Keyword(s):  
Ethyl Alcohol ◽  
Alcohol Intake ◽  
Alcohol Intoxication ◽  
Chronic Alcoholism ◽  
Acute Alcohol Intoxication ◽  
Secondary Complications ◽  
Neuropsychiatric Complications ◽  
Symptoms And Signs

The effects of ethyl alcohol in man may be classified into two main groups. The first, consisting of all those symptoms and signs that can be directly attributed to the action of alcohol itself, includes all the features of acute alcohol intoxication. The second group, with which this study is concerned, consists of a wide variety of conditions which do not appear to result directly from the action of alcohol and which may be regarded as secondary complications. They occur only when excess alcohol intake has occurred over a prolonged period.

scholarly journals 2442

2017 ◽  
Vol 1 (S1) ◽  
pp. 65-65
Author(s):  
Brandi Fink ◽  
Eric D. Claus ◽  
James F. Cavanagh ◽  
Derek A. Hamilton ◽  
Sarah Salway
Keyword(s):  
Intimate Partner Violence ◽  
Emotion Regulation ◽  
Partner Violence ◽  
Alcohol Intoxication ◽  
Intimate Partner ◽  
Acute Alcohol Intoxication ◽  
Alcohol Administration ◽  
Main Effect ◽  
Alcohol Condition ◽  
History Of

OBJECTIVES/SPECIFIC AIMS: The objective of this research was to investigate the effect of alcohol and evocative stimuli on heart rate variability (HRV) in partners with a history of intimate partner violence in a placebo-controlled alcohol administration study with an emotion-regulation task. METHODS/STUDY POPULATION: In total, 17 partners (9 females, 8 males) with a history of partner violence participated in a placebo-controlled alcohol administration study with an emotion-regulation task during which HRV measures were collected. In the alcohol condition, participants were administered a mixture of 100 proof vodka and cranberry juice calculated to raise their blood alcohol concentration (BAC) to 0.08%. In the placebo condition, participants consumed a volume of juice equivalent to that consumed in the alcohol condition, but without alcohol. Alcohol and placebo conditions were counter-balanced across participants as were the presentation the blocks of evocative and neutral partner stimuli. RESULTS/ANTICIPATED RESULTS: Controlling for baseline HRV, there was a significant main effect of stimuli (evocative vs. neutral partner stimuli) on HRV in intoxicated partners, F1,16=16.28, p=0.004. There was also a significant main effect of regulation on HRV under conditions acute alcohol intoxication, F1,16=23.55, p=0.001. These effects tell us that intoxicated partners experienced reduced HRV when exposed to evocative stimuli from their partners. These effects also tell us that under acute alcohol intoxication, partners were less able to regulate their emotion when exposed to evocative stimuli than when they consumed a placebo beverage. DISCUSSION/SIGNIFICANCE OF IMPACT: These results suggest that increases in intimate partner violence under acute alcohol intoxication may be the result of reduce HRV. This reduction in HRV would contribute to partners’ inability to response with adaptively in conflict when intoxicated. They also suggest that HRV may be an important target for intervention with partner with a history of intimate partner violence. One method may be Heart Rate Variability Biofeedback which has been shown to increase parasympathetic nervous system functioning, autonomic stability, and emotion regulation.

scholarly journals Effect of acute alcohol intoxication on granulocyte mobilization and kinetics

Blood ◽  
1978 ◽  
Vol 52 (3) ◽  
pp. 551-559 ◽  
Author(s):  
SJ Gluckman ◽  
RR MacGregor
Keyword(s):  
Bone Marrow ◽  
Heat Loss ◽  
Alcohol Intoxication ◽  
Acute Alcohol Intoxication ◽  
Endotoxin Administration ◽  
Alcohol Administration ◽  
Human Volunteers ◽  
Normal Controls ◽  
Bone Marrow Granulocytes

Abstract Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication (45,-800 cells in 8 hr versus 353,000 in normal controls). Alcohol applied locally did not inhibit granulocyte delivery, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers. Intoxication inhibited granulocyte adherence and local mobilization in parallel. Alcohol administration to rabbits shifted granulocytes from marginal to circulating pool in a manner similar to epinephrine. Mobilization of bone marrow granulocytes by glucocorticoid or endotoxin administration was not inhibited by intoxication, nor did it prevent the endotoxin-induced shift of granulocytes from circulating to marginal pool.

scholarly journals The morphology of the kidney tissue structure of albino rats at the light-optical level in case of acute coronary intoxication in an experiment

2013 ◽  
Vol 17 (3 (67) p.1) ◽  
pp. 186-187
Author(s):  
V. M. Shcherbakova
Keyword(s):  
Alcohol Intoxication ◽  
Kidney Tissue ◽  
Tissue Structure ◽  
Albino Rats ◽  
Acute Alcohol Intoxication ◽  
Optical Level ◽  
Rat Kidneys

The paper presents the results of a research of the kidneys of experimental rat kidneys at the light-optical level in acute alcohol intoxication. Prospects of further research in this field have been determined.

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