SYSTEMIC LUPUS ERYTHEMATOSUS IN CHILDHOOD

PEDIATRICS ◽  
1963 ◽  
Vol 32 (2) ◽  
pp. 257-264
Author(s):  
Jerry C. Jacobs
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Medical Center ◽  
Controlled Study ◽  
Systemic Lupus ◽  
Drug Induced ◽  
History Of

The clinical features of 35 children with systemic lupus erythematosus seen at the Columbia-Presbyterian Medical Center between 1930 and 1961 have been summarized. Seven of the more recent 25 patients gave a history of seizures and treatment with anticonvulsant medicaments prior to the onset of lupus and are believed to represent cases of drug-induced disease. The mechanism whereby drugs induce this disorder in susceptible patients receiving anticonvulsant medicaments remains unknown. While there is little question that steroids have improved the prognosis in systemic lupus erythematosus, further controlled study of varying therapeutic regimens is needed.

Severe hydralazine-induced lupus presenting as systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (5) ◽  
pp. 509-513 ◽  
Author(s):  
R L Rubin ◽  
R F Haluptzok ◽  
L M Davila
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Autoimmune Disease ◽  
Systemic Lupus ◽  
Drug Usage ◽  
Drug Induced ◽  
Disease Etiology ◽  
History Of ◽  
Anti Inflammatory ◽  
Symptoms And Signs

Despite its long history of untoward side effects of a systemic autoimmune disease, drug-induced lupus can be difficult to recognize because of the disconnect between chronic drug usage and onset of symptoms. In this case, the patient was treated with hydralazine for two years when symptoms were initially reported, but a diagnosis of hydralazine-induced lupus was not considered for another half year. Despite treatment with steroidal and nonsteroidal anti-inflammatory medications during this period, rheumatologic symptoms and signs continued to deteriorate, consistent with the diagnosis of systemic lupus erythematosus. Not until the patient voluntarily discontinued hydralazine did symptoms begin to improve, fully resolving over the subsequent 6–12 months largely in the absence of anti-inflammatory medication. This patient demonstrates that failure to recognize a drug-induced disease etiology can result in substantial worsening of rheumatologic symptoms over the subsequent six months, ultimately satisfying criteria for systemic lupus erythematosus. While symptoms and signs largely normalized, some laboratory abnormalities and occasional arthralgia remained two years after discontinuing hydralazine, suggesting smoldering inflammatory disease.

scholarly journals Capecitabine-Induced Subacute Cutaneous Lupus Erythematosus in a Patient with Systemic Lupus Erythematosus

2018 ◽  
Vol 2 (1) ◽  
pp. 59-63
Author(s):  
Alyx Rosen ◽  
Evan Darwin ◽  
Jennifer N Choi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Metastatic Breast ◽  
Subacute Cutaneous Lupus Erythematosus ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Increased Risk ◽  
History Of ◽  
Cutaneous Lupus

Capecitabine is a fluoropyrimidine chemotherapy prodrug of 5-fluorouracil (5-FU) used in the treatment of metastatic breast and colorectal cancers. Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is a rare side effect of capecitabine therapy, with eight cases previously reported. We report a case of DI-SCLE in a patient with a documented history of systemic lupus erythematosus (SLE). This is the second documented case of DI-SCLE in a patient with a past medical history of SLE, and provides evidence that there may be an increased risk of DI-SCLE in these patients. Further research should examine whether patients with SLE are at greater risk for this adverse event. 

Systemic lupus erythematosus

2011 ◽  
pp. 321-341
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus ◽  
Drug Induced

Introduction 322 The clinical features of systemic lupus erythematosus 324 Antiphospholipid (antibody) syndrome and systemic lupus erythematosus 329 Pregnancy and systemic lupus erythematosus 330 Diagnosis and investigation of systemic lupus erythematosus 332 Drug-induced lupus erythematosus 335 The treatment of systemic lupus erythematosus 336 Prognosis and survival in systemic lupus erythematosus ...

scholarly journals Systemic Lupus Erythematosus in a Patient with Ulcerative Colitis: Co-Existing or Drug-Induced?

2019 ◽  
Vol 19 (02) ◽  
pp. 67-69
Author(s):  
Frances Feisi Sun ◽  
Nga Lai Chan ◽  
Tsz Ching Chan ◽  
Ka Long Leung ◽  
Yuk Wo Aaron Siu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Lupus Erythematosus ◽  
Bowel Disease ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Drug History ◽  
History Of ◽  
Inflammatory Bowel

We report a 49-year-old lady with ulcerative colitis (UC) who subsequently developed systemic lupus erythematosus (SLE) ten years later. By reviewing the drug history and serum autoimmune panel, we hypothesize that systemic lupus erythematosus may occur in a patient with a history of inflammatory bowel disease as a coexisting disease, or triggered by drugs used in inflammatory bowel disease, such as disease-modifying anti-rheumatic drugs (DMARDs). This case raises the discussion that patients with Inflammatory bowel disease (IBD) may have a genetic predisposition for developing other autoimmune diseases, and explores the possibility of drugs used in the treatment of IBD as a trigger for SLE development. Being able to differentiate the two has important implications in management and prognosis.

Uncontrollable Seizures in an Epileptic

1977 ◽  
Vol 11 (10) ◽  
pp. 590-594
Author(s):  
John E. Zarek
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Seizure Control ◽  
Underlying Disease ◽  
Blood Levels ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Double Stranded Dna ◽  
History Of ◽  
History Of Epilepsy

A case of possible phenytoin-induced systemic lupus erythematosus is presented in a patient with a twenty-year history of epilepsy. The failure of seizure control in the presence of adequate anticonvulsant blood levels pointed to an underlying disease state. Drug-induced and idiopathic systemic lupus erythematosus are quite similar in clinical and laboratory manifestations. However, antibodies to native (double-stranded)-DNA seem to be consistent with the idiopathic form. A review of drug-induced systemic lupus erythematosus is presented.

Letters to the Editor

PEDIATRICS ◽  
1964 ◽  
Vol 33 (1) ◽  
pp. 144-145
Author(s):  
JERRY C. JACOBS
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Room Temperature ◽  
Signs And Symptoms ◽  
Anticonvulsant Drugs ◽  
Systemic Lupus ◽  
Letters To The Editor ◽  
Drug Induced ◽  
History Of

All of our "drug-induced" patients had signs and symptoms suggestive of systemic lupus erythematosus (SLE), with positive L-E preps done on lightly heparinized blood after a 1-hour incubation at room temperature (a relatively insensitive method). The only differentiating features in these patients were a history of seizures prior to the onset of other manifestations of SLE and treatment with anticonvulsant drugs. The purpose of our paper was to show that such patients, as a group, have a more favorable course than others, providing the offending agent is withdrawn.

scholarly journals Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091002 ◽  
Author(s):  
Umut Selamet ◽  
Ramy M Hanna ◽  
Anthony Sisk ◽  
Lama Abdelnour ◽  
Lena Ghobry ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Interstitial Nephritis ◽  
Lupus Erythematosus ◽  
Kidney Biopsy ◽  
Kidney Injury ◽  
Acute Interstitial Nephritis ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Systemic Manifestations

Drug-induced lupus erythematosus has features distinct from primary systemic lupus erythematosus. It can occur with a wide variety of agents that result in the generation of anti-histone or other types of antibodies. Systemic manifestations of drug-induced systemic lupus erythematosus may include renal dysfunction due to circulating immune complexes or due to other immune reactions to the culprit medication(s). Acute interstitial nephritis occurs due to DNA–drug or protein–drug complexes that trigger an allergic immune response. We report a patient who developed acute kidney injury, rash, and drug-induced systemic lupus diagnosed by serologies after starting chlorthalidone and amiodarone. A renal biopsy showed acute interstitial nephritis and not lupus-induced glomerulonephritis. It is important to note that systemic lupus erythematosus and acute interstitial nephritis can occur together, and this report highlights the role of the kidney biopsy in ascertaining the pathological diagnosis and outlining therapy in drug-induced lupus erythematosus.

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