Maternal  Serum  Insulin  in  Hypertensive  Disorders  of  Pregnancy  and Neonatal Outcome

Background: Abnormal uric acid levels in patients with preeclampsia and eclampsia affect both maternal and fetal outcome negatively. This study was done to know the alterations in these serum levels in comparison to normal pregnancy and also among various hypertensive disorders of pregnancies.Methods: Maternal serum uric acid levels were compared among cases and controls in relation to disease severity, mode of delivery, maternal outcome.Results: In group A (cases), 10 patients had raised uric acid levels, of which 5 were severe preeclampsia, 3 were eclampsia and 2 cases of chronic hypertension superimposed preeclampsia. P value is 0.001 (highly significant). Also serum uric acid is significantly elevated in hypertensive disorders of pregnancy compared with controls with a P value of 0.001.Conclusions: Significant correlation was observed between maternal serum uric acid, disease severity and maternal outcome. Our study concludes that uric acid can be considered as a sensitive prognostic indicator of severity in hypertensive disorders of pregnancy.

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Utility of time of onset of hypertension, ADMA and TAS in predicting adverse neonatal outcome in hypertensive disorders of pregnancy

Fetal and Pediatric Pathology ◽

10.1080/15513815.2019.1619205 ◽

2019 ◽

Vol 38 (6) ◽

pp. 460-476

Author(s):

Angelin Jeba Malar Abraham ◽

Zachariah Bobby ◽

Latha Chaturvedula ◽

Vickneshwaran Vinayagam ◽

Habeebullah Syed ◽

...

Keyword(s):

Neonatal Outcome ◽

Hypertensive Disorders Of Pregnancy ◽

Adverse Neonatal Outcome ◽

Hypertensive Disorders

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Placental production and maternal serum and urine levels of inhibin A and activin A are modified by antihypertensive therapy in hypertensive disorders of pregnancy

Clinical Endocrinology ◽

10.1111/j.1365-2265.2008.03426.x ◽

2009 ◽

Vol 70 (6) ◽

pp. 924-931 ◽

Cited By ~ 9

Author(s):

Asma Khalil ◽

Eric Jauniaux ◽

Kevin Harrington ◽

Shanthi Muttukrishna

Keyword(s):

Antihypertensive Therapy ◽

Activin A ◽

Maternal Serum ◽

Hypertensive Disorders Of Pregnancy ◽

Inhibin A ◽

Hypertensive Disorders ◽

Urine Levels ◽

Serum And Urine

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Maternal serum angiopoietin-2 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy

Prenatal Diagnosis ◽

10.1002/pd.2307 ◽

2009 ◽

Vol 29 (9) ◽

pp. 847-851 ◽

Cited By ~ 8

Author(s):

Ranjit Akolekar ◽

Davide Casagrandi ◽

Evdoxia Skyfta ◽

Abubaker Abdalla Ahmed ◽

Kypros H. Nicolaides

Keyword(s):

Maternal Serum ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Angiopoietin 2

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Association between maternal serum beta human chorionic gonadotropin levels and hypertensive disorders of pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203052 ◽

2020 ◽

Vol 9 (8) ◽

pp. 3157

Author(s):

Archana Kumari ◽

Vahini M.

Keyword(s):

Pregnant Women ◽

Late Onset ◽

Maternal Serum ◽

Severe Preeclampsia ◽

Control Group ◽

Study Group ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Significant Difference ◽

Β Hcg

Background: A major challenge in obstetrics is early identification of hypertensive disorders of pregnancy (HDP). This study was performed to determine the association between elevated maternal serum β-hCG levels and HDP, the correlation between serum β-hCG level and severity of preeclampsia and to determine the value of serum β-hCG level as a diagnostic marker for early diagnosis of HDP.Methods: This was a hospital based observational study conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi on 375 pregnant women with period of gestation more than 20 weeks, including 250 pregnant women with HDP as study group and 125 normotensive pregnant women as controls. Serum β-hCG concentration was measured and its level was compared between two groups.Results: The maternal mean serum β-hCG levels (51161.08±30038.21 IU/L) of study group of HDP were higher than the normotensive control group (17603.23±16748.21 IU/L). In non-severe preeclampsia, the mean serum levels were 36417.32±23876.74 IU/L while in severe preeclampsia, 60030.34±28771.31 IU/L. There was statistically significant difference (p<0.001) with higher levels in early onset preeclamptic mothers than late onset preeclampsia. The cut-off point of β-hCG for predicting HDP was 32077 IU/L with sensitivity of 65% and specificity of 86%.Conclusions: Serum β-hCG level is higher in HDP when compared to normotensive women. Higher levels of β-hCG are associated with increasing severity of hypertensive disorders of pregnancy. The utility of serum β-hCG as a diagnostic test is limited because of low sensitivity and difficulty in deciding the cut-off value.

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