scholarly journals Comparison of Demographic Profile, Laboratory, Epidemiology and Clinical Outcomes in Patients with Native Valve and Prosthetic Valve Endocarditis

2021 ◽  
Vol 24 (3) ◽  
pp. E534-E543
Author(s):  
Hülya YILMAZ AK ◽  
Yasemin ÖZŞAHİN ◽  
Mehmet Ali YESILTAS ◽  
İsmail HABERAL ◽  
Serkan KAHRAMAN ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Prosthetic Valve ◽  
Prosthetic Valve Endocarditis ◽  
Epidemiological Data ◽  
Record System ◽  
Native Valve ◽  
Laboratory Findings ◽  
Mortality And Morbidity ◽  
Native Valve Endocarditis ◽  
Significant Difference

Background: Infective endocarditis (IE) is a heterogenous infection that affects the endothelial surface of the intracardiac structures and other implanted intracardiac devices. We aimed to compare demographical characteristics, causative microorganisms, treatment, and prognosis of prosthetic and native valve endocarditis diagnosed in two separate hospitals. Material and methods: Between 2010 and 2020, patients admitted with the diagnosis of IE were retrospectively included in our multicenter study. Patients' demographic and epidemiological data, clinical characteristics, infected intracardiac structure and sort of valve, culprit microorganisms, laboratory findings, treatment manifestations and in-hospital outcomes with a period of 6 months were obtained from an electronic medical record system. Results: A total of 173 consecutive patients had diagnosed IE, 60.1% (104 patients) of them native valve endocarditis (NVE) and 39.8 % (69 patients) of them prosthetic valve endocarditis (PVE).  Baseline demographic properties were not different except hypertension and atrial fibrillation. Patients with prior hypertension were 25% (26 patients) in NVE; 39.1% (27 patients) in PVE and the difference was statistically significant. Septic shock was significantly higher in the PVE group than the NVE group (7.4% versus 1%; P = .036), and also recurrent endocarditis occurred more frequently in the PVE group than the NVE group (8.8% versus 1%; P = .016). Conclusion: In our study, although we detected higher mean age, HT, RDW and atrial fibrillation rates compared with NVE, we did not detect a significant difference in mortality and morbidity.

The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020

2020 ◽  
Vol 21 (12) ◽  
pp. 1140-1153 ◽  
Author(s):  
Mohammad A. Noshak ◽  
Mohammad A. Rezaee ◽  
Alka Hasani ◽  
Mehdi Mirzaii
Keyword(s):  
Foreign Body ◽  
Infective Endocarditis ◽  
Prosthetic Valve ◽  
Human Life ◽  
Prosthetic Valve Endocarditis ◽  
Surgical Site Infections ◽  
Coagulase Negative Staphylococci ◽  
Native Valve ◽  
Native Valve Endocarditis

Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, endophthalmitis, central nervous system shunt infection, surgical site infections, and foreign body infection. These microorganisms have a significant impact on human life and health and, as typical opportunists, cause peritonitis in individuals undergoing peritoneal dialysis. Moreover, it is revealed that these potential pathogens are mainly related to the use of indwelling or implanted in a foreign body and cause infective endocarditis (both native valve endocarditis and prosthetic valve endocarditis) in patients. In general, approximately eight percent of all cases of native valve endocarditis is associated with CoNS species, and these organisms cause death in 25% of all native valve endocarditis cases. Moreover, it is revealed that methicillin-resistant CoNS species cause 60 % of all prosthetic valve endocarditis cases. In this review, we describe the role of the CoNS species in infective endocarditis, and we explicated the reported cases of CoNS infective endocarditis in the literature from 2000 to 2020 to determine the role of CoNS in the process of infective endocarditis.

Prosthetic valve endocarditis

ESC CardioMed ◽  
2018 ◽  
pp. 1720-1723
Author(s):  
José A. San Román ◽  
Javier López
Keyword(s):  
Computed Tomography ◽  
Infective Endocarditis ◽  
Antibiotic Treatment ◽  
Prosthetic Valve ◽  
Photon Emission ◽  
Clinical Manifestations ◽  
Prosthetic Valve Endocarditis ◽  
Native Valve ◽  
Native Valve Endocarditis ◽  
Duke Criteria

Prosthetic valve endocarditis (PVE) complicates the clinical course of 1–6% of patients with prosthetic valves and it is one of the types of infective endocarditis with the worst prognosis. In early-onset PVE (that occurs within the first year after surgery), the microbiological profile is dominated by staphylococci. In late-onset PVE, the microorganisms are similar to native valve endocarditis. Clinical manifestations are very variable and depend on the causative microorganism. The diagnosis is established with the modified Duke criteria although they yield lower diagnostic accuracy than in native valve endocarditis. Transoesophageal echocardiography is the main imaging technique in everyday clinical practice in PVE as the sensitivity is higher than transthoracic echocardiography. The findings of other techniques, as cardiac computed tomography (CT), positron emission tomography/CT, or single-photon emission computed tomography/CT have been recently recognized as new major diagnostic criteria and can be very useful in cases with a high level of clinical suspicion and negative echocardiography. Empirical antibiotic treatment should cover the most frequent microorganisms, especially staphylococci. Once the microbiological diagnosis is made, the antibiotic treatment is similar to native valve infective endocarditis, except for the addition of rifampicin in staphylococcal PVE and a longer length (up to 6 weeks) of the treatment. Surgical indications are also similar to native valve endocarditis, heart failure being the most common and embolic prevention the most debatable. Prognosis is bad, and during the follow-up, a team experienced with endocarditis is needed. Patients with a history of PVE should receive antibiotic prophylaxis if they undergo invasive dental manipulations.

scholarly journals Comparable perioperative outcomes and mid-term survival in prosthetic valve endocarditis and native valve endocarditis

2018 ◽  
Vol 54 (6) ◽  
pp. 1067-1072 ◽  
Author(s):  
Makoto Mori ◽  
Kayoko Shioda ◽  
Max Jordan Nguemeni Tiako ◽  
Syed Usman Bin Mahmood ◽  
Abeel A Mangi ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Prosthetic Valve Endocarditis ◽  
Perioperative Outcomes ◽  
Native Valve ◽  
Term Survival ◽  
Native Valve Endocarditis

scholarly journals Modified Commando Procedure in Complicated Infective Endocarditis - A Case Series.

2020 ◽  
Author(s):  
Po Sung Chen ◽  
Chungyi Chang ◽  
Yicheng Chuang ◽  
Ichen Chen ◽  
Tingchao Lin
Keyword(s):  
Infective Endocarditis ◽  
Prosthetic Valve ◽  
Case Series ◽  
Prosthetic Valve Endocarditis ◽  
Surgical Mortality ◽  
Native Valve ◽  
Case Presentation ◽  
Native Valve Endocarditis ◽  
Fibrous Body ◽  
Urgent Surgery

Abstract Background: Complicated infective endocarditis (IE) with perivalvular abscess and destruction of intervalvular fibrous body (IFB) has high mortality risk and requires emergent or urgent surgery mostly. Case presentation: We presented four patients with complicated infective endocarditis combined with perivalvular abscess and IFB destruction. Three patients had prosthetic valve endocarditis and one patient had native valve endocarditis. They all received modified Commando procedure successfully. No surgical mortality or re-exploration for bleeding. Conclusions: We suggest that modified Commando procedure may have some benefit in improving survival rate of patients with complicated IE and reducing complications.

scholarly journals Modified commando procedure in complicated infective endocarditis ─ a case series

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Posung Chen ◽  
Chungyi Chang ◽  
Yicheng Chuang ◽  
Ichen Chen ◽  
Tingchao Lin
Keyword(s):  
Infective Endocarditis ◽  
Prosthetic Valve ◽  
Case Series ◽  
Prosthetic Valve Endocarditis ◽  
Surgical Mortality ◽  
Native Valve ◽  
Case Presentation ◽  
Native Valve Endocarditis ◽  
Fibrous Body ◽  
Urgent Surgery

Abstract Background Complicated infective endocarditis (IE) with perivalvular abscess and destruction of intervalvular fibrous body (IFB) has high mortality risk and requires emergent or urgent surgery mostly. Case presentation We presented four patients with complicated infective endocarditis combined with perivalvular abscess and IFB destruction. Three patients had prosthetic valve endocarditis and one patient had native valve endocarditis. They all received modified Commando procedure successfully. No surgical mortality or re-exploration for bleeding. Conclusions We suggest that modified Commando procedure may have some benefit in improving survival rate of patients with complicated IE and reducing complications.

Abstract 15695: Contemporary Trends and Outcomes of Prosthetic Valve Infective Endocarditis in the United States: Insights From the Nationwide Inpatient Sample

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Muhammad KHAN ◽  
Muhammad Munir ◽  
Muhammad U Khan ◽  
Sudarshan Balla
Keyword(s):  
Logistic Regression ◽  
Hospital Mortality ◽  
Prosthetic Valve ◽  
Care Delivery ◽  
Prosthetic Valve Endocarditis ◽  
The United States ◽  
Analysis Of Covariance ◽  
Prior History ◽  
Native Valve ◽  
Mortality And Morbidity

Introduction: Prosthetic valve endocarditis (PVE) carries high mortality and morbidity as compared to native valve endocarditis (NVE). Hypothesis: Hospital outcomes have shown improvement over the years in PVE Methods: We used the National Inpatient Sample from 2000 to 2017 to identify patients admitted with PVE who 18 years and older using ICD-9-CM and ICD-10 codes (421.0,421.1,421.9, V433.0, I33.0, I33.9, and Z95.2). Patients with prior history of prosthetic valve were identified using the respective ICD-9. Risk-adjusted rates were calculated using an Analysis of Covariance (ANCOVA) with the Generalized Linear Model (GLM). Trends were assessed with linear regression and Pearson’s Chi-square when appropriate. Binomial logistic regression was used to assess predictors of in-hospital mortality. Results: We identified 43,602 hospitalizations for PVE. PVE increased from 1803 in 2000 to 3450 in 2017. Risk-adjusted mortality decreased from 10.7% in 2002 to 7.3% in 2017 (P<0.01)(Figure). Logistic regression analysis on mortality showed increase association with age (OR, 1.021[1.017-1.024], Hispanics (OR, 1.493[1.296-1.719],p<0.01) and patients with drug abuse(OR, 1.233[1.05-1.449],p=0.01). co-morbid conditions like congestive heart failure (OR, 1.511[1.366-1.673],p<0.01), renal failure (OR, [1.572[1.427-1.732],p<0.01) and weight loss (OR, 1.425[1.093-1.419],p<0.01) were also associated with higher mortality. Conclusions: Adjusted in-hospital mortality from PVE has trended down over the years. The findings reflect improved health care delivery over the study years for patients with PVE.

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