scholarly journals Counseling provided by the pharmacist in Romanian community pharmacy: the patients’ perspective

2014 ◽  
Vol 87 (2) ◽  
pp. 113-118
Author(s):  
Mihaela Ela Iancu ◽  
Camelia Bucsa ◽  
Andreea Maria Farcas ◽  
Daniel Corneliu Leucuta ◽  
Adriana Dincu ◽  
...  
Keyword(s):  
Side Effects ◽  
Patient Education ◽  
Community Pharmacy ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Drug Reactions ◽  
Interventional Study ◽  
Length Of Treatment ◽  
Laboratory Results ◽  
Patients Perspective

Background and aims. Patient education is a critical task that may be carried out by the pharmacists, especially in the context of contemporary pharmacists’ roles, which tend to be closer to patients and their needs. This study aimed to evaluate the counseling provided by the pharmacist in the community pharmacy, from the patient’s perspective.Patients and methods. We conducted a prospective, non-interventional study in 520 pharmacies from 10 Romanian counties across the country. The first 10 visitors of the pharmacy on a given day were asked to complete a questionnaire regarding the counseling provided by the pharmacist during the visit.Results. More than 90% of patients received advice from the pharmacist on the route of administration, use in relation to meals, dosage and length of treatment. More than 80% of the patients were counseled on the medicine contraindications and precautions, interactions with other medicines and food, side effects, additional changes in lifestyle and diet appropriate to the condition and the necessity to immediately consult a doctor/pharmacist in case of adverse drug reactions. Lower percentages were registered for advising the patient on the obligation to return to pharmacy the unused psychotropic drugs (38.04%) and the ability of the drug to modify the laboratory results (47.66).Conclusions. The results of the present study showed that the counseling activity in the community pharmacy is carried out by the pharmacists in a high proportion, according to the patients’ feedback.

Pharmacy student driven detection of adverse drug reactions in the community pharmacy setting

2010 ◽  
Vol 20 (4) ◽  
pp. 399-404 ◽  
Author(s):  
Søren Troels Christensen ◽  
Birthe Søndergaard ◽  
Per Hartvig Honoré ◽  
Ole Jannik Bjerrum
Keyword(s):  
Community Pharmacy ◽  
Adverse Drug Reactions ◽  
Pharmacy Student ◽  
Drug Reactions ◽  
Pharmacy Setting

scholarly journals Cutaneous adverse drug reactions to psychotropic drugs and their risk factors – a case-control study

2019 ◽  
Vol 29 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Waldemar Greil ◽  
Xueqiong Zhang ◽  
Hans Stassen ◽  
Renate Grohmann ◽  
René Bridler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Case Control Study ◽  
Case Control ◽  
Drug Reactions ◽  
Control Study

scholarly journals Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2109 ◽  
Author(s):  
Muaed Alomar ◽  
Subish Palaian ◽  
Moawia M. Al-tabakha
Keyword(s):  
Data Mining ◽  
Information Technology ◽  
Side Effects ◽  
Adverse Drug Reactions ◽  
Policy Implications ◽  
Policy Framework ◽  
Drug Reactions ◽  
Drug Withdrawals

Considering that marketed drugs are not free from side effects, many countries have initiated pharmacovigilance programs. These initiatives have provided countries with methods of detection and prevention of adverse drug reactions at an earlier stage, thus preventing harm occurring in the larger population. In this review, examples of drug withdrawals due to effective pharmacovigilance programs have been provided with details. In addition, information concerning data mining in pharmacovigilance, an effective method to assess pharmacoepidemiologic data and detecting signals for rare and uncommon side effects, is also examined, which is a method synchronized with information technology and advanced electronic tools. The importance of policy framework in relation to pharmacovigilance is discussed in detail, and country experiences upon implementation of pharmacovigilance policies is highlighted.

Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals

2020 ◽  
Vol 53 (03) ◽  
pp. 133-137
Author(s):  
Julia C. Stingl ◽  
Katja S. Just ◽  
Marlen Schurig ◽  
Miriam Böhme ◽  
Michael Steffens ◽  
...  
Keyword(s):  
Older Adults ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Drug Users ◽  
Prospective Observational Study ◽  
Drug Reactions ◽  
Specific Patient ◽  
Psychotropic Drug Use

Abstract Introduction The prevalence of psychotropic drug use in our society is increasing especially in older adults, thereby provoking severe adverse drug reactions (ADR). To identify specific patient risk profiles associated with psychotropic drug use in the situation of polymedication. Methods Cases of ADRs in general emergency departments (ED) collected within the multi-center prospective observational study (ADRED) were analyzed (n=2215). We compared cases with use of psychotropic drugs and without concerning their clinical presentation at the ED. Results A third of patients (n=731, 33%) presenting to the ED with an ADR took at least 1 psychotropic drug. Patients with psychotropic drug use tended to be older, more often female, and took a higher number of drugs (all p<0.001). The frequency of falls was almost 3 times higher than compared to the non-psychotropic drug group (10.5 vs. 3.9%, p<0.001), and similar syncope was also more often seen in the psychotropic drug users (8.8 vs. 5.5%, p=0.004). The use of psychotropic drugs increased the risk for falls by a factor of 2.82 (OR, 95% CI (1.90–4.18)), when adjusting for gender, age, numbers of pre-existing diseases, and drugs, respectively. Discussion The association of psychotropic drug use with fall and syncope in combination with polymedication and older age leads to the suspicion that psychotropic drugs might be potentially harmful in specific risk populations such as older adults. It may lead us to thoroughly weigh the benefit against risk in a patient-oriented way, leading to an integrative personalized therapy approach.

TOXICITIES OF TARGETED THERAPY AND IMMUNE-RELATED ADVERSE DRUG REACTIONS OF IMMUNOTHERAPY IN THE TREATMENT OF METASTATIC MELANOMA

2018 ◽  
Author(s):  
Lidija Kandolf Sekulović
Keyword(s):  
Overall Survival ◽  
Targeted Therapy ◽  
Side Effects ◽  
Adverse Effects ◽  
Metastatic Melanoma ◽  
Adverse Drug Reactions ◽  
Mek Inhibitor ◽  
Braf Inhibitors ◽  
Drug Reactions ◽  
Acneiform Eruption

Targeted therapy and immunotherapy changed the treatment landscape for metastatic melanoma, which is chemotherapy resistant cancer. In pre-innovation era, the overall survival of patients with metastatic melanoma was 6 months, while today 5-year overall survival rate of 34% (and 50% in good prognostic groups) is evident. However, both treatments have their side effects, and cutaneous are the most frequent. Treating physicians in oncology centres, but also primary care specialists, need to be aware of their spectrum which differs for each class of drug: BRAF inhibitors, MEK inhibitors and immunotherapy with anti-PD1 and anti-CTLA4. While BRAF inhibitors have the most prominent adverse effects which are class specific, there are also drug-specific adverse effects. For example, vemurafenib causes photosensitivity, which is not specific for dabrafenib, while dabrafenib induces pyrexia, that occurs much less frequently with other BRAF inhibitors. Cutaneous rash and cutaneous neoplasms which develop due to paradoxical activation of RAS signalling are described with BRAF inhibitor monotherapy. These side-effects are much less common in combination therapy with BRAF and MEK inhibitor, but MEK inhibitor itself causes characteristic acneiform eruption, and serous retinopathy. Immune related adverse drug reactions are a hallmark of the immune checkpoint inhibitor immunotherapy, which can affect every organ system, and most commonly skin, lungs and gastrointestinal system, with differential frequencies recorded with anti-CTLA4 therapy and anti PD-1 therapy. Skin reactions most frequently include pruritus and eczematous reactions, as well as vitiligo-like hypopigmentation, which is linked Melanom 45 to the better response to treatment. In this review, frequent and rare side effects are presented, as well as the current algorithms for their treatment.

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