Mitochondrial mass and function is regulated by PI3K signaling in thyroid cancer cells

2013 ◽  
Author(s):  
K Alexander Iwen ◽  
Erich Schroder ◽  
Julia Resch ◽  
Ulrich Lindner ◽  
Peter Konig ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Pi3k Signaling ◽  
Mitochondrial Mass ◽  
And Function ◽  
Thyroid Cancer Cells

Impact of PI3K signaling on mitochondrial mass and function in thyroid cancer cells

2013 ◽  
Vol 121 (03) ◽  
Author(s):  
KA Iwen ◽  
E Schröder ◽  
J Resch ◽  
H Lehnert ◽  
N Perwitz ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Pi3k Signaling ◽  
Mitochondrial Mass ◽  
And Function ◽  
Thyroid Cancer Cells

scholarly journals CXC Chemokine Receptor 4 Expression and Function in Human Anaplastic Thyroid Cancer Cells

2003 ◽  
Vol 88 (1) ◽  
pp. 408-416 ◽  
Author(s):  
Jung Hwan Hwang ◽  
Jin Hee Hwang ◽  
Hyo Kyun Chung ◽  
Dong Wook Kim ◽  
Eun Suk Hwang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Anaplastic Thyroid Cancer ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
And Function ◽  
Chemokine Receptor 4 ◽  
Thyroid Cancer Cells

Anti-proliferative effects of evodiamine on human thyroid cancer cells

2014 ◽  
Author(s):  
Ying-Ray Lee ◽  
Chieh-Hsiang Lu ◽  
Yi-Sheng Chang ◽  
Yi-Wen Liu
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Human Thyroid ◽  
Thyroid Cancer Cells

scholarly journals Retraction: Overexpression of PCDH8 inhibits proliferation and invasion, and induces apoptosis in papillary thyroid cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4163-4163
Author(s):  
Laura Fisher
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Thyroid Cancer Cells ◽  
Proliferation And Invasion

Retraction of ‘Overexpression of PCDH8 inhibits proliferation and invasion, and induces apoptosis in papillary thyroid cancer cells’ by Liang Chang et al., RSC Adv., 2018, 8, 18030–18037, DOI: 10.1039/C8RA02291G.

scholarly journals Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3022
Author(s):  
Yukyung Hong ◽  
Jaehak Lee ◽  
Hyunjin Moon ◽  
Chang H. Ryu ◽  
Jungirl Seok ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Cancer Prognosis ◽  
Antibody Array ◽  
Dependent Manner ◽  
Normal Tissues ◽  
Cycle Arrest ◽  
Novel Biomarkers ◽  
Thyroid Cancer Cells

Although the treatment of thyroid cancer has improved, unnecessary surgeries are performed due to a lack of specific diagnostic and prognostic markers. Therefore, the identification of novel biomarkers should be considered in the diagnosis and treatment of thyroid cancer. In this study, antibody arrays were performed using tumor and adjacent normal tissues of patients with papillary thyroid cancer, and several potential biomarkers were identified. Among the candidate proteins chosen based on the antibody array data, mature NAG-1 exhibited increased expression in tumor tissues compared to adjacent normal tissues. In contrast, pro-NAG-1 expression increased in normal tissues, as assessed by western blot analysis. Furthermore, pro-NAG-1 expression was increased when the thyroid cancer cells were treated with phytochemicals and nonsteroidal anti-inflammatory drugs in a dose-dependent manner. In particular, quercetin highly induced the expression of pro-NAG-1 but not that of mature NAG-1, with enhanced anticancer activity, including apoptosis induction and cell cycle arrest. Examination of the NAG-1 promoter activity showed that p53, C/EBPα, or C/EBPδ played a role in quercetin-induced NAG-1 expression. Overall, our study indicated that NAG-1 may serve as a novel biomarker for thyroid cancer prognosis and may be used as a therapeutic target for thyroid cancers.

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