scholarly journals Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

2011 ◽  
Vol 164 (5) ◽  
pp. 849 ◽  
Author(s):  
Mariano J Taverna ◽  
María T Martínez-Larrad ◽  
Gustavo D Frechtel ◽  
Manuel Serrano-Ríos
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Population ◽  
Lipid Accumulation Product

scholarly journals Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

2011 ◽  
Vol 164 (4) ◽  
pp. 559-567 ◽  
Author(s):  
Mariano J Taverna ◽  
María T Martínez-Larrad ◽  
Gustavo D Frechtel ◽  
Manuel Serrano-Ríos
Keyword(s):  
Metabolic Syndrome ◽  
Diagnostic Accuracy ◽  
Lipid Accumulation ◽  
International Diabetes Federation ◽  
Healthy Population ◽  
Model Assessment ◽  
Characteristic Analysis ◽  
Lipid Accumulation Product ◽  
The Metabolic Syndrome ◽  
Males And Females

ObjectiveThe metabolic syndrome (MS) is a cluster of cardiometabolic factors, which predisposes to diabetes and cardiovascular disease (CVD). Early detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes. The aim of this study was to explore the ability of lipid accumulation product (LAP), compared with traditional measures of IR, to identify MS.DesignIn total, 768 Spanish adults were recruited. MS was assessed using the revised criteria of National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) and International Diabetes Federation (IDF). Measures of IR such as homeostasis model assessment of IR and LAP, an index of lipid accumulation based on a combination of waist circumference and serum triglycerides, were calculated. Receiver operating characteristic analysis was performed in order to detect the parameter with the best predictive capability for MS.ResultsThe prevalence of MS-NCEP/ATP III and MS-IDF was 15.1 and 20.5% for men respectively, and 15.4 and 17.5% for women. LAP showed the highest diagnostic accuracy for MS-NCEP/ATP III (area under the curve 0.91 and 0.90 among males and females) and MS-IDF (0.88 for both males and females). This was confirmed by internal validation using 20 000 bootstrap samples. Among males and females, different LAP cut-off values exhibited high sensitivity (78–85%) and specificity (78–85%) for MS-NCEP/ATP III and MS-IDF identification with elevated efficiency (proportion of positives and negatives classified correctly by the test=78–85%). When the sample was stratified according to decades of life, LAP exhibited a slightly lower performance among women than men, especially for MS-IDF detection.ConclusionsIn non-diabetic adults LAP has a strong and reliable diagnostic accuracy for MS-IDF and, especially, MS-NCEP/ATP III among females and, in particular, among males from Spain.

scholarly journals Identification of lipid accumulation product (LAP) as a marker of metabolic syndrome: a study in healthy population of MMU

2021 ◽  
Vol 12 (2) ◽  
pp. 958-966
Author(s):  
Bhumija Sharma ◽  
Suvarna Prasad ◽  
Sunita Manhas ◽  
Bhawani Shankar Modi ◽  
PriyankaTangri
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Disease Risk ◽  
Roc Curves ◽  
Public Health Issue ◽  
Healthy Population ◽  
Lipid Accumulation Product ◽  
Related Disease ◽  
Apparently Healthy

Metabolic syndrome (MetS), is a collection of lipid and non-lipid cardiac related disease risk factors, is an important public health issue because of its higher prevalence with development of diabetes mellitus and cardiovascular diseases. Henry Kahn anticipated lipid accumulation product (LAP), as a novel marker of central lipid accumulation, to predict the risk of MetS. This study was conducted in Department of Biochemistry of MMIMSR, Ambala, Haryana. In the current study, we are researching over a new diagnostic tool for diagnosing MetS by LAP use. MetS is diagnosed by National Cholesterol Education Program Adults treatment panel III (NCEPATP III) and then compared with LAP to find its efficacy over other variables. 200 volunteers were enrolled in this study, their biochemical parameters were estimated and anthropometric measurements were taken. MetS was diagnosed in apparently healthy subjects. LAP was calculated by Henry Kahn formula and required statistical tools were applied to analyse results. The parameters of MetS positive cases were compared with LAP and its validity was tested statistically. 56 (28%) out of 200 subjects were positive for MetS. More females (30) than males (26) were diagnosed positive for MetS. LAP values were found to be higher in MetS cases, its efficacy was confirmed by ROC curves. MetS was diagnosed in volunteers who were considering themselves as healthy. Raised LAP and LAP2 were found, in MetS positive subjects than MetS negative. Relation of LAP and MetS came to be strong. Further, researches in this area are definitely recommended.

Value of lipid accumulation product for the assessment of metabolic syndrome in women with polycystic ovary syndrome

2013 ◽  
Author(s):  
Antic Ivana Bozic ◽  
Jelica Bjekic-Macut ◽  
Dimitrios Panidis ◽  
Danijela Vojnovic Milutinovic ◽  
Biljana Kastratovic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Lipid Accumulation ◽  
Polycystic Ovary ◽  
Lipid Accumulation Product ◽  
Ovary Syndrome

Hypertensive Waist and Lipid Accumulation Product as Predictors of Metabolic Syndrome

2018 ◽  
Vol 16 (10) ◽  
pp. 505-506
Author(s):  
Cristina Nita ◽  
Adriana Rusu ◽  
Nicolae Hancu ◽  
Gabriela Roman ◽  
Cornelia Bala
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Lipid Accumulation Product

scholarly journals Lipid accumulation product is a reliable indicator for identifying metabolic syndrome: the China Multi-Ethnic Cohort (CMEC) Study

QJM ◽  
2020 ◽  
Author(s):  
X Zhang ◽  
F Hong ◽  
L Liu ◽  
F Nie ◽  
L Du ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Roc Curve ◽  
Lipid Accumulation ◽  
Operating Characteristic ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sensitivity Analyses ◽  
Lipid Accumulation Product ◽  
Cross Sectional ◽  
Obesity Indices

Abstract Background Previous studies have shown that lipid accumulation product (LAP) was associated with the risk of cardiometabolic disease. It is not clear whether LAP could be used as a marker to identify metabolic syndrome (MetS) among Chinese ethnic groups. Aim: To assess the reliability of LAP as a maker to identify MetS among Dong adults. Design: Population-based cross-sectional study. Method We included 6494 Dong individuals (1403 patients) aged 30–79 years from southwest China. MetS was established by Chinese Diabetes Society. Logistic regression model was utilized to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic (ROC) curve was utilized to calculate area under the ROC curve (AUC) and 95% CIs to obtain the identification ability for MetS. Results The risk of MetS was increased with per 5 units increase of LAP (OR 1.37 [95% CI, 1.34–1.39]). Similar results were found in subgroup analyses and sensitivity analyses. Clustered metabolic risk associated with per 5 units increase of LAP was observed for people with 1 (OR 1.59 [95% CI, 1.53–1.65]), 2 (2.15 [2.06–2.24]), 3 (2.59 [2.48–2.71]), 4 (2.81 [2.69–2.95]) and 5 (3.03 [2.87–3.21]) MetS components. LAP presented higher AUC (0.915 [95% CI, 0.907–0.923]) than other included obesity indices (P < 0.05). Conclusion These data support evidence that LAP was related to the risk of MetS, had a high AUC and could be a reliable index for identifying MetS patients among Dong adults in Chinese.

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