scholarly journals Identification of lipid accumulation product (LAP) as a marker of metabolic syndrome: a study in healthy population of MMU

2021 ◽  
Vol 12 (2) ◽  
pp. 958-966
Author(s):  
Bhumija Sharma ◽  
Suvarna Prasad ◽  
Sunita Manhas ◽  
Bhawani Shankar Modi ◽  
PriyankaTangri
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Disease Risk ◽  
Roc Curves ◽  
Public Health Issue ◽  
Healthy Population ◽  
Lipid Accumulation Product ◽  
Related Disease ◽  
Apparently Healthy

Metabolic syndrome (MetS), is a collection of lipid and non-lipid cardiac related disease risk factors, is an important public health issue because of its higher prevalence with development of diabetes mellitus and cardiovascular diseases. Henry Kahn anticipated lipid accumulation product (LAP), as a novel marker of central lipid accumulation, to predict the risk of MetS. This study was conducted in Department of Biochemistry of MMIMSR, Ambala, Haryana. In the current study, we are researching over a new diagnostic tool for diagnosing MetS by LAP use. MetS is diagnosed by National Cholesterol Education Program Adults treatment panel III (NCEPATP III) and then compared with LAP to find its efficacy over other variables. 200 volunteers were enrolled in this study, their biochemical parameters were estimated and anthropometric measurements were taken. MetS was diagnosed in apparently healthy subjects. LAP was calculated by Henry Kahn formula and required statistical tools were applied to analyse results. The parameters of MetS positive cases were compared with LAP and its validity was tested statistically. 56 (28%) out of 200 subjects were positive for MetS. More females (30) than males (26) were diagnosed positive for MetS. LAP values were found to be higher in MetS cases, its efficacy was confirmed by ROC curves. MetS was diagnosed in volunteers who were considering themselves as healthy. Raised LAP and LAP2 were found, in MetS positive subjects than MetS negative. Relation of LAP and MetS came to be strong. Further, researches in this area are definitely recommended.

scholarly journals Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

2011 ◽  
Vol 164 (4) ◽  
pp. 559-567 ◽  
Author(s):  
Mariano J Taverna ◽  
María T Martínez-Larrad ◽  
Gustavo D Frechtel ◽  
Manuel Serrano-Ríos
Keyword(s):  
Metabolic Syndrome ◽  
Diagnostic Accuracy ◽  
Lipid Accumulation ◽  
International Diabetes Federation ◽  
Healthy Population ◽  
Model Assessment ◽  
Characteristic Analysis ◽  
Lipid Accumulation Product ◽  
The Metabolic Syndrome ◽  
Males And Females

ObjectiveThe metabolic syndrome (MS) is a cluster of cardiometabolic factors, which predisposes to diabetes and cardiovascular disease (CVD). Early detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes. The aim of this study was to explore the ability of lipid accumulation product (LAP), compared with traditional measures of IR, to identify MS.DesignIn total, 768 Spanish adults were recruited. MS was assessed using the revised criteria of National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) and International Diabetes Federation (IDF). Measures of IR such as homeostasis model assessment of IR and LAP, an index of lipid accumulation based on a combination of waist circumference and serum triglycerides, were calculated. Receiver operating characteristic analysis was performed in order to detect the parameter with the best predictive capability for MS.ResultsThe prevalence of MS-NCEP/ATP III and MS-IDF was 15.1 and 20.5% for men respectively, and 15.4 and 17.5% for women. LAP showed the highest diagnostic accuracy for MS-NCEP/ATP III (area under the curve 0.91 and 0.90 among males and females) and MS-IDF (0.88 for both males and females). This was confirmed by internal validation using 20 000 bootstrap samples. Among males and females, different LAP cut-off values exhibited high sensitivity (78–85%) and specificity (78–85%) for MS-NCEP/ATP III and MS-IDF identification with elevated efficiency (proportion of positives and negatives classified correctly by the test=78–85%). When the sample was stratified according to decades of life, LAP exhibited a slightly lower performance among women than men, especially for MS-IDF detection.ConclusionsIn non-diabetic adults LAP has a strong and reliable diagnostic accuracy for MS-IDF and, especially, MS-NCEP/ATP III among females and, in particular, among males from Spain.

scholarly journals Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population

2011 ◽  
Vol 164 (5) ◽  
pp. 849 ◽  
Author(s):  
Mariano J Taverna ◽  
María T Martínez-Larrad ◽  
Gustavo D Frechtel ◽  
Manuel Serrano-Ríos
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Population ◽  
Lipid Accumulation Product

scholarly journals Range of values for lipid accumulation product (LAP) in healthy residents of the European north of Russia

2020 ◽  
Vol 17 (2) ◽  
pp. 179-186
Author(s):  
Anastasiya M. Kaneva ◽  
Natalya N. Potolitsyna ◽  
Evgeny R. Bojko
Keyword(s):  
Sex Differences ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Metabolic Disorders ◽  
Visceral Obesity ◽  
Lipid Accumulation Product ◽  
Major Health Problem ◽  
Wide Range ◽  
Variation Range ◽  
Apparently Healthy

BACKGROUND: Obesity is a major health problem in modern society and its prevalence throughout the world has reached the epidemic level. The unfavorable outcomes of obesity are associated with a high risk of numerous diseases due to metabolic disorders. Finding of diagnostic criteria for early detection of obesity is a priority in biomedical research. Therefore, of particular interest is the new visceral obesity marker lipid accumulation product (LAP). Meanwhile, to date, the reference values for LAP are not defined, and data on sex- and age-related changes are contradictory. AIMS: The aim of this study was to determine the variation range, sex and age differences in LAP values in healthy subjects. MATERIALS AND METHODS: The study was conducted on apparently healthy subjects (455 men and 286 women) aged 2059 years selected at routine examinations at the base of the central clinic in Arkhangelsk. Examination of subjects consisted of physical examination with measurement of anthropometric and clinical parameters, filling out a questionnaire, and evaluation of serum lipid levels. RESULTS: The LAP values in the subjects varied in a wide range (0.5156.5 cmmmol/l in men; 0.4 to 116.2 cmmmol/l in women), but at the same they in 75% of the participants did not exceed 30 cmmmol/l. Sex differences in LAP with the prevalence of values in men were observed in the age groups up to 40 years old, later they disappeared. LAP in men and women increased with age, but these changes were unequal. The LAP values increased to reach a plateau in men up to 30 years of age and in women up to 40 years of age. CONCLUSIONS: LAP is a combined index that simultaneously reflects distribution of adipose tissue and changes in blood lipids, and is considered a marker of obesity associated with the risk of metabolic disorders. This study was the first to determine the variation range, sex differences and age dynamics for LAP in the apparently healthy subjects.

scholarly journals Lipid Accumulation Product: An Effective Obesity Index to Predict Metabolic Syndrome

2022 ◽  
Vol 40 (1) ◽  
pp. 5-9
Author(s):  
Mariya Tabassum ◽  
Miliva Mozaffor ◽  
Md Matiur Rahman ◽  
Reaz Mahmud Huda
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Predictive Value ◽  
Significant Risk ◽  
Area Under The Curve ◽  
Lipid Accumulation Product ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Obesity Index ◽  
Apparently Healthy

Background: Obesity is a significant risk factor in the development of metabolic syndrome (MetS). Lipid Accumulation Product (LAP) is an obesity index and has been proposed to be a predictor of metabolic syndrome. The present study aims to see the effectiveness of Lipid Accumulation Product as an obesity index to predict metabolic syndrome in a Bangladeshi population. Methods: This cross-sectional study was conducted in Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between March 2016 and February 2017. A total of 200 apparently healthy subjects (127 men and 73 women) were selected for the study, attending out-patient-departments of the same institution. Anthropometric measurements were recorded, which included their height, weight, waist circumference (WC) and body mass index (BMI). Overnight fasting blood samples were collected to estimate fasting serum glucose and lipid profile. Then LAP was calculated and evaluated as a tool in prediction of MetS in the study subjects. Receiver operating characteristic (ROC) curves were plotted to assess the performance of LAP in MetS prediction by gender. The power of MetS prediction was quantified by the area under the curve (AUC) with 95% confidence intervals. Results: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) of LAP in predicting MetS were 70.45%, 78.57%, 72.09% and 77.19% in male study subjects and 20.45%, 96.43%, 81.82% and 60.67% in female subjects respectively. ROC curve analysis showed that the optimal cutoff value of LAP in male study subjects was 40.72, while area under the curve was 0.92; in female study subjects, the values were 51.69 and 0.91 respectively (P<0.001). Conclusion: Lipid Accumulation Product was found simple, accessible and effective obesity index to predict metabolic syndrome in apparently healthy adults. J Bangladesh Coll Phys Surg 2022; 40: 5-9

Value of lipid accumulation product for the assessment of metabolic syndrome in women with polycystic ovary syndrome

2013 ◽  
Author(s):  
Antic Ivana Bozic ◽  
Jelica Bjekic-Macut ◽  
Dimitrios Panidis ◽  
Danijela Vojnovic Milutinovic ◽  
Biljana Kastratovic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Lipid Accumulation ◽  
Polycystic Ovary ◽  
Lipid Accumulation Product ◽  
Ovary Syndrome

Liver stiffness values in apparently healthy subjects: Influence of gender and metabolic syndrome

2008 ◽  
Vol 48 (4) ◽  
pp. 606-613 ◽  
Author(s):  
Dominique Roulot ◽  
Sébastien Czernichow ◽  
Hervé Le Clésiau ◽  
Jean-Luc Costes ◽  
Anne-Claire Vergnaud ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Healthy Subjects ◽  
Liver Stiffness ◽  
Apparently Healthy

A novel indicator, relative children’s lipid accumulation product (RCLAP) for metabolic syndrome

2020 ◽  
Author(s):  
Li Zhang ◽  
Zizhe Zhang ◽  
Bangxuan Wang ◽  
Yongting Yuan ◽  
Lili Sun ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Lipid Accumulation ◽  
Vigorous Physical Activity ◽  
Roc Curves ◽  
Chinese Children ◽  
Cluster Sampling ◽  
Activity Time ◽  
Lipid Accumulation Product ◽  
Increased Risk ◽  
Chinese Children And Adolescents

Abstract BackgroundThe children’s lipid accumulation product (CLAP) was associated with MS in Chinese children and adolescents. The study was to develop a more effective indicator, relative children’s lipid accumulation product （RCLAP）associated with MS reflect the density of lipid accumulation among Chinese children and adolescents. MethodsA stratified cluster sampling method was used to recruit 683 students aged 8-15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The t-test, chi-square test, logistic regression models were used to analyze the associations of SBMI, SWHtR, SlnCLAP, SRCLAP-H, SRCLAP-SH, RCLAP-W with MS. Receiver Operating Characteristic (ROC) curves was used to evaluate the predictive efficiency of above indexes for predicting MS. ResultsThe overall prevalence of MS was 4.8% (boys 6.6%, girls 2.8%). In girls, after adjusting for sedentary activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and RCLAP-W significantly increased risk of MS (OR(95%CI):15.79 (3.15-79.21), 3.73 (0.87-15.95), Null, 96.13 (11.11-831.97), 96.13 (11.11-831.97), 18.28 (4.24-78.87), respectively). In boys, after adjusting for ages and moderate-to-vigorous physical activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and SRCLAP-W significantly increased risk of MS (OR(95%CI): 37.43(11.67-120.10), 68.33(18.51-252.20), 105.86(21.99-509.68), 171.75(33.60-878.00), 133.18(27.65-641.39), 50.13(15.48-162.37, respectively). The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than these of BMI, WHtR, CLAP and RCLAP-W.ConclusionThe relative children，s lipid accumulation products（RCLAP-H and RCLAP-SH ) were more effective indicators for predicting MS than BMI, WHtR and CLAP in Chinese children and adolescents.

Sign in / Sign up

Export Citation Format

Share Document