A TWENTY-FIVE YEAR FOLLOW-UP STUDY ON THE HYPERKINETIC CHILD WITH MINIMAL BRAIN DYSFUNCTION

PEDIATRICS ◽  
1967 ◽  
Vol 39 (3) ◽  
pp. 393-399
Author(s):  
Miriam M. Menkes ◽  
Jane S. Rowe ◽  
John H. Menkes
Keyword(s):  
Brain Dysfunction ◽  
Motor Dysfunction ◽  
Minimal Brain Dysfunction ◽  
Speech Impairment ◽  
Presenting Symptoms ◽  
Follow Up Study ◽  
Short Attention Span ◽  
Hyperkinetic Child ◽  
Visual Motor

Eighteen patients who had been evaluated at a child psychiatry clinic a mean of 24 years ago were selected for follow-up by the following criteria: the presenting symptoms had been hyperactivity and short attention span, none had seizures, all had an I.Q. over 70, and all had indications of neurologic abnormalities such as poor coordination, visual motor dysfunction, or speech impairment. Eleven of the 18 were reexamined fully and an interview or information was obtained about three more. Neurologic examination showed definite abnormalities in eight subjects and suspicious findings in one, but it was normal in two. Hyperactivity was still present in three subjects aged 22 to 23 years and had disappeared between the ages of 8 and 21 in the others. Four subjects were institutionalized as psychotic, two others were retarded and supported by their families, and eight were self-supporting. Of the latter, four have spent some time in institutions. A major prognositc factor was the I.Q. obtained during initial evaluation; all but one of the subjects who were self-supporting had scored an I.Q. above 90.

Effects of a Stimulant Drug on Extra Version Level in Hyperactive Children

1978 ◽  
Vol 46 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Donald L. McManis ◽  
Mike McCarthy ◽  
Randy Koval
Keyword(s):  
Pilot Study ◽  
Vigilance Task ◽  
Lemon Juice ◽  
Reactive Inhibition ◽  
Stimulant Drug ◽  
Follow Up Study ◽  
Hyperactive Children ◽  
Visual Motor

7 hyperactive children in a pilot study, and 15 hyperactive and 15 non-hyperactive control children in a later study, were assessed for salivation to lemon juice stimulation, reactive inhibition on an audio-vigilance task, and visual-motor maze errors. Hyperactive children were tested under stimulant drug and nondrug conditions and nonhyperactive children twice under nondrug conditions. Pilot study hyperactive children displayed significantly fewer maze errors and somewhat greater salivation and lesser reactive inhibition levels under the drug than the nondrug conditions. Follow-up study control children did not differ significantly between test occasions on any measure, while the hyperactive children displayed significantly fewer maze errors, mote salivation, and less reactive inhibition under the stimulant drug, indicating significant decreases in extraversion after the stimulant drug.

scholarly journals Association between Fatigue and Hoehn-Yahr Staging in Parkinson’s Disease: Eight-Year Follow-Up Study

2021 ◽  
Vol 13 (2) ◽  
pp. 224-231
Author(s):  
Hiroshi Kataoka ◽  
Kazuma Sugie
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Disease Progression ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Motor Dysfunction ◽  
Follow Up Study

The severity of Parkinson’s disease (PD) is developed by multifactorial factors. Falls can worsen disease severity. We previously found that frontal assessment battery (FAB) score was associated with a higher risk of future falls. This eight-year follow-up study aimed to verify whether factors including low FAB score can be the risk of PD progression based on the Hoehn and Yahr scale. In total, 95 patients were initially enrolled in this research and 45 were included in the final follow-up. Then, the cohort was classified into patients with and without disease progression, defined by upgrade of Hoehn-Yahr stage. Differences in clinical characteristics between patients with disease progression and those without were evaluated using the Mann–Whitney U test. Eighteen independent variables were evaluated via a univariate logistic regression analysis. Of the 45 patients enrolled, 32 had disease progression and 13 had no progression. Age (p = 0.033), BFI score (p = 0.003), Zung self-rating depression (p = 0.011), and anxiety scale (p = 0.026) were significantly increased in patients who had disease progression than those with no disease progression. On multivariate logistic regression analysis, brief fatigue inventory (BFI) score (OR = 1.048, p = 0.045, 95% CI = 1.001–1.098) was significantly related to disease progression. All BFI subscores related to general fatigue. Fatigue could predict the progression of motor dysfunction severity over a longitudinal duration in patients with PD with disease progression, having declining physical and mental fatigue.

Perceptual-Motor Coordination and Style in Healthy Boys and Those with Minimal Brain Dysfunction

1992 ◽  
Vol 75 (2) ◽  
pp. 448-450
Author(s):  
P. Cakirpaloglu ◽  
T. Radil
Keyword(s):  
Motor Coordination ◽  
Brain Dysfunction ◽  
Target Size ◽  
Minimal Brain Dysfunction ◽  
High Incidence ◽  
Two Measures ◽  
Visual Motor ◽  
Small Targets

Differences in visual-motor tracking by 8- to 9-yr.-old boys diagnosed with Minimal Brain Dysfunction or healthy have been analyzed. The subject's task was to use two computer keys to control a cursor line within a target which moved horizontally in two directions over the display. Target size and speed were the experimental variables. Off-target incidences and durations were measured and evaluated. The latter were longer and the former were more frequent on small targets for boys with brain dysfunction than for healthy boys. The two measures correlated negatively in most situations. The perceptual-motor style expressed by means of the distribution of coincidences of the two measures being over or under a criterion set equal to the corresponding averages of the healthy boys was different in the two groups. Brain-damaged boys were characterized mostly by the combination of high incidence of low duration misses for small and fast targets and by high incidence of high duration misses for large and slow targets, whereas most healthy boys showed a few misses of low duration for large and slow targets and few misses of high duration for small and fast targets.

A Five-Year Follow-Up of Children with Minimal Brain Dysfunction

1975 ◽  
Vol 10 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Linda C. Eaves ◽  
John U. Crichton
Keyword(s):  
Brain Dysfunction ◽  
Minimal Brain Dysfunction

Visual-Motor Tracking by Hyperkinetic Children

1980 ◽  
Vol 51 (2) ◽  
pp. 487-497 ◽  
Author(s):  
C Keith Conners ◽  
Alan Delamater
Keyword(s):  
Drug Sensitivity ◽  
Stimulant Medication ◽  
Psychiatric Inpatients ◽  
Brain Dysfunction ◽  
Drug Action ◽  
Tracking Task ◽  
Minimal Brain Dysfunction ◽  
Stimulant Drug ◽  
Visual Motor ◽  
Normal Controls

Two studies of a visual-motor tracking task purported to be an effective discriminator of subtypes of minimal brain dysfunction are presented. Performances of 16 psychiatric inpatients were compared with those of 14 hyperactive males and of 15 normal controls. A second study evaluated effects of practice and drug sensitivity on tracking. The task discriminated patients from normals but did not discriminate the groups of patients from each other. Interactions of practice, age, and diagnosis were found. Some degree of sensitivity of the task to stimulant medication was also obtained. Visual-motor tracking is a useful measure of stimulant drug action but does not measure a defect specific to hyperkinetic patients.

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