scholarly journals Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure

2010 ◽  
Vol 163 (4) ◽  
pp. 671-680 ◽  
Author(s):  
Masanori Shimodaira ◽  
Tomohiro Nakayama ◽  
Naoyuki Sato ◽  
Noriko Aoi ◽  
Mikano Sato ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Ventricular Hypertrophy ◽  
Male Subject ◽  
Case Control Study ◽  
Recessive Model ◽  
Left Ventricular ◽  
Aldosterone Level ◽  
Ventricular Structure ◽  
Hormonal Steroids ◽  
Control Study

BackgroundHSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by affecting the aldosterone level.MethodsWe performed a haplotype- and diplotype-based case–control study to investigate the association between the HSD3B gene variations and essential hypertension (EH), aldosterone level, and left ventricular hypertrophy (LVH). A total of 275 EH patients and 286 controls were genotyped for four SNPs of the HSD3B1 gene (rs3765945, rs3088283, rs6203, and rs1047303) and for two SNPs of the HSD3B2 gene (rs2854964 and rs1819698). Aldosterone and LVH were investigated in 240 and 110 subjects respectively.ResultsSignificant differences were noted for the total and the male subject groups for the recessive model (CC versus TC+TT) of rs6203 between the controls and EH patients (P=0.030 and P=0.008 respectively). The frequency of the T-C haplotype established by rs3088283-rs1047303 was significantly higher for EH patients compared with the controls (P=0.014). Even though the polymorphism of HSB3B1 was not associated with LVH, the diplotype established by rs3088283-rs1047303 in the total subject group, along with the systolic BP, diastolic BP, and aldosterone level were significantly higher for those subjects who had the T-C haplotype versus those who did not (P=0.025, P=0.014, and P=0.006 respectively).Conclusionrs6203 and rs1047303 in the HSD3B1 gene are useful genetic markers for EH, while polymorphisms of HSD3B1 are associated with the BP and aldosterone level.

scholarly journals Association between insulin resistance and left ventricular hypertrophy in asymptomatic, Black, sub-Saharan African, hypertensive patients: a case–control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bernard Kianu Phanzu ◽  
Aliocha Nkodila Natuhoyila ◽  
Eleuthère Kintoki Vita ◽  
Jean-René M’Buyamba Kabangu ◽  
Benjamin Longo-Mbenza
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Independent Variables ◽  
Sub Saharan ◽  
Control Study

Abstract Background Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH). We described the associations between obesity, fasting insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), and LVH in Black patients with essential hypertension. Methods A case–control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, glucose metabolism and lipid disorder parameters, and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and independent variables, the effects of potential confounders were studied through the use of multiple linear regression and in conditional logistic regression in multivariate analyses. The coefficients of determination (R2), adjusted odds ratios (aORs), and their 95% confidence intervals (95% CIs) were calculated to determine associations between LVH and the independent variables. Results Eighty-eight LVH cases (52 men) were compared against 132 controls (81 men). Variation in left ventricular mass (LVM) could be predicted by the following variables: age (19%), duration of hypertension (31.3%), body mass index (BMI, 44.4%), waist circumference (WC, 42.5%), glycemia (20%), insulinemia (44.8%), and HOMA-IR (43.7%). Hypertension duration, BMI, insulinemia, and HOMA-IR explained 68.3% of LVM variability in the multiple linear regression analysis. In the logistic regression model, obesity increased the risk of LVH by threefold [aOR 2.8; 95% CI (1.06–7.4); p = 0.038], and IR increased the risk of LVH by eightfold [aOR 8.4; 95 (3.7–15.7); p < 0.001]. Conclusion Obesity and IR appear to be the primary predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized, with particular attention paid to obesity and IR. A prospective population-based study of Black sub-Saharan individuals that includes the use of serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role played by IR in Black sub-Saharan individuals with hypertension.

scholarly journals Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case–control study

BMJ Open ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. e010282 ◽  
Author(s):  
Ehsan Bahramali ◽  
Mona Rajabi ◽  
Javad Jamshidi ◽  
Seyyed Mohammad Mousavi ◽  
Mehrdad Zarghami ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Diastolic Heart Failure ◽  
Case Control ◽  
Left Ventricular ◽  
Ace Gene ◽  
Control Study

scholarly journals Association between insulin resistance and left ventricular hypertrophy in sub-saharan hypertensive black patients with preserved ejection fraction: A case control study

2020 ◽  
Author(s):  
Bernard KIANU PHANZU ◽  
Nkodila Natuhoyila Aliocha ◽  
Kintoki Vita Eleuthère ◽  
M’Buyamba Kabangu Jean-René ◽  
Longo-Mbenza Benjamin
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Independent Variables ◽  
Black Patients ◽  
Sub Saharan ◽  
Control Study

Abstract Background:Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH).We described the associations between parameters of obesity, fasting insulinemia, HOMAIR with LVH in black patients with essential hypertension.Materials and Methods:A case-control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationship between obesity indices, physical inactivity, parameters of glucose metabolisme and lipid disorders and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analysis, respectively. When differences were observed between LVH and the independent variables, the effect of potential confounders was studied by adjustment in multiple linear regression and in conditional logistic regression in multivariate analysis. The coefficients of determinations (R2), the adjusted ORs and their 95% CI were calculated to determine the association between the LVH and the independent variablesResults:Eighty-eight cases (52 men) were compared to 132 controls (81 men). Nineteen percent of left ventricular mass (LVM) variation (19%) was predicted by age, 31.3% by the duration of hypertension, 44.4% by BMI, 42.5% by WC, 20% by glycemia, 44.8% by insulinemia and 43.7% by HOMAIR. In multiple linear regression analysis, duration of hypertension, Body Mass Index (BMI), insulinemia and HOMAIR explained 68.3% of the variability in the increase in LVM. In the logisitic model obesity multiplied the risk of LVH by 3 (aOR: 2.8, 95% CI (1.06-7.4), p = 0.038), IR by 8 (aOR: 8.4, 95: (3.7-15.7), p <0.001).Conclusion:Obesity and IR appear to be the main predictors of LVH. The comprehensive management of cardiovascular risk factors should be emphasized with particular attention to obesity and insulin resistance. A prospective black sub-saharan population based study with serial imaging remain essential to better understand subclinical LV deterioration over time and to confirm the role of insulin resistance in black sub-saharan hypertensives.

scholarly journals Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi

2018 ◽  
Vol 1 (2) ◽  
pp. 67
Author(s):  
HERU SULASTOMO ◽  
FADLAN AKHYAR FAUZI ◽  
RATNA KUSUMAWATI
Keyword(s):  
Uric Acid ◽  
Left Ventricular Hypertrophy ◽  
Kidney Function ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Blood Perfusion ◽  
Left Ventricular ◽  
Chronic Hypertension ◽  
The Subject ◽  
Control Study

Introduction: Chronic hypertension can cause complication such as left ventricular <br />hypertrophy (LVH).  LVH can lead renal artery vasoconstriction, impaire blood perfusion <br />to glomerulus and change glomerulus filtration coeficient. The aim of this study was to<br />compare kidney function between hypertensive patient with LVH and without LVH<br />Methods: This was a case control study that conducted at Dr. Moewardi General<br />Hospital Surakarta. All subjects has been diagnosed as hypertension more than 5 years.<br />The diagnosis of LVH was based on electrocardiography (ECG) result. Kidney function<br />was assessed based on serum ureum, creatinin, and uric acid  levels.<br />Results: The subject of this study was 26 hypertension patients with LVH and 13<br />hypertension patients without LVH. Serum ureum level in patients with LVH was higher<br />than hypertension patients without LVH(24.92 ± 7.99 Vs 32.33±9.91, p= 0.004). Serum<br />uric acid level in hypertension patients with LVH was higher compare to hypertension<br />patients without LVH as well (5.26 ± 1.15 Vs 6.98 ± 1.83, p= 0.029). Whereas serum<br />creatinine levels were not significantly different between two groups of subjects.  <br />Sulastomo et.al., Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi <br />Conclusion: : Serum ureum and uric acid levels in hypertensive subjects with LVH are<br />higher than subjects without LVH. There is no difference between serum creatinin level in<br />hypertensive subject with LVH and without LVH.<br /><br /><br />

scholarly journals Twenty-four hour urine aldosterone level predicts left ventricular hypertrophy in patients with primary aldosteronism and essential hypertension

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4145-P4145
Author(s):  
C.- S. Hung ◽  
Y. L. H. Yi-Lwun Ho ◽  
V. C. W. Vin-Cent Wu ◽  
S. C. C. Shih-Chieh Chueh ◽  
Y. H. L. Yen-Hung Lin ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Primary Aldosteronism ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Aldosterone Level
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