Bariatric surgery among older adults: a matched case-control study on 30-day and 5-year mortality and changes in Body Mass Index and HbA1c up to 5-years post-operatively

2019 ◽  
Sally Abbott ◽  
Madeleine Hawkes ◽  
Jonathon Hazlehurst ◽  
Helen Horton ◽  
Rishi Singhal ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 4724-4731 ◽  
Nicolás Quezada ◽  
Gregorio Maturana ◽  
María Jesús Irarrázaval ◽  
Rodrigo Muñoz ◽  
Sebastián Morales ◽  

Francisco Félix Caballero ◽  
Ellen A Struijk ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
Esther Lopez-Garcia

Abstract Background Higher levels of ceramides have been linked to several chronic diseases; also there is emerging cross-sectional evidence that ceramides are associated with lower physical functioning. This research assessed for the first time the prospective relationship between ceramide species and impaired lower-extremity function (ILEF) in older adults. Methods Case–control study with 43 cases of ILEF and 86 age- and sex-matched controls, which was nested in the Seniors-ENRICA cohort of community-dwelling older adults. Incident ILEF from 2015 to 2017 was ascertained with the Short Physical Performance Battery. In 2015, 27 ceramide species were measured in plasma by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to assess the longitudinal relationship between ceramides concentration and incidence of ILEF. Results After adjusting for education level, body mass index, alcohol and total energy intake, physical activity, and presence of chronic conditions, some ceramide species were related to 2-year incidence of ILEF. Specifically, the odds ratios of ILEF per 1-SD increase in ceramide concentration were: 1.66 [95% CI = (1.03, 2.68)] for ceramide C14:0, 1.61 (1.00, 2.59) for ceramide C16:0, and 1.64 (1.03, 2.60) for ceramide C16:1 (n-7). In the case of ceramides C16:0 and C16:1 (n-7), a stronger relationship was found in those with a higher body mass index; systolic blood pressure could also mediate the relationship between ceramide C16:1 (n-7) and ILEF (p for interaction = .03). Conclusions Higher plasma levels of ceramides C14:0, C16:0, and C16:1 (n-7) are associated with higher risk of ILEF, and might serve as risk markers for functional decline in older adults.

2019 ◽  
Vol 29 (8) ◽  
pp. 2704-2706 ◽  
Chen D. Wang ◽  
Thiyake Rajaratnam ◽  
Benjamin Stall ◽  
Raed Hawa ◽  
Sanjeev Sockalingam

2018 ◽  
Vol 99 (11) ◽  
pp. 2251-2256 ◽  
Peter C. Coyle ◽  
Jenifer M. Pugliese ◽  
J. Megan Sions ◽  
Mark S. Eskander ◽  
Jennifer A. Schrack ◽  

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