KAPOSI'S VARICELLIFORM ERUPTION; A PRIMARY INFECTION WITH HERPES SIMPLEX VIRUS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (3) ◽  
pp. 364-371
Author(s):  
ISAAC RUCHMAN ◽  
KATHARINE DODD
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Acute Phase ◽  
Primary Infection ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Control Serum ◽  
Corroborative Evidence ◽  
Neutralization Index ◽  
Simplex Virus

Five cases of Kaposi's varicelliform eruption are reported of which three were children and two were adults. The patients had been exposed to one or more members of the immediate family who had herpes simplex infection. The virus of herpes simplex was recovered from two children and one adult. In all five cases the neutralization index of their sera against herpes virus, little higher than that of control serum during the acute phase of their illness, rose during convalescence. Corroborative evidence is obtained from a study of the above cases that Kaposi's varicelliform eruption is in all probability a manifestation of primary infection with herpes simplex virus in persons with eczema.

scholarly journals Herpes simplex infection as a risk factor for dental caries progression

2012 ◽  
Vol 93 (6) ◽  
pp. 896-899
Author(s):  
J V Andreeva ◽  
A I Bulgakova ◽  
I V Valeev
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Main Group ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Diagnodent Pen ◽  
Caries Progression ◽  
Simplex Virus

Aim. To determine the individual risk of caries debut and specific features of the primary caries in patients infected with herpes simplex virus. Methods. 51 patients with primary caries (112 teeth), ICD-10 diagnosis K02.0 (Caries limited to enamel) aged 18 to 49 (female - 42) were examined, all patients were divided into two groups: patients infected with herpes simplex virus and with clinical symptoms of herpes simplex infection (main group, 33 patients), patients infected with herpes simplex virus and without any clinical symptoms of herpes simplex infection (comparison group, 18 patients). Clinical, biochemical, immunological, laser (laser fluorescence spectroscopy) diagnostic techniques were applied. Results. High titers of blood immunoglobulin G to herpes simplex virus were found in 98% of patients examined with initial caries (K02.0). The medium risk was defined in 45% of patients of the main group and in 44% of the comparison group. The navy blue indicator color was the sign of the high risk in 49% in the control group and in 50% of the comparison group. Among the patients with high risk of caries debut the mean local enamel demineralization value according to DIAGNOdent pen was 11.5±1.6 (main group) versus 7.2±1.2 (comparison group). Conclusions. The risk of further caries progression in patients with clinical manifestations of herpes simplex infection is higher compared to patients with persistent infection without signs of active virus reproduction. Biochemical rapid test Clinpro Cario L-Pop (3M ESPE) helps to obtain objective data on oral microflora activity. The use of KaVo «DIAGNOdent pen» device is necessary for the further monitoring of caries progression.

In Reply: ? Herpes Simplex Virus in Breast Milk

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 391-391
Author(s):  
Lisa M. Dunkle ◽  
Rose Rita Schmidt ◽  
Dennis M. O'Connor
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Breast Milk ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Potential Possibility ◽  
The Stability ◽  
Simplex Virus ◽  
Breast Fed

We appreciate Dr. Kibrick's delineation of the stability and infectivity of herpes simplex virus in various media. The remainder of his comments concur with our conclusions and reiterate the potential possibility of risk of herpes simplex infection to some breast-fed infants. The problem would appear to deserve investigation.

scholarly journals CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

2011 ◽  
Vol 85 (19) ◽  
pp. 9945-9955 ◽  
Author(s):  
S. J. Allen ◽  
K. R. Mott ◽  
A. A. Chentoufi ◽  
L. BenMohamed ◽  
S. L. Wechsler ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

Lymphoproliferative and Serological Responses to Herpes Simplex Virus During Primary Infection, Recrudescence, and Re-Infection in a Murine Model

1989 ◽  
Vol 2 (2) ◽  
pp. 115-126 ◽  
Author(s):  
J.P. MAINGAY ◽  
S.E.M. HOWIE ◽  
M. NORVAL ◽  
A.M. MOODYCLIFFE ◽  
W.A. NEILL
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Murine Model ◽  
Primary Infection ◽  
Simplex Virus

The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection

Microbiology ◽  
2000 ◽  
Vol 81 (7) ◽  
pp. 1763-1771 ◽  
Author(s):  
Tatsuo Suzutani ◽  
Masayoshi Nagamine ◽  
Taiichiro Shibaki ◽  
Masahiro Ogasawara ◽  
Itsuro Yoshida ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Interferon Α ◽  
Defence Mechanisms ◽  
Specific Host ◽  
Γ Ray ◽  
Simplex Virus

The UL41 gene product (vhs) of herpes simplex virus (HSV) is packaged in the virion, and mediates host protein synthesis shutoff at the early stage of the virus replication cycle. In order to clarify the role of vhs in virus replication and virulence, we isolated a completely UL41-deficient mutant (the VRΔ41 strain) and its revertant (the VRΔ41R strain). In the mouse encephalitis model, the replication of strain VRΔ41 was inhibited after 2 days post-infection, resulting in low virulence, by γ-ray-sensitive cells such as lymphocytes and/or neutrophils. The result suggested that some cytokines, produced in VRΔ41-inoculated brains, activate and induce the migration of γ-ray-sensitive cells to the infection site. Therefore, cytokines produced by HSV-1-infected human cells were screened, and potent inductions of interleukin (IL)-1β, IL-8 and macrophage inflammatory protein-1α by VRΔ41 infection were observed. Moreover, the VRΔ41 strain showed 20- and 5-fold higher sensitivity to interferon-α and -β compared to the wild-type strain, respectively. These results indicate that one important role of vhs in vivo is evasion from non-specific host defence mechanisms during primary infection through suppression of cytokine production in HSV-infected cells and reduction of the anti-HSV activity of interferon-α and -β.

scholarly journals Disseminated Herpes Simplex Virus Type 1 Primary Infection in a Healthy Individual

2009 ◽  
Vol 20 (4) ◽  
pp. 122-125 ◽  
Author(s):  
Guy Boivin ◽  
Brigitte Malette ◽  
Nathalie Goyette
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Primary Infection ◽  
Polymerase Chain Reaction Detection ◽  
Chain Reaction ◽  
Detection Techniques ◽  
Polymerase Chain ◽  
Simplex Virus ◽  
Hsv 1

BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region.OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man.RESULTS: Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain.CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.

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