Disruption of mesenchymal glucocorticoid signaling attenuates embryonic lung development and results in post natal lethality in mice

2013 ◽  
pp. 1-1
Author(s):  
Rowan Hardy ◽  
Aiqing Li ◽  
Shihani Stoner ◽  
Jan Tuckermann ◽  
Markus Seibel ◽  
...  
Keyword(s):  
Lung Development ◽  
Embryonic Lung ◽  
Glucocorticoid Signaling

scholarly journals Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy

2009 ◽  
Vol 124 (3) ◽  
pp. 590-597.e11 ◽  
Author(s):  
Hans Michael Haitchi ◽  
David J.P. Bassett ◽  
Fabio Bucchieri ◽  
Xiufeng Gao ◽  
Robert M. Powell ◽  
...  
Keyword(s):  
Lung Development ◽  
Embryonic Lung

scholarly journals Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling

2017 ◽  
Vol 1863 (12) ◽  
pp. 3226-3242 ◽  
Author(s):  
Musaddique Hussain ◽  
Chengyun Xu ◽  
Meiping Lu ◽  
Xiling Wu ◽  
Lanfang Tang ◽  
...  
Keyword(s):  
Lung Development ◽  
Airway Remodeling ◽  
Embryonic Lung ◽  
Asthmatic Airway

scholarly journals REGULATION OF MURINE EMBRYONIC LUNG DEVELOPMENT BY NPAS1 AND NPAS3

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Shutang Zhou ◽  
Lin Shan ◽  
Mary E. Sunday
Keyword(s):  
Lung Development ◽  
Embryonic Lung

Antisense oligodeoxynucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development

Development ◽  
1994 ◽  
Vol 120 (8) ◽  
pp. 2163-2173 ◽  
Author(s):  
P. Souza ◽  
L. Sedlackova ◽  
M. Kuliszewski ◽  
J. Wang ◽  
J. Liu ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Lung Development ◽  
Neutralizing Antibodies ◽  
Fetal Lung ◽  
Inhibitory Effect ◽  
Antisense Oligodeoxynucleotides ◽  
Dependent Manner ◽  
Rat Lung ◽  
Embryonic Lung ◽  
Concentration Dependent Manner

There is increasing evidence to suggest that platelet-derived growth factor (PDGF) or PDGF-like molecules play a role in fetal lung morphogenesis. Our previous studies demonstrated the presence of PDGF-AA and PDGF-BB homodimers in embryonic and fetal rat lung. To explore further the role for PDGF-BB in embryonic lung development, we conducted intervention studies using PDGF-B chain-specific antisense oligodeoxynucleotides in a simple embryonic rat lung explant system. Unmodified antisense PDGF-B oligodeoxynucleotides inhibited, in a concentration-dependent manner, DNA synthesis of embryonic lung. A maximal inhibition of 50% was observed. The inhibitory effect of antisense PDGF-B oligodeoxynucleotides on DNA synthesis was reversed by the addition of exogenous PDGF-BB but not PDGF-AA. Antisense treatment decreased PDGF-BB but not PDGF-AA protein content, as assessed by immunoblot analyses. Incubation of lung explants with PDGF-BB neutralizing antibodies also resulted in an inhibition of DNA synthesis. Morphometric analyses of antisense-treated cultures showed a significant reduction in lung size when compared to control cultures. The epithelial component of the embryonic lungs was specifically reduced, both in mass and DNA labelling index, by antisense treatment. The number of terminal buds of the lung explants was not significantly affected by antisense PDGF-B treatment. Scrambled PDGF-B oligodeoxynucleotides had no effect. These data suggest that PDGF-BB is involved in regulating growth, but not the degree of branching, of embryonic rat lung.

The role of oxygen tension in the regulation of embryonic lung development

2005 ◽  
Vol 40 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Toko Shinkai ◽  
Masato Shinkai ◽  
Martina A. Pirker ◽  
Sandra Montedonico ◽  
Prem Puri
Keyword(s):  
Oxygen Tension ◽  
Lung Development ◽  
Embryonic Lung

Constitutive Fgf10 deficiency leads to impaired embryonic lung development

Pneumologie ◽  
2015 ◽  
Vol 69 (07) ◽  
Author(s):  
F Yahya ◽  
CM Chao ◽  
S Bellusci
Keyword(s):  
Lung Development ◽  
Embryonic Lung
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