The role of plant natural products in diabetes drug discovery and development: A report with focus on Nigerian biodiversity

2016 ◽  
Author(s):  
Abdulfatai Temitope Ajiboye ◽  
Olayinka Taiwo Asekun ◽  
Oluwole B. Familoni
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Drug Discovery And Development ◽  
Plant Natural Products ◽  
Diabetes Drug

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

2020 ◽  
Author(s):  
Gina Porras ◽  
François Chassagne ◽  
James T. Lyles ◽  
Lewis Marquez ◽  
Micah Dettweiler ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Plant Natural Products ◽  
Antibiotic Drug

Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data

2020 ◽  
Vol 107 (4) ◽  
pp. 796-805 ◽  
Author(s):  
Daniela J. Conrado ◽  
Sridhar Duvvuri ◽  
Hugo Geerts ◽  
Jackson Burton ◽  
Carla Biesdorf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Open Data ◽  
Drug Discovery And Development ◽  
Modeling Simulation

The Role of Aromatase Enzyme in Hormone Related Diseases and Plant-Based Aromatase Inhibitors as Therapeutic Regimens

2021 ◽  
Vol 21 ◽  
Author(s):  
Kevser Taban Akça ◽  
Murside Ayşe Demirel ◽  
Ipek Süntar
Keyword(s):  
Natural Products ◽  
Aromatase Inhibitors ◽  
Inhibitory Activity ◽  
Chemical Compounds ◽  
Synthesis Methods ◽  
Herbal Drugs ◽  
Drug Discovery And Development ◽  
History Of ◽  
History Of Use

: Medicinal plants have a long history of use as food and remedy in traditional and modern societies, as well as have been used as herbal drugs and sources of novel bioactive compounds. They provide a wide array of chemical compounds, many of which can not be synthesized via current synthesis methods. Natural products may provide aromatase inhibitory activity through various pathways and may act clinically effective for treating pathologies associated with excessive aromatase secretion including breast, ovarian and endometrial cancers, endometriosis, uterine fibroid, benign prostatic hyperplasia (BPH), prostate cancer, infertility, and gynecomastia. Recent studies have shown that natural products with aromatase inhibitory activity, could also be good options against secondary recurrence of breast cancer by exhibiting chemopreventive effects. Therefore, screening for new plant-based aromatase inhibitors may provide novel leads for drug discovery and development, particularly with increased clinical efficacy and decreased side effects.

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