scholarly journals Association between maternal serum beta human chorionic gonadotropin levels and hypertensive disorders of pregnancy

2020 ◽  
Vol 9 (8) ◽  
pp. 3157
Author(s):  
Archana Kumari ◽  
Vahini M.
Keyword(s):  
Pregnant Women ◽  
Late Onset ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Study Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference ◽  
Β Hcg

Background: A major challenge in obstetrics is early identification of hypertensive disorders of pregnancy (HDP). This study was performed to determine the association between elevated maternal serum β-hCG levels and HDP, the correlation between serum β-hCG level and severity of preeclampsia and to determine the value of serum β-hCG level as a diagnostic marker for early diagnosis of HDP.Methods: This was a hospital based observational study conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi on 375 pregnant women with period of gestation more than 20 weeks, including 250 pregnant women with HDP as study group and 125 normotensive pregnant women as controls. Serum β-hCG concentration was measured and its level was compared between two groups.Results: The maternal mean serum β-hCG levels (51161.08±30038.21 IU/L) of study group of HDP were higher than the normotensive control group (17603.23±16748.21 IU/L). In non-severe preeclampsia, the mean serum levels were 36417.32±23876.74 IU/L while in severe preeclampsia, 60030.34±28771.31 IU/L. There was statistically significant difference (p<0.001) with higher levels in early onset preeclamptic mothers than late onset preeclampsia. The cut-off point of β-hCG for predicting HDP was 32077 IU/L with sensitivity of 65% and specificity of 86%.Conclusions: Serum β-hCG level is higher in HDP when compared to normotensive women. Higher levels of β-hCG are associated with increasing severity of hypertensive disorders of pregnancy. The utility of serum β-hCG as a diagnostic test is limited because of low sensitivity and difficulty in deciding the cut-off value.

scholarly journals Do N-Terminal Pro-C-Type Natriuretic Peptide Levels Relate to Severity of Preeclampsia?

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Dogan Vatansever ◽  
Pınar Vatansever ◽  
Burak Giray ◽  
A. Aktug Ertekin ◽  
Serpil Bilsel
Keyword(s):  
Pregnant Women ◽  
Natriuretic Peptide ◽  
Venous Blood ◽  
Severe Preeclampsia ◽  
Study Group ◽  
Women Patients ◽  
Significant Difference ◽  
Mild Preeclampsia ◽  
Age Range ◽  
Circulating Levels

Aim. To compare the plasma N-terminal pro-C-type natriuretic peptide concentrations of normotensive pregnant women, patients with mild preeclampsia, and patients with severe preeclampsia. Methods. We collected venous blood samples from 25 normotensive pregnant women, 15 patients with mild preeclampsia, and 15 patients with severe preeclampsia. The women were at 30th to 40th weeks of gestation and in an age range of 20 to 35. The N-terminal pro-C-type natriuretic peptide levels were measured by ELISA. Statistical comparisons were made by one-way analysis of variance, Kruskal–Wallis, and Mann–Whitney U tests. Results. The median (interquartile range-IQR) values of the N-terminal pro-C-type natriuretic peptide were 6.48 (3.33) pmol/L in the normotensive women group, 7.37 (3.43) pmol/L in patients with mild preeclampsia, and 11.52 (6.13) pmol/L in patients with severe preeclampsia. The N-terminal pro-C-type natriuretic peptide was significantly elevated in the severe preeclampsia study group (P<0.001), whereas there was no significant difference between those with mild preeclampsia and the normotensive groups (P>0.05). Conclusion. Our data indicate that the plasma concentration of the N-terminal pro-C-type natriuretic peptide is significantly increased in patients with severe preeclampsia, but not in patients with mild preeclampsia. The severity of preeclampsia may be related to the circulating levels of the N-terminal pro-C-type natriuretic peptide concentrations.

Maternal Serum Haptoglobin Levels as a Marker of Preterm Premature Rupture of Membranes

2020 ◽  
Author(s):  
Gul Nihal Buyuk ◽  
Z.Asli Oskovi-Kaplan ◽  
Huseyin Durukan
Keyword(s):  
Pregnant Women ◽  
Maternal Serum ◽  
Control Group ◽  
Premature Rupture ◽  
Roc Curve Analysis ◽  
Membrane Rupture ◽  
Preterm Premature Rupture ◽  
Serum Haptoglobin ◽  
Significant Difference ◽  
The Mean

Abstract Objective We aimed to investigate the prognostic value of maternal serum haptoglobin levels in patients presenting with preterm premature rupture of fetal membranes (PPROM) during the second and the third trimesters of pregnancy. Methods In this case control study, 60 patients were recruited (30 pregnant women with PPROM between 26–34 weeks of gestation and 30 healthy, gestational-age-matched pregnant women without PPROM). White blood cell count (WBC), interleukin 6 (IL-6), C-reactive protein (CRP), sedimentation rate, and haptoglobin levels were measured. Results The mean age, gestational week, gravida, and parity of the 2 groups were statistically comparable (P>0.001). There was a statistically significant difference between the 2 groups in terms of haptoglobin values (p<0.001). The mean haptoglobin level was 115.5+33.1(mg/dl) in the PPROM group and 66.5+42.6 (mg/dl) in the control group. ROC curve analysis was performed to determine whether the level of haptoglobin alone could diagnose PPROM as an independent marker. It was shown that the level of 94.5 mg/dL for haptoglobin could indicate the diagnosis of PPROM with 80% sensitivity and specificity Conclusion Maternal serum haptoglobin levels may be a diagnostic marker for suspected PPROM cases when membrane rupture diagnosis is not accurate based on physical examination and other diagnostic tests.

scholarly journals A Comparative Study of Relationship between Micronutrients and Gestational Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Farideh Akhlaghi ◽  
Seyyed Majid Bagheri ◽  
Omid Rajabi
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Gestational Age ◽  
Control Group ◽  
Study Group ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Significant Difference ◽  
Micronutrient Concentration ◽  
And Control

In this paper, we studied the relation between the micronutrient and gestational diabetes. Therefore, we measured micronutrient concentration including Ni, Al, Cr, Mg, Fe, Zn, Cu, and Se in serum of women with gestational diabetes between 24 and 28 weeks of gestational age (study group) who had inclusion criteria and comparison with micronutrient levels in normal pregnant women with same gestational age (control group). Results showed that there was no significant difference between the serum micronutrient level (Ni, Al, Cr, Mg, Zn, Cu, Se) in study and control groups except serum level of iron which in serum of gestational diabetic women was lower than normal pregnant women and difference was significant.

scholarly journals Efficiency evaluation of the improved treatment and prevention complex in pregnant women after assisted reproductive technologies

2021 ◽  
pp. 26-31
Author(s):  
V.O. Beniuk ◽  
L.M. Vygivska ◽  
I.V. Maidannyk ◽  
T.V. Kovaliuk ◽  
O.O. Chorna ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Assisted Reproductive Technologies ◽  
First Trimester ◽  
Reproductive Technologies ◽  
Control Group ◽  
Significant Difference ◽  
Β Hcg ◽  
Arginine Aspartate ◽  
Micronized Progesterone

Study objective: to determine the role and effectiveness of the proposed therapeutic and preventive complex and psychoemotional correction of hormonal disorders in the pregnancy dynamics after assisted reproductive technologies (ART) to improve the antenatal observation and prevention of obstetric and perinatal complications.Materials and methods. The study included 299 pregnant women: the main group included 249 women whose pregnancy occurred as an ART result; the control group included 50 pregnant women with spontaneous pregnancy. Therapeutic and prophylactic complex for pregnant women after ART included: micronized progesterone, magnesium oxide, folic acid, L-arginine aspartate, ω3-polyunsaturated fatty acids and long-term psychological correction on the eve of the ART program, at 8–10, 16–18 and 28–30 weeks of pregnancy. Results. There was a significant increase in the β-chorionic gonadotropin (β-hCG) level in women of the study groups in the first trimester of pregnancy against the background of the proposed treatment. Mean β-HCG value at 7–8 weeks of gestation in the subgroup IA exceeded the subgroup IB by 37% (p <0.05), in subgroup IIA it exceeded the subgroup IIB by 33% (p <0.05). The mean β-hCG value in subgroups IIIA and IIIB did not have a significant difference in the dynamics of the first trimester compared with the control group and among themselves (p >0.05).Mean progesterone value at 7–8 weeks of gestation in subgroup IA increased by 38% in comparison with pregnant women who received the conventional treatment complex (p <0.05), in subgroup IIA it was 73% higher than in subgroup IIB (p <0.05). There was no significant difference in the progesterone level in subgroups IIIA and IIIB in the dynamics of the first trimester.The average cortisol value at 23–24 weeks of pregnancy in subgroup IA decreased by 42% (p <0.05), in pregnant women with endocrine infertility against the background of the proposed treatment complex it was 62% less than in subgroup IIB (p <0.05). The average cortisol level in women with a male factor of infertility was 63% lower than in subgroup IIIB against the background of the proposed complex (p <0.05).Conclusion. Advanced therapy with micronized progesterone in combination with magnesium saturation, L-arginine aspartate, folic acid, ω-3 polyunsaturated fatty acids, as well as long-term psychoemotional correction is appropriate and effective compared to conventional therapy for pregnant women.

Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

2020 ◽  
Author(s):  
Demet Aydogan kırmızı ◽  
Emre Baser ◽  
Taylan Onat ◽  
Melike Demir Caltekin ◽  
Mustafa Kara ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Late Onset ◽  
Hematological Parameters ◽  
Growth Restriction ◽  
Control Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference

Abstract Purpose To compare the rates obtained from hematological parameters in cases of late-onset idiopathic fetal growth restriction (FGR) with healthy pregnancies and to evaluate the effect on neonatal outcomes. Methods The study group consisted of 63 pregnant women with late-onset idiopathic FGR and the control group consisted of 91 healthy pregnant women. The determined rates were calculated from the control hemograms of patients at 28 weeks. Both groups were compared for neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other parameters. Results NLR, leukocyte and neutrophil levels were significantly higher in the FGR group (p<0.05). There was no significant difference in PLR, platelet and lymphocyte levels between the groups (p>0.05). To predict FGR, the best cut-off value of NLR was determined to be 4.11 with 56% sensitivity and 88% specificity values. Conclusion Neutrophil, lymphocyte and platelet interactions have an important role in FGR development. Inflammation can be involved in the etiopathogenesis in late-onset FGR.

Activated Macrophages in Preeclampsia

Pteridines ◽  
1993 ◽  
Vol 4 (3) ◽  
pp. 144-148
Author(s):  
H. Schröcksnadel ◽  
D. Fuchs ◽  
M. Herold ◽  
H. Wachter ◽  
O. Dapunt
Keyword(s):  
Pregnant Women ◽  
Macrophage Activation ◽  
Tnf Alpha ◽  
Activated Macrophages ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Difference

SummaryNeopterin (serum. urine) and other markers of macrophage activation (lL-1 IL-6, TNF alpha) were compared in preeclamptic patients and healthy pregnant controls. The prepartal urine neopterin median in preeclampsia (337 μmol/mol creat.) was 33% higher than that of healthy pregnant controls (253 μmol/mol creat.). There was no statistically significant difference between the groups (p = 0.08). In plasma there were no statistically significant differences in cytokine concentrations between healthy pregnant and nonpregnant controls with the exception of neopterin. that showed higher values in pregnant women (p = O.OO4). Elevated levels of IL-6. TNF-alpha and neopterin were observed in hypertensive women. Differences to healthy pregnant controls were statistically significant for IL-6 (p = 0.008). TNF-alpha (p = 0.009) and neopterin (p=0.04) and were more pronounced in severe forms of the disease. These three parameters of monocytic origin showed positive significant correlations amongst each other. A participation of macrophages in the pathomechanism of hypertensive disorders of pregnancy can thus be assumed.

scholarly journals Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Elena Timokhina ◽  
Alexander Strizhakov ◽  
Sapiyat Ibragimova ◽  
Evgeny Gitel ◽  
Irina Ignatko ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Pregnant Women ◽  
Blood Vessels ◽  
Late Onset ◽  
Plasma Concentrations ◽  
Normal Pregnancy ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Threatening Condition ◽  
Early Onset Preeclampsia

Introduction. Preeclampsia (PE) is a life-threatening condition for the mother, the fetus, and the newborn. Matrix metalloproteinases (MMP) participate in the two primary stages of PE: remodeling of blood vessels at the stage of placental formation and the development of hypertension due to damage to the basement membrane of blood vessels. The object of the present study was to reveal the role of MMP-2 and MMP-9 in the development of severe preeclampsia. Materials and Methods. We conducted a retrospective study that included 92 pregnant women at a gestational age of 26-38 weeks, of which the principal group consisted of 61 patients with severe PE. We divided the principal group into two subgroups: the first subgroup was designated the severe early-onset preeclampsia (EO-PE) group and consisted of 30 pregnant women. The second group was designated the severe late-onset preeclampsia (LO-PE) group, comprising 31 patients. We determined the plasma concentrations of MMPs 2 and 9 in the groups with an ELISA. Results. In the group of PE patients with both EO-PE and LO-PE, the level of MMP-2 was significantly higher compared to the women undergoing normal pregnancy; and we observed no significant differences when we compared the levels of MMP-2 in the subgroups with EO-PE and LO-PE. Analysis of the concentrations of MMP-9 in EO-PE and LO-PE subgroups revealed attenuated levels of MMP-9 in both groups relative to the control group. We also noted a diminished level of MMP-9 in the EO-PE group compared to the LO-PE group. Conclusions. The significantly increased levels of MMP-2 in women—both in the EO-PE and LO severe PE subgroups—explain the participation of this enzyme in endothelial dysfunction in the second stage of severe PE. A diminution in MMP-9 in the EO-PE group confirmed the participation of MMP-9 in the process of spiral artery transformation.

scholarly journals Study of role of Magnesium sulfate in prevention of eclampsia

2017 ◽  
Vol 6 (12) ◽  
pp. 5497
Author(s):  
Srinivas N. Gadappa ◽  
Pratibha Dixit
Keyword(s):  
Magnesium Sulfate ◽  
Disease Progression ◽  
Perinatal Outcome ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Study Group ◽  
Severity Of Disease ◽  
Drug Of Choice ◽  
Significant Difference ◽  
And Control

Background: Hypertensive disorders of pregnancy have a clinical spectrum ranging from non-severe to severe preeclampsia and then potentially to eclampsia. Magnesium sulfate is drug of choice for women with eclampsia and now adapted for prophylaxis of seizures in women with preeclampsia.Methods: It is randomized clinical trial, including 876 patients with preeclampsia fulfilling inclusion criteria. Patients with severe preeclampsia received anticonvulsant prophylaxis with magnesium sulfate. Patients with non-severe preeclampsia were randomized in two groups study group and control group. Patients in study group had received anticonvulsant prophylaxis with magnesium sulfate. The data obtained was analyzed with respect to maternal and perinatal outcome, severity of disease progression and adverse reactions of magnesium sulphate in each group.Results: In this study statistically, significant difference was seen with respect to severity of disease progression and incidence of eclampsia among study and control group.Conclusions: Administration of Magnesium sulfate in patients with non-severe preeclampsia does not affect the progress of labour or perinatal outcome, on contrary it improves maternal outcome by reducing incidence of eclampsia and progression of disease, without significant side effect of drug. 

scholarly journals Hemodynamic Profile and Cardiac Morphometry in Normotension and Severe Preeclamptic Pregnant Women

2019 ◽  
pp. 27
Author(s):  
Noroyono Wibowo ◽  
Peby M Lestari
Keyword(s):  
Pregnant Women ◽  
Early Onset ◽  
Late Onset ◽  
Left Ventricular ◽  
Severe Preeclampsia ◽  
The Other ◽  
Control Group ◽  
Hemodynamic Profile ◽  
Onset Group ◽  
Early Onset Group

Abstract Objective: To identify the differences of hemodynamic profile and morphometric changes of maternal heart in normotensive and severe preeclampsia (early-onset and late-onset) pregnant women. Method: Cross-sectional study on consecutively selected 34 pregnant women which divided into three groups: normotensive group (n = 12), early-onset group (n = 11), and the late-onset group (n = 11). Conducted in the ER and inpatient care unit of Obstetrics and Gynecology Department, Faculty of Medicine Sriwijaya University / Dr. Moh. Hoesin Hospital Palembang, from April 2015 - June 2015. Results: There are significant differences in CO and SVR among three groups. In early onset groups, CO values ​​are lower (3.4 + 0:27, p <0.001) with higher SVR (3100.2 + 261.3, p <0.001) compared the other two groups. There is increased of SVR in preeclamptic group compared to control, where SVR is higher in the early onset compared to late-onset group (3100.2 + 261.3 vs 2217.1 + 407.8, p <0.001), as well as differences between groups in cardiac index variables, except in the early onset group and controls (p = 0.045). In blood pressure and MAP variable, we only notice difference between the early onset group and control (p <0.001) as well as late-onset group and controls (p <0.001). There are significant differences in LVMi, LVID and LVPWT among three groups, in which the control group was lower than the other two groups (p <0.001; p = 0.049; p = 0.009), but similar in early and late-onset groups (98.7 (86.5-203) vs 132 (77.7-17.6); 4.7 (0.4) vs 4.8 (0.5); 1.1 (0.7-1.3) vs. 1.1 (0.8-1.6)). While RWT relatively similar among the three study groups (p = 0.264). A post hoc analysis showed no differences in maternal heart morphometry in early onset and late-onset group (p> 0.05). Conclusions: In severe preeclampsia there are changes in hemodynamic, ventricular morphometry, and left ventricular function. But the changes that occurred seems to be more evident in the early onset preeclampsia group of  compared than late-onset preeclampsia. Keywords: Normotensive, early onset PEB, PEB late-onset, hemodynamic profile, cardiac morphometry.

scholarly journals Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Xue Zhou ◽  
Ben Li ◽  
Chao Wang ◽  
Zhihong Li
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Hs Crp ◽  
The Impact

Objective: To investigate the effect of vitamin D deficiency on the levels of thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPO-Ab), interleukin-1 (IL-1) and high-sensitivity C-reactive protein (hs-CRP) in pregnant women with early pregnancy complicated by subclinical hypothyroidism. Methods: A total of 172 pregnant women with subclinical hypothyroidism in the first trimester diagnosed and treated in a given hospital from August 2014 to May 2018 were selected, and their levels of vitamin D were determined. Depending on the abnormality of their vitamin D levels, the study participants were divided into two groups: the study group (vitamin D≤20 ng/L) and the control group (vitamin D>20 ng/L). The levels of TSH, TPO-Ab, IL-1 and hsCRP in the two groups were measured. Results: The levels of TSH, hsCRP and TPO-Ab in the study group were significantly higher than those in the control group (P < 0.05). The comparison between the two groups in terms of IL-1 showed no statistically significant difference. Conclusion: Vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels. doi: https://doi.org/10.12669/pjms.36.6.1982 How to cite this:Zhou X, Li B, Wang C, Li Z. Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.1982 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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