The diagnostic value of FNAB for early diagnosis of thyroid cancer: a Greek center experience

Objectives: This study aims to discover a potential cytokine biomarker for early diagnosis of thyroid cancer. Methods: We employed data mining of The Cancer Genome Atlas (TCGA) and experimentally elucidated its mechanistic contributions. The differential expression genes (DEGs) between thyroid cancer and health population were analyzed with TCGA online bioinformatic tools. The relative expression of Bone Morphogenetic Protein 8A (BMP8A) was determined by real-time PCR in ultrasonic diagnosed thyroid cancer both in vivo and in vitro. The serous BMP8A content was quantified with an ELISA kit. Protein levels of BMP8A, OCLN, ZEB1, EZH2 and β-Actin were analyzed by Western blot. Cell viability was measured by the MTT assay, and anchorage-independent growth was measured by the soft agar colony formation assay. Cell migrative and invasive capacities were interrogated with transwell chamber assays. Results: We identified aberrantly high expression of BMP8A in thyroid cancer, which was associated with unfavorable prognosis and tumor progression. The serous BMP8A was also significantly up-regulated in thyroid cancer patients. Ectopic over-expression of BMP8A remarkably stimulated cell viability and anchorage-independent growth. Meanwhile, the migrative and invasive capacities were greatly increased in response to BMP8A over-expression. Mechanistically, we characterized the positive correlation between BMP8A and TCF7L1, and forced expression of TCF7L1 induced BMP8A expression in TPC-1 cells. Conclusion: In summary, we have identified a novel biomarker for early diagnosis in addition to Ultrasound for thyroid cancer, which is subjected to TCF7L1 regulation.

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Radioiodide Treatment of Pulmonary Metastases of Differentiated Thyroid Cancer

Nuklearmedizin ◽

10.1055/s-0037-1620881 ◽

1979 ◽

Vol 18 (02) ◽

pp. 86-90 ◽

Cited By ~ 26

Author(s):

V. Zamrazil ◽

D. Pohunková ◽

S. Röhling ◽

J. Němec

Keyword(s):

Thyroid Cancer ◽

Bone Metastases ◽

Differentiated Thyroid Cancer ◽

Pulmonary Metastases ◽

Survival Rates ◽

Younger Patients ◽

131I Uptake ◽

Young Subjects ◽

Radioiodide Therapy ◽

Diagnosis Of Thyroid Cancer

Pulmonary metastases were found in 123 out of 840 patients with thyroid cancer between 1955-1977. 87 patients with pulmonary metastases of differentiated cancer were studied in detail, including an evaluation of prognostically important factors. In 66 of them, the induction of 131I uptake in metastases was attempted, in half of them successfully. Uptake was achieved more frequently in younger subjects, in papillary cancers and in patients with fine pulmonary metastases on chest films. Survival (not corrected for age) was evaluated 10 and 15 years following the diagnosis of thyroid cancer and was found to be 29,1 % and 12,2%, respectively. Significantly higher survival rates were seen in younger patients, in patients with the fine type of pulmonary metastases, in the absence of bone metastases and, particularly, in patients with induced 131I uptake in metastases. Papillary cancers were found to have higher survival rates in males and in young subjects only, in the whole group the survival rates were independent of either microscopic type or sex. It is believed that biologic behaviour of distant (pulmonary) metastases may be influenced by radioiodide therapy.

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Thy 3F and 3a malignancy rate, a multisite regional retrospective case series

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2018.0103 ◽

2018 ◽

Vol 100 (7) ◽

pp. 545-550 ◽

Cited By ~ 2

Author(s):

V Alexander ◽

J Rudd ◽

D Walker ◽

G Wong ◽

A Lunt ◽

...

Keyword(s):

Thyroid Cancer ◽

Royal College ◽

Case Series ◽

Thyroid Malignancy ◽

Retrospective Case ◽

Retrospective Case Series ◽

Indeterminate Nodules ◽

The Uk ◽

Diagnosis Of Thyroid Cancer ◽

Benign Thyroid

Introduction The aim of this study was to ascertain the incidence of thyroid cancer for patients categorised as Thy3, 3a or 3f across four tertiary thyroid multidisciplinary centres in the UK. Material and methods This is a retrospective case series examining patients who presented with a thyroid nodule and diagnosed as Thy3, 3a or 3f according to the Royal College of Pathologists modified British Thyroid Association and Royal College of Physicians Thy system. Results In total, 395 patients were included in this study. Of these, 136 turned out to have benign thyroid disease and 24 had micropapillary thyroid carcinomas. The overall rate of thyroid malignancy was 28.8%. For each subcategory, the rate of malignancy was Thy3 24.7.7%, Thy3a 30.4% and Thy3f 29.2. However, the incidence of thyroid malignancy varied considerably between the four centres (Thy 3f 18-54%). Discussion The diagnosis of thyroid cancer is evolving but detection for malignancy for indeterminate nodules remains below 50% for most centres around the world. In 2014, the British Thyroid Association subdivided the original Thy3 category into Thy3a and Thy3f and recommended a more conservative approach to management for Thy3a nodules. Despite this, only two centres yielded a higher conversion rate of malignancy in the new higher graded Thy3f group compared with Thy3a. Conclusion It is debateable whether the new ‘Thy3’ subcategories are more useful than the original. Local thyroid malignancy rates may also be more useful than national averages to inform treatment decisions.

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Ectopic Cushing syndrome secondary to metastatic medullary thyroid cancer in a child with multiple endocrine neoplasia syndrome type 2B: clues to early diagnosis of the paraneoplastic syndromes

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2013-0456 ◽

2014 ◽

Vol 27 (9-10) ◽

Cited By ~ 2

Author(s):

Kanakadurga Singer ◽

Nicholas Heiniger ◽

Inas Thomas ◽

Francis P. Worden ◽

Ram K. Menon ◽

...

Keyword(s):

Thyroid Cancer ◽

Early Diagnosis ◽

Multiple Endocrine Neoplasia ◽

Medullary Thyroid Cancer ◽

Cushing Syndrome ◽

Paraneoplastic Syndromes ◽

Syndrome Type ◽

Medullary Thyroid ◽

Endocrine Neoplasia ◽

Multiple Endocrine Neoplasia Syndrome

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Diagnosis of thyroid cancer using a TI-RADS-based computer-aided diagnosis system: a multicenter retrospective study

Clinical Imaging ◽

10.1016/j.clinimag.2020.12.012 ◽

2021 ◽

Author(s):

Zhuang Jin ◽

Yaqiong Zhu ◽

Shijie Zhang ◽

Fang Xie ◽

Mingbo Zhang ◽

...

Keyword(s):

Thyroid Cancer ◽

Retrospective Study ◽

Computer Aided Diagnosis ◽

Diagnosis System ◽

System A ◽

Computer Aided ◽

Diagnosis Of Thyroid Cancer ◽

Aided Diagnosis

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Multi-Parameter Magnetic Resonance Imaging Fusion Technology Assists in Bone Diagnosis and Rehabilitation of Prostate Cancer

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3700 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1753-1760

Author(s):

Yuzhu Jia ◽

Yibo Ying ◽

Jianju Feng

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Detection Rate ◽

Diagnostic Technique ◽

Diagnostic Value ◽

Resonance Imaging ◽

High Risk Factors ◽

Transrectal Biopsy

Multi-parameter magnetic resonance imaging has been widely used in the diagnosis and evaluation of prostate cancer, and has important guiding significance for clinical diagnosis of prostate cancer and their treatment. This article studies the value of transrectal multiparametric ultrasound (mpUSS) in the diagnosis of clinically meaningful prostate cancer. 102 patients with high risk factors for prostate cancer were examined by mpUSS and mpMRI. The transrectal biopsy (SB) results of the prostate system were regarded as the excellent standard, and the diagnostic value of mpUSS, mpMRl and mpUSS combined with mpMRl examination for clinically meaningful prostate cancer was analyzed. The results showed that 58 of the 102 patients with SB were diagnosed with prostate cancer. Among them, 43 cases were detected by mpUSS, 50 cases were detected by mpMRl, 42 cases were detected by mpUSS combined with mpMRI (series), and 56 cases were detected by mpUSS combined with mpMRl (parallel). Grouped by Gleason score, the detection rate of mpUSS for clinically significant prostate cancer was 83.74%, and the detection rate of mpMRl was 93.5%. The comparison between the two was not statistically significant (P > 0.05), but when the two inspection methods were combined. The detection rate was 97.8%, which was significantly higher than the two inspection methods alone. Therefore, we conclude that mpUSS can be used as an imaging test for the diagnosis of prostate cancer. In addition, mpUSS has a high application value in the diagnosis of prostate cancer. The detection rate of mpUSS combined with mpMRl examination for clinically meaningful prostate cancer is significantly higher than that of mpMRl examination alone, which can be used as a diagnostic technique for early diagnosis of meaningful prostate cancer and can be used as a guide clinicians’ early diagnosis and treatment of meaningful prostate cancer.

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