scholarly journals DIFFERENT FEATURES OF CHANGES IN CENTRAL HEMODYNAMICS DURING EARLY RECOVERY AFTER DIFFERENT EXERCISE REGIMES

2021 ◽  
Vol 67 (6) ◽  
pp. 13-20
Author(s):  
O.M. Bakunovsky ◽  
◽  
H.V. Lukyantseva ◽  
S.S. Malyuga ◽  
L.T. Kotlyarenko ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Blood Flow ◽  
Dynamic Load ◽  
Static Load ◽  
Recovery Period ◽  
Central Hemodynamics ◽  
Active Muscle ◽  
Early Recovery ◽  
Early Recovery Period

We studied the changes in central hemodynamics in the early recovery period after physical load in 28 young men. Dynamic loading was induced using a modified Martine functional test, static loading - by maintaining on the standing dynamometer DS-200 muscle effort in the amount of 50% of maximum standing force. The change in central hemodynamic para- meters was recorded by tetrapolar thoracic impedance rheo- plethysmogram using a computerized diagnostic complex «Cardio +». Dynamic exercise during early recovery did not lead to a significant increase in heart rate, however, it caused a decrease in the resistance of resistive blood vessels and an increase in pulse blood pressure. The increase in minute blood volume in our study is mainly due to an increase in stroke volume, pointing for high functional reserves of the heart. In the case of static physical activity, the adaptive reactions of central hemodynamics and the course of the processes of early recovery of the circulatory system are radically different from similar indicators during dynamic physical activity. In subjects with a normodynamic type of response of the cardiovascular system to dynamic load, no significant changes in the minute volume of blood flow were registered at a similar volume of active muscle mass static load. In subjects with a normodynamic type of cardiovascular response to dynamic load, no significant changes in cardiac output were observed at a similar static load in terms of active muscle mass. However, during early recovery period, the total peripheral vascular resistance and systolic arterial pressure were increased. The increase in total peripheral resistance may be due to reactive hyperemia in ischemic skeletal muscle caused by increased blood flow to the capillaries after muscle relaxation and delayed outflow into the veins. The significant increase in systolic blood pressure can be explained by the mechanical obstruction of blood flow in the muscle capillaries during prolonged static contraction.

scholarly journals Comparative characteristics of changes in central hemodynamics during early recovery after different exercise regimes

2021 ◽  
Vol 27 (2) ◽  
pp. 47-52
Author(s):  
H.V. Lukyantseva ◽  
O.M. Bakunovsky ◽  
S.S. Malyuga ◽  
T.M. Oliinyk ◽  
N.R. Manchenko ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Dynamic Loading ◽  
Vascular Resistance ◽  
Dynamic Load ◽  
Static Loading ◽  
Circulatory System ◽  
The Body ◽  
Central Hemodynamics ◽  
Early Recovery

The cardiovascular system is one of the most important functional systems of the body, which determine the level of physical performance of the body. Insufficient study of the response of the circulatory system to the combination of strength training with endurance exercises requires more detailed comparative studies of the impact of dynamic and static loads on the indicators of central hemodynamics. Accordingly, the aim of our study was to study the characteristics of the reaction of the cardiovascular system in the period of early recovery after dosed exercise of a dynamic and static nature. The study examined the response of the central hemodynamics of young men in the period of early recovery after dynamic loading (Martine functional test) and static loading (holding on the stand dynamometer DS-200 force with a power of 50% of maximum standing force). The change in circulatory system parameters was recorded using a tetrapolar thoracic impedance rheoplethysmogram on a computerized diagnostic complex “Cardio +”. It is established that the dynamic load in the period of early recovery does not cause a significant positive chronotropic effect, leads to a decrease in vascular resistance of blood flow, to an increase in pulse blood pressure. The increase in cardiac output is mainly due to the increase in stroke volume, which indicates a fairly high functional reserves of the heart. It is revealed that under conditions of static loading the reaction of central hemodynamics and the course of early recovery are radically different from the changes of indicators under dynamic loading. In persons with a normodynamic type of reaction to dynamic load, there are no significant changes in the minute volume of blood at a similar volume of active muscle mass static load. Meeting the metabolic needs of working skeletal muscles and compensating for the oxygen debt is realized by increasing the total peripheral vascular resistance and increasing systolic blood pressure in the postpartum period. The physiological meaning of this phenomenon is to maintain a sufficient level of venous return of blood to ensure the pumping function of the heart.

scholarly journals Effects of Cerebroprotective Agents on Cerebral Blood Flow and on Postischemic Energy Metabolism in the Rat Brain

1987 ◽  
Vol 7 (4) ◽  
pp. 480-488 ◽  
Author(s):  
Gerhard Wilhelm Bielenberg ◽  
Thomas Beck ◽  
Dirk Sauer ◽  
Marta Burniol ◽  
Josef Krieglstein
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Energy Metabolism ◽  
Glucose Level ◽  
Recovery Period ◽  
High Energy ◽  
High Energy Phosphates ◽  
Early Recovery ◽  
Conscious Rat

Male Wistar rats were subjected to forebrain ischemia of 10 min duration by clamping both common carotid arteries and simultaneously lowering systemic blood pressure to 40 mm Hg by exsanguination. Recovery was achieved by removing the arterial clamps and reinfusing the blood. Cortical levels of high-energy phosphates and glycolytic substrates were determined enzymatically. Naftidrofuryl (10 or 20 mg/kg i.p.) or ketamine (5 mg/kg i.v.) were applied 30 min prior to the induction of ischemia. S(-)-Emopamil (4 mg/kg) or nimodipine (50 μg/kg) were administered by intravenous infusion over 30 min. Nimodipine and emopamil increased the blood glucose level and lowered preischemic blood pressure. Under control conditions, a tendency toward a higher cortical glucose level was observed in treated brains. Brain energy stores were exhausted after ischemia in control and treated animals to the same degree. Lactate levels, however, were higher in emopamil-treated animals. This effect was attributed to the elevated pre-ischemic glucose levels. During the early recovery period, the restoration of high-energy phosphates was accelerated by both calcium entry blockers. Nimodipine and emopamil increased the levels of glucose and glucoses-phosphate in the early postischemic period. Naftidrofuryl (10 mg/kg) increased the level of creatine-phosphate and ATP after 2 min of recovery. Naftidrofuryl (20 mg/kg) exerted no effect on cerebral energy metabolism, but considerably reduced postischemic blood pressure (possibly thereby masking its ameliorative action). Ketamine accelerated the postischemic restoration of high-energy phosphates. In the conscious rat, local cerebral blood flow (LCBF) was determined with the 14C-iodoantipyrine technique following emopamil (20 mg/kg s.c.) or naftidrofuryl (10 mg/kg i.v.) application. Both compounds increased LCBF values in the majority of grey matter structures. It was concluded that the cerebroprotective agents investigated share an accelerating effect on the postischemic restoration of high-energy phosphates in cerebral cortex.

Patterns of development of insomnia in patients with early recovery period of stroke

2019 ◽  
Vol 17 (7) ◽  
pp. 95-99
Author(s):  
O. V. Kurushina ◽  
◽  
E. A. Kurakova ◽  
Keyword(s):  
Recovery Period ◽  
Early Recovery ◽  
Early Recovery Period

Opportunities of ultrasound diagnostics of lung injury in SARS-CoV-2 infection (COVID-19): a clinical case

2020 ◽  
Vol 98 (11) ◽  
pp. 51-56
Author(s):  
G. V. Neklyudova ◽  
А. V. Chernyak ◽  
N. А. Tsareva ◽  
S. N. Аvdeev
Keyword(s):  
Lung Injury ◽  
Clinical Case ◽  
Ultrasound Examination ◽  
Recovery Period ◽  
Early Recovery ◽  
Acute Period ◽  
Ultrasound Diagnostics ◽  
Early Recovery Period

The article describes a clinical case demonstrating the results of the lungs ultrasound examination in the COVID-19 patient during the acute period of the disease and early recovery period.

Neurorehabilitation in the Early Recovery Period of Ischemic Stroke. Pharmacology Support

2021 ◽  
Vol 63 (1) ◽  
pp. 22-25
Author(s):  
Denys N. Khramtsov ◽  
Olexandr N. Stoyanov ◽  
Tetiana N. Muratova ◽  
Olexandr R. Pulyk
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Recovery Period ◽  
Rehabilitation Medicine ◽  
Neuroprotective Agents ◽  
Early Recovery ◽  
National Medical ◽  
Cholinergic Agents ◽  
Early Recovery Period ◽  
Medical University

Aim: The aim of the study was to evaluate the clinical outcome in the use of neuroprotective agents in the acute period of ischemic stroke. Material and Methods: The study was performed on the basis of the stroke of the Center for Reconstructive and Rehabilitation Medicine (University Clinic) of the Odessa National Medical University. A retrospective analysis of clinical outcomes of 115 patients with acute stroke was conducted. Results: An average NIHSS score at discharge was 4.1±0.1 points when treated with no refinery, then it reached 3.6±0.1 points when using peptidergic drugs, and 3.4±0.1 when using D-fdf. 3.1±0.1 points. When using D-FDF, the MMSE score was 3.5±0.1 points, whereas when using cholinergic agents, this index did not exceed 26.9±1.5 points, and when using peptidergic agents - 26.8±1.4 points. Conclusion: The use of neuroprotective agents positively affects the effectiveness of neuro-rehabilitation in patients with acute stroke. The best results in three months after the hospitalization were obtained for peptidergic agents and D-fructose-1,6-diphosphate.

Timed synchronization of muscle contraction to heartbeat enhances muscle hyperemia

2020 ◽  
Vol 128 (4) ◽  
pp. 805-812
Author(s):  
Gaia Giuriato ◽  
Stephen J. Ives ◽  
Cantor Tarperi ◽  
Lorenzo Bortolan ◽  
Federico Ruzzante ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Contraction ◽  
Blood Velocity ◽  
Muscle Contractions ◽  
Velocity Spectrum ◽  
Functional Hyperemia ◽  
Central Hemodynamics ◽  
Active Muscle ◽  
Vascular Conductance ◽  
Significant Difference

Blood flow (BF) to exercising muscles is susceptible to variations of intensity, and duration of skeletal muscle contractions, cardiac cycle, blood velocity, and vessel dilation. During cyclic muscle activity, these elements may change proportionally with or without direct optimal temporal alignment, likely influencing BF to active muscle. Ideally, the pulsed delivery of blood to active muscle timed with the inactive phase of muscle duty-cycle would enhance the peak and average BF. To investigate the phenomenon of muscle contraction and pulse synchronicity, electrically evoked muscle contractions (trains of 20 Hz, 200-ms duration) were synchronized with each systolic phase of the anterograde blood velocity spectrum (aBVS). Specifically, unilateral quadriceps contractions matched in-phase (IP) with the aBVS were compared with contractions matched out-of-phase (OP) with the aBVS in 10 healthy participants (26 ± 3 yr). During each trial, femoral BF of the contracting limb and central hemodynamics were recorded for 5 min with an ultrasound Doppler, a plethysmograph, and a cardioimpedance device. At steady state (5th min) IP BF (454 ± 30 mL/min) and vascular conductance (4.3 ± 0.2 mL·min−1·mmHg−1), and OP MAP (108 ± 2 mmHg) were significantly lower ( P < 0.001) in comparison to OP BF (784 ± 25 mL/min) and vascular conductance (6.7 ± 0.2 mL·min−1·mmHg−1), and IP MAP (113 ± 3 mmHg). On the contrary, no significant difference (all, P > 0.05) was observed between IP and OP central hemodynamics (HR: 79 ± 10 vs. 76 ± 11 bpm, CO: 8.0 ± 1.6 vs. 7.3 ± 1.6 L/min), and ventilatory patterns (V̇e:14 ± 2 vs. 14 ± 1 L/min, V̇o2:421 ± 70 vs. 397 ± 34 mL/min). The results suggest that muscle contractions occurring during OP that do not interfere with aBVS elicit a maximization of muscle functional hyperemia. NEW & NOTEWORTHY When muscle contraction is synchronized with the pulsed delivery of blood flow to active muscle, muscle functional hyperemia can be either maximized or minimized. This suggests a possibility to couple different strategies to enhance the acute and chronic effects of exercise on the cardiovascular system.

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