Clinical case of a child with a hereditary vitamin D dependent rickets type 1a, complicated by rachitic lung and oxygen dependence

2019 ◽  
Author(s):  
Nina Polyakova ◽  
Victoria Kakaulina ◽  
Vera Zarubina ◽  
Tatiana Nagornova ◽  
Elena Petraykina ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Case

scholarly journals Problems in differential diagnosis of secondary hyperparathyroidism

2021 ◽  
Vol 38 (1) ◽  
pp. 161-167
Author(s):  
S. G. Shulkina ◽  
D. O. Sirin ◽  
E. N. Smirnova ◽  
V. G. Zhelobov ◽  
N. Yu. Kolomeets ◽  
...  
Keyword(s):  
Vitamin D ◽  
Differential Diagnosis ◽  
Kidney Disease ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Clinical Case ◽  
Kidney Diseases ◽  
Active Form ◽  
Renal Tubules ◽  
Vitamin D Metabolism

Hyperparathyroidism is an endocrine disease characterized by excessive production of parathyroid hormone in the main cells of the parathyroid glands. Depending on the cause of this disease, there are primary, secondary (SHPT) and tertiary hyperparathyroidism. The most common causes of SHPT are vitamin D deficiency and chronic kidney disease (CKD). Vitamin D is converted to its active form by hydroxylation in the renal tubules. Developmental abnormalities and chronic kidney diseases lead to atrophy of the tubular epithelial cells that causes a violation of vitamin D metabolism and the development of SHPT, which in turn are accompanied by a violation of calcium-phosphorus metabolism and a syndrome of musculoskeletal disorders. This article presents an analysis of a clinical case of a patient diagnosed secondary hyperparathyroidism against the background of vitamin D deficiency combined with polycystic kidney disease. This clinical case reflects the complexity of the differential diagnosis of the disease and the tactics of patient's management.

scholarly journals The clinical case of a patient with syndrome of the falls

2021 ◽  
pp. 350-356
Author(s):  
V. I. Moroz ◽  
A. V. Naumov ◽  
N. O. Khovasova
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Carotid Artery ◽  
Physical Examination ◽  
Comprehensive Geriatric Assessment ◽  
Clinical Case ◽  
Geriatric Syndromes ◽  
Peripheral Polyneuropathy ◽  
Risk Factors For Falls ◽  
Causes And Risk Factors

This case shows a patient with a fall syndrome, which resulted in a severe rib fracture. The patient was thoroughly examined to identify the probable causes and risk factors for falls. The results of physical examination, comprehensive geriatric assessment and additional research methods revealed such geriatric syndromes as frailty, falls syndrome, vitamin D deficiency, peripheral polyneuropathy, and carotid artery stenosis. Thus, as a result of the examination, 7 risk factors for falls were identified in the patient, which turned out to be fully or partially modifiable.

scholarly journals Score twice before you cut once: a clinical case of reconstructive bariatric surgery after obesity surgery in a patient with postoperative hypothyroidism and hypoparathyroidism

2021 ◽  
Vol 12 (3) ◽  
pp. 92-97
Author(s):  
N. I. Volkova ◽  
Yu. S. Degtyareva ◽  
M. A. Burikov
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Vitamin D ◽  
Small Intestine ◽  
Clinical Case ◽  
Clinical Observation ◽  
Reverse Inclusion ◽  
Postoperative Hypoparathyroidism ◽  
History Of

Hundreds of thousands of bariatric surgeries are performed worldwide every year. Th ey have long been proven to be safe and eff ective in treating obesity and type 2 diabetes. Along with an unconditional positive eff ect, these interventions, especially shunting ones, are characterized by specifi c complications. In the absence of proper correction, they can become fatal for patients. One of these complications is malabsorption leading to a defi ciency of vitamins and microelements, which in most cases, is amenable to timely correction in the postoperative period. However, there are situations when it is not possible to carry out an eff ective correction and it becomes necessary to perform reconstructive interventions with the reverse inclusion of the small intestine in the digestion, which is associated with great diffi culties. Th e authors demonstrated this situation in the description of clinical observation of a patient with postoperative hypothyroidism and history of postoperative hypoparathyroidism, who underwent bariatric surgery. Impaired absorption of drugs (L-thyroxine, calcium, and vitamin D), and therefore, uncompensated hypothyroidism and hypocalcemia was an indication for reconstructive surgery.

scholarly journals A modern perspective of antiepileptic drugs effect on Vitamin D rate (reference data and clinical case)

2020 ◽  
Vol 10 (4) ◽  
pp. 193-197
Author(s):  
V.V. Povoroznyuk ◽  
Н.S. Dubetska ◽  
N.V. Zaverukha
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Antiepileptic Drugs ◽  
Sodium Valproate ◽  
Clinical Case ◽  
Young Patients ◽  
Systemic Review ◽  
Mineral Density ◽  
Vitamin D Metabolism ◽  
Patients With Epilepsy

This article presents a clinical case of the antiepileptic drug effect on the Vitamin D rate (namely, the patient has been taking Sodium Valproate for a long time) and new data from the foreign publications on this problem. It is known that there is a list of drugs that adversely affect the Vitamin D metabolism. In particular, the drugs reducing the Vitamin D absorption include drugs for the treatment of epilepsy. Antiepileptic drugs are drugs of va­rious origins that are used to prevent or reduce seizures, their corresponding conditions (loss or impairment of consciousness, behavioral and autonomic disorders, etc.), which are observed with recurrent seizures of various forms of epilepsy. The widespread use of these drugs in medical practice requires a detailed study of possible side effects of these drugs and their timely correction, as foreign sources indicate that antiepileptic drugs increase Vitamin D deficiency and worsen the symptoms of proximal myopathy, requiring mandatory medical correction; patients with epilepsy are deficient in vitamin D; сhronic Valproate therapy is associated with lower bone mineral density in young patients with epilepsy. This clinical case showed how a long-term use of Sodium Valproate led to the development of secondary systemic osteoporosis and Vitamin D deficiency, as evidenced by the results of laboratory and instrumental studies, and the discontinued antiepileptic drugs along with Vitamin D supplementation improved the general health of the patient and Vitamin D blood rates. Based on the systemic review and our own observations, it has been conclu­ded that epilepsy patients taking antiepileptic drugs should be gi­ven Vitamin D supplements to prevent the development of osteoporosis and Vitamin D deficiency.

An Unusual Ulcer

2018 ◽  
Vol 17 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Salvino Bilancini ◽  
Giulia D’amati ◽  
Bruna Cerbelli ◽  
Massimo Lucchi
Keyword(s):  
Vitamin D ◽  
Clinical Case ◽  
Radioiodine Therapy ◽  
Local Therapy ◽  
Computed Tomography Scan ◽  
Drug Induced ◽  
Blood Calcium ◽  
Venous Diseases ◽  
Painful Ulcer ◽  
Tomography Scan

This clinical case describes a 78-year-old female patient who underwent total thyroidectomy and parathyroidectomy due to thyroid cancer; surgery was followed by radioiodine therapy. The patient was treated with 20 µg of teriparatide once a day for 7 years and consistently showed above normal blood calcium levels. In addition, following the operation, the patient began taking 50 000 units of vitamin D orally every month and 1 g of calcium per os a day. A painful eschar had appeared on the front of her left leg 3 months before; it had developed into a deep, painful ulcer. The patient did not present arterial or venous diseases. Arterial hypertension was effectively managed with 5 mg of ramipril per day, renal function was normal, and the patient was not suffering from diabetes. A computed tomography scan gave evidence of extensive dermo-hypodermitis calcification in the ulcer area. A biopsy was performed and the histological examination revealed calciphylaxis. The patient was treated by suspending teriparatide, which actually had been suspended months before, and replacing it with bisphosphonate; suspension of calcium and vitamin D and the oral administration of 250 units of sulodexide every 12 hours. Local therapy was adapted according to the advancement of the ulcer’s stages. This case represents one of non-uremic calciphylaxis determined by an overly lengthy administration of a parathyroid hormone that caused drug-induced hyperthyroidism over a long period of time. A revision of the worldwide literature on the topic was carried out and an etiopathogenetic hypothesis concerning the clinical case is put forward.

scholarly journals CLINICAL CASE OF TERIPARATIDE USE FOR THE TREATMENT OF POSTOPERATIVE HYPOPARATHYROIDISM WITH UNCONTROLLED HYPOCALCEMIA COMBINED WITH SEVERE OSTEOPOROSIS

2016 ◽  
Vol 19 (3) ◽  
pp. 37-40 ◽  
Author(s):  
T A Grebennikova ◽  
I I Larina ◽  
Zh E Belaya ◽  
L Y Rozhinskaya
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Surgical Procedures ◽  
Clinical Case ◽  
Standard Treatment ◽  
Clinical Presentation ◽  
Severe Osteoporosis ◽  
Oral Calcium ◽  
Postoperative Hypoparathyroidism ◽  
Severe Clinical Presentation

The development of postsurgical hypoparathyroidism is the most frequent complication of thyroidectomy and radical surgical procedures on the neck. Hypoparathyroidism is a disorder characterized by hypocalcemia, parathyroid hormone (PTH) deficiency, and abnormal bone remodeling. Standard treatment of hypoparathyroidism consists of oral calcium and active forms of vitamin D. However, some patients fail to achieve the normalization of calcium levels with this therapy. We present a clinical case of postsurgical hypoparathyroidism with severe clinical presentation of hypocalcaemia treated with recombinant human PTH 1-34 - teriparatide.

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