scholarly journals Inducible Nitric Oxide Distribution in the Fatty Liver of a Mouse with High Fat Diet-Induced Obesity

2010 ◽  
Vol 59 (5) ◽  
pp. 595-604 ◽  
Author(s):  
Seung-Kwon HA ◽  
Chanhee CHAE
Keyword(s):  
Nitric Oxide ◽  
Fatty Liver ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Inducible Nitric Oxide

Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet

2004 ◽  
Vol 326 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Yi Chen ◽  
Shigenari Hozawa ◽  
Sadaaki Sawamura ◽  
Shinkichi Sato ◽  
Naoto Fukuyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hepatic Fibrosis ◽  
Inducible Nitric Oxide Synthase ◽  
High Fat Diet ◽  
High Fat ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals AFomitopsis pinicola JesengFormulation Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity

2016 ◽  
Vol 2016 ◽  
pp. 1-10
Author(s):  
Hoe-Yune Jung ◽  
Yosep Ji ◽  
Na-Ri Kim ◽  
Do-Young Kim ◽  
Kyong-Tai Kim ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Cholesterol Biosynthesis ◽  
Viscum Album ◽  
Control Group ◽  
High Fat ◽  
Fomitopsis Pinicola ◽  
Acanthopanax Senticosus ◽  
Nonalcoholic Fatty Liver ◽  
Diet Induced Obesity

This study investigated the antiobesity effect of an extract of the Fomitopsis pinicola Jeseng-containing formulation (FAVA), which is a combination of four natural components:Fomitopsis pinicola Jeseng;Acanthopanax senticosus;Viscum album coloratum; andAllium tuberosum. High-fat diet- (HFD-) fed male C57BL/6J mice were treated with FAVA (200 mg/kg/day) for 12 weeks to monitor the antiobesity effect and amelioration of nonalcoholic fatty liver diseases (NAFLD). Body and white adipose tissue (WAT) weights were reduced in FAVA-treated mice, and a histological examination showed an amelioration of fatty liver in FAVA-treated mice without decreasing food consumption. Additionally, FAVA reduced serum lipid profiles, leptin, and insulin levels compared with the HFD control group. The FAVA extract suppressed lipogenic mRNA expression levels from WAT concomitantly with the cholesterol biosynthesis level in the liver. These results demonstrate the inhibitory effects of FAVA on obesity and NAFLD in the diet-induced obese (DIO) mouse model. Therefore, FAVA may be an effective therapeutic candidate for treating obesity and fatty liver caused by a high-fat diet.

scholarly journals Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eveliina Tauriainen ◽  
Mira Luostarinen ◽  
Essi Martonen ◽  
Piet Finckenberg ◽  
Miia Kovalainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fatty Liver ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Ad Libitum ◽  
Metabolic Performance

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% ofad libitumenergy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

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