scholarly journals Herpes simplex infection as a risk factor for dental caries progression

2012 ◽  
Vol 93 (6) ◽  
pp. 896-899
Author(s):  
J V Andreeva ◽  
A I Bulgakova ◽  
I V Valeev
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Main Group ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Diagnodent Pen ◽  
Caries Progression ◽  
Simplex Virus

Aim. To determine the individual risk of caries debut and specific features of the primary caries in patients infected with herpes simplex virus. Methods. 51 patients with primary caries (112 teeth), ICD-10 diagnosis K02.0 (Caries limited to enamel) aged 18 to 49 (female - 42) were examined, all patients were divided into two groups: patients infected with herpes simplex virus and with clinical symptoms of herpes simplex infection (main group, 33 patients), patients infected with herpes simplex virus and without any clinical symptoms of herpes simplex infection (comparison group, 18 patients). Clinical, biochemical, immunological, laser (laser fluorescence spectroscopy) diagnostic techniques were applied. Results. High titers of blood immunoglobulin G to herpes simplex virus were found in 98% of patients examined with initial caries (K02.0). The medium risk was defined in 45% of patients of the main group and in 44% of the comparison group. The navy blue indicator color was the sign of the high risk in 49% in the control group and in 50% of the comparison group. Among the patients with high risk of caries debut the mean local enamel demineralization value according to DIAGNOdent pen was 11.5±1.6 (main group) versus 7.2±1.2 (comparison group). Conclusions. The risk of further caries progression in patients with clinical manifestations of herpes simplex infection is higher compared to patients with persistent infection without signs of active virus reproduction. Biochemical rapid test Clinpro Cario L-Pop (3M ESPE) helps to obtain objective data on oral microflora activity. The use of KaVo «DIAGNOdent pen» device is necessary for the further monitoring of caries progression.

KAPOSI'S VARICELLIFORM ERUPTION; A PRIMARY INFECTION WITH HERPES SIMPLEX VIRUS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (3) ◽  
pp. 364-371
Author(s):  
ISAAC RUCHMAN ◽  
KATHARINE DODD
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Acute Phase ◽  
Primary Infection ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Control Serum ◽  
Corroborative Evidence ◽  
Neutralization Index ◽  
Simplex Virus

Five cases of Kaposi's varicelliform eruption are reported of which three were children and two were adults. The patients had been exposed to one or more members of the immediate family who had herpes simplex infection. The virus of herpes simplex was recovered from two children and one adult. In all five cases the neutralization index of their sera against herpes virus, little higher than that of control serum during the acute phase of their illness, rose during convalescence. Corroborative evidence is obtained from a study of the above cases that Kaposi's varicelliform eruption is in all probability a manifestation of primary infection with herpes simplex virus in persons with eczema.

In Reply: ? Herpes Simplex Virus in Breast Milk

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 391-391
Author(s):  
Lisa M. Dunkle ◽  
Rose Rita Schmidt ◽  
Dennis M. O'Connor
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Breast Milk ◽  
Herpes Simplex Infection ◽  
Simplex Infection ◽  
Potential Possibility ◽  
The Stability ◽  
Simplex Virus ◽  
Breast Fed

We appreciate Dr. Kibrick's delineation of the stability and infectivity of herpes simplex virus in various media. The remainder of his comments concur with our conclusions and reiterate the potential possibility of risk of herpes simplex infection to some breast-fed infants. The problem would appear to deserve investigation.

scholarly journals What is the True Etiology of “Recurrent Shingles”?

2021 ◽  
Vol 5 (1) ◽  
pp. 7-12
Author(s):  
Ramya Vangipuram ◽  
Harrison Nguyen ◽  
Stephen Tyring
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Varicella Zoster ◽  
Dermatology Clinic ◽  
Simplex Infection ◽  
Common Diagnosis ◽  
Recurrent Herpes ◽  
Simplex Virus

Purpose:  To determine the true etiology of cases of putative recurrent shingles referred to a dermatology clinic. Methods: A prospective cohort study of patients aged 15-87 years with reported recurrent herpes zoster was conducted. Vesicular fluid and serology for herpes simplex 1, 2, and varicella zoster virus immunoglobulins were obtained from patients presenting with vesicles. Biopsies were obtained from patients with ambiguous presentations. Results:  44 patients (56%) had evidence of herpes simplex virus infection. 32% of patients had positive herpes simplex virus cultures or polymerase chain reaction sequencing, and 24% additional patients were diagnosed with presumptive simplex infection based on elevated antibody titers. 44% of patients had a diagnosis other than zoster or simplex. One individual had a positive viral culture for varicella zoster virus. 99% of patients who presented with suspected recurrent herpes zoster had no definitive evidence of varicella zoster virus reactivation. Conclusions:  The most common diagnosis was herpes simplex infection. Our results suggest that true recurrent shingles in immunocompetent patients is rare.

scholarly journals SR-2P Vaginal Microbicide Gel Provides Protection against Herpes Simplex Virus 2 When Administered as a Combined Prophylactic and Postexposure Therapeutic

2015 ◽  
Vol 59 (9) ◽  
pp. 5697-5704 ◽  
Author(s):  
Scott A. Fields ◽  
Gaurav Bhatia ◽  
Julie M. Fong ◽  
Mingtao Liu ◽  
Gita N. Shankar
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Body Weight Loss ◽  
Clinical Score ◽  
Lethal Challenge ◽  
Prophylactic Dose ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

ABSTRACTPreviously, we demonstrated that a single prophylactic dose of SR-2P, a novel dual-component microbicide gel comprising acyclovir and tenofovir, led to a modest increase in mouse survival following a lethal challenge of herpes simplex virus 2 (HSV-2). Here, we show that a dose of SR-2P administered 24 h prior to infection provides some protection against the virus, but to a lesser degree than SR-2P administered either once a day for 2 days or 1 h prior to infection. None of the prophylactic doses blocked infection by the virus, and all resulted in 80 to 100% lethality. However, given that a prophylactic dose still provided a significant reduction in overall clinical score, reduced rate of body weight loss, and increased median survival of the mice, we examined whether a repetitive dose regimen (postinfection) in addition to the prophylactic dose could prevent death and reduce the levels of virus in mice. Nearly all (9 of 10 in each group) of the mice that received SR-2P for 2 days prior to infection or that received SR-2P 1 h prior to infection and were administered SR-2P once a day for 10 days after infection showed no clinical symptoms of infection and no viral loads in vaginal swabs and survived for 28 days postinfection. Conversely, mice receiving no treatment or an identical vehicle treatment demonstrated advanced clinical signs and did not survive past day 9 postinfection. We conclude that SR-2P is an effective anti-HSV-2 agent in mice.

Neonatal Herpes Simplex Infection Possibly Acquired via Maternal Breast Milk

PEDIATRICS ◽  
1979 ◽  
Vol 63 (2) ◽  
pp. 250-251
Author(s):  
Lisa M. Dunkle ◽  
Rose Rita Schmidt ◽  
Dennis M. O'Connor
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Breast Milk ◽  
Neonatal Herpes ◽  
Simplex Infection ◽  
History Of ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus ◽  
Hsv 1

A newborn infant with disseminated herpes simplex virus type 1 (HSV-1) infection was determined serologicallv to have acquired the infection postnatally; his mother was found to have HSV-1 in her breast milk but had no history of genital lesions and negative viral cultures of cervix, vagina, and throat. We suggest that HSV-infected maternal breast milk may be a source of this infection for susceptible infants.

scholarly journals Evaluation of a Novel, Anti-Herpes Simplex Virus Compound, Acyclovir Elaidate (P-4010), in the Female Guinea Pig Model of Genital Herpes

1999 ◽  
Vol 43 (1) ◽  
pp. 53-61 ◽  
Author(s):  
R. Jennings ◽  
T. L. Smith ◽  
F. Myhren ◽  
J. Phillips ◽  
M. L. Sandvold
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Guinea Pig ◽  
Genital Herpes ◽  
Clinical Symptoms ◽  
Pig Model ◽  
Oral Gavage ◽  
Recurrent Genital Herpes ◽  
Guinea Pig Model ◽  
Simplex Virus

ABSTRACT The antiviral effect of acyclovir elaidate in the female guinea pig model of genital herpes was investigated in a series of experiments. The antiherpesvirus effects of this novel compound, 9-(2′-[trans-9"-octadecenoyloxyl]ethoxymethyl)guanine (code no. P-4010), were studied in both primary and recurrent genital herpes in the female guinea pig, following oral gavage or intraperitoneal injection, with different formulations of the compound, and in comparison with acyclovir (ACV) or penciclovir (PCV). The results indicate that compound P-4010 has a greater capability than either ACV or PCV in reducing the clinical symptoms of primary genital herpes induced following the inoculation of herpes simplex virus type 2 (HSV-2) intravaginally into guinea pigs. In addition, the administration of P-4010 twice daily over a 10-day period by the intraperitoneal route (15 to 40 mg/kg of body weight/day) or by oral gavage (50 to 200 mg/kg/day), commencing 4 h subsequent to intravaginal HSV-2 infection, resulted in a degree of reduction in the incidence and severity of spontaneous, recurrent genital herpes in these animals. The findings are discussed in the light of the value and relevance of the female guinea pig model of genital herpes for the assessment of anti-herpes simplex virus compounds.

scholarly journals Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers

2002 ◽  
Vol 76 (7) ◽  
pp. 3502-3510 ◽  
Author(s):  
Kazumi Norose ◽  
Akihiko Yano ◽  
Xiang-Ming Zhang ◽  
Elizabeth Blankenhorn ◽  
Ellen Heber-Katz
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Inflammatory Response ◽  
Disease Susceptibility ◽  
Clinical Symptoms ◽  
Ocular Disease ◽  
Genome Wide ◽  
A Genome ◽  
Herpes Simplex Keratitis ◽  
Simplex Virus

ABSTRACT Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV × C57BL/6)F2 mice were generated and examined for their disease susceptibility in terms of clinical symptoms, ocular disease, and antibody production following corneal scarification with HSV (KOS). A genome-wide screen was carried out using microsatellite markers to determine the genetic loci involved in this response. Loci on chromosomes 4, 5, 12, 13, and 14 were shown to be involved in general susceptibility to clinical disease, whereas loci on chromosomes 10 and 17 were shown to be unique to ocular disease.

Multicentre Clinical Trial with Herpes Simplex Virus Vaccine in Recurrent Herpes Infection

1995 ◽  
Vol 6 (6) ◽  
pp. 431-435 ◽  
Author(s):  
Antonio Mastrolorenzo ◽  
L Tiradritti ◽  
L Salimbeni ◽  
G Zuccati
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Control Group ◽  
Protective Effects ◽  
Oral Acyclovir ◽  
Simplex Infection ◽  
Recurrent Herpes ◽  
Simplex Virus ◽  
Immunological Evaluation ◽  
Active Disease

Summary: The aim of this work was to confirm our preliminary clinical and immunological evaluation of the protective effects of a herpes simplex virus (HSV) vaccine derived from killed virus in the treatment of relapsing facial or genital herpes simplex infection. A total of 142 patients were treated with the HSV vaccine and a control group of 50 were treated with intermittent oral acyclovir (ACV). The vaccine reduced annual active disease days in vaccinees to 11.59 (±15.3) after treatment (65.11±31.64 before treatment) compared to 30.4±17.49 days after treatment of the control group patients (71.86±32.5 before treatment).

scholarly journals Penatalaksanaan infeksi herpes simpleks oral rekuren Management of recurrent oral herpes simplex infection

2013 ◽  
Vol 12 (1) ◽  
pp. 28
Author(s):  
Erni Marlina ◽  
Bagus Soebadi
Keyword(s):  
Herpes Simplex ◽  
Supportive Therapy ◽  
Herpes Simplex Infection ◽  
Virus Reactivation ◽  
Oral Herpes ◽  
Simplex Infection ◽  
Oral Tissue ◽  
Infection Patient ◽  
Simplex Virus ◽  
Tissue Trauma

Recurrent oral herpes simplex infection was the secondary or recurrent form of primary herpes simpex infection. Inhuman, herpes simplex virus was latent or dormant and could reactivate. Recurrency due to virus reactivation inducedby emotional stress, high fever, ultraviolet exposed, oral tissue or neuron tissue trauma, immunosuppresion condition,and hormonal disturbance. The aim of this paper was to report and discuss management of recurrent oral herpessimplex infection which complicated in the diagnosis due to manifestation of both herpes labialis and intraoral lesionform resembling herpes simplex infection. Patient was a 22 years- old woman, came to Installaton of Dental, dr.Soetomo Hospital with chief complaint pain were soreness caused by ulcer on the tongue accompanied by tingling nearthe upper labial mucosal. Patient was prescribed with acyclovir as causative therapy, mouthwash contain extract ofaloe vera, multivitamins and immunomodulator as supportive therapy. Patient healed 4 days after the first visit. It wasconcluded that this case was diagnosed clinically as recurrent oral herpes simplex infections. Causative therapy withacyclovir administration showed excellent response, as well as supportive therapy immunomodulator that supportedimprovement of the immune system so that the frequency of recurrence can be reduced.

Neonatal Herpes Simplex Virus Infection Introduced by Fetal-Monitor Scalp Electrodes

PEDIATRICS ◽  
1980 ◽  
Vol 65 (6) ◽  
pp. 1150-1153 ◽  
Author(s):  
Louis S. Parvey ◽  
Lawrence T. Ch'ien
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Pneumatosis Intestinalis ◽  
Fetal Monitoring ◽  
Neonatal Herpes ◽  
Simplex Infection ◽  
Vesicle Fluid ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus

An infant was severely infected with herpes simplex virus as a result of fetal monitoring with scalp electrodes on the buttocks. The first vesicles appeared at the site where the electrodes had been placed and, by day 9 after birth, additional lesions covered the entire perineum and lower extremities. The child developed acute meningoencephalitis and pneumatosis intestinalis. Herpes simplex virus was isolated from cultures of skin vesicle fluid, cornea, saliva, blood, and spinal fluid. The infection resolved after treatment with adenosine arabinoside, administered intravenously for 11 days and applied topically for another 15 days. A follow-up examination when the child was 2 years old disclosed no physical or neurologic abnormalities. This case illustrates the risk of introducing herpes simplex infection by internal fetal monitoring.

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