scholarly journals New Definition of Sepsis

2013 ◽  
Vol 2 (1) ◽  
pp. 37
Author(s):  
Fuzhou Wang
Keyword(s):  
Septic Shock ◽  
Intensive Care ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Organ Dysfunction ◽  
Medical Science ◽  
Accurate Diagnosis ◽  
Causes Of Mortality ◽  
New Challenges ◽  
Definition Of

Sepsis or septic shock is one of the major causes of mortality in intensive care medicine. How to define and how to make an accurate diagnosis possess critical implications for patients and intensive caregivers. With the development of modern medical science, new challenges rose for how to re-define sepsis and also revision is needed. Should we add organ dysfunction to the diagnostic criteria of systemic inflammatory response syndrome, and whether are there early symptoms or signs of organ dysfunction need to be considered critically. May be the new definition of sepsis can save more lives.

scholarly journals To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

2017 ◽  
Vol 44 (03) ◽  
pp. 224-238 ◽  
Author(s):  
Douglas Kell ◽  
Etheresia Pretorius
Keyword(s):  
Septic Shock ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Prion Diseases ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
Multiple Organ Dysfunction ◽  
Helical Content

AbstractA well-established development of increasing disease severity leads from sepsis through systemic inflammatory response syndrome, septic shock, multiple organ dysfunction syndrome, and cellular and organismal death. Less commonly discussed are the equally well-established coagulopathies that accompany this. We argue that a lipopolysaccharide-initiated (often disseminated intravascular) coagulation is accompanied by a proteolysis of fibrinogen such that formed fibrin is both inflammatory and resistant to fibrinolysis. In particular, we argue that the form of fibrin generated is amyloid in nature because much of its normal α-helical content is transformed to β-sheets, as occurs with other proteins in established amyloidogenic and prion diseases. We hypothesize that these processes of amyloidogenic clotting and the attendant coagulopathies play a role in the passage along the aforementioned pathways to organismal death, and that their inhibition would be of significant therapeutic value, a claim for which there is considerable emerging evidence.

scholarly journals Performance of scores in the prediction of clinical outcomes in patients admitted from the emergency service

2021 ◽  
Vol 29 ◽  
Author(s):  
Luana Matuella Figueira da Silva ◽  
Luciano Passamini Diogo ◽  
Letícia Becker Vieira ◽  
Fabiano Da Costa Michielin ◽  
Michelle Dornelles Santarem ◽  
...  
Keyword(s):  
Septic Shock ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Clinical Outcomes ◽  
Emergency Service ◽  
Emergency Services ◽  
Early Recognition ◽  
Systemic Inflammatory Response ◽  
The Relationship

Objective: to evaluate the performance of the quickSOFA scores and Systemic Inflammatory Response Syndrome as predictors of clinical outcomes in patients admitted to an emergency service. Method: a retrospective cohort study, involving adult clinical patients admitted to the emergency service. Analysis of the ROC curve was performed to assess the prognostic indexes between scores and outcomes of interest. Multivariate analysis used Poisson regression with robust variance, evaluating the relationship between variables with biological plausibility and outcomes. Results: 122 patients were selected, 58.2% developed sepsis. Of these, 44.3% had quickSOFA ≥2 points, 87% developed sepsis, 55.6% septic shock and 38.9% died. In the evaluation of Systemic Inflammatory Response Syndrome, 78.5% obtained results >2 points; of these, 66.3% developed sepsis, 40% septic shock and 29.5% died. quickSOFA ≥2 showed greater specificity for diagnosis of sepsis in 86% of the cases, for septic shock 70% and for mortality 64%, whereas the second score showed better results for sensitivity with diagnosis of sepsis in 87.5%, septic shock in 92.7% and death in 90.3%. Conclusion: quickSOFA showed by its practicality that it can be used clinically within the emergency services, bringing clinical applicability from the risk classification of patients for the early recognition of unfavorable outcomes.

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