Effects of a Stimulant Drug on Extra Version Level in Hyperactive Children

1978 ◽  
Vol 46 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Donald L. McManis ◽  
Mike McCarthy ◽  
Randy Koval

7 hyperactive children in a pilot study, and 15 hyperactive and 15 non-hyperactive control children in a later study, were assessed for salivation to lemon juice stimulation, reactive inhibition on an audio-vigilance task, and visual-motor maze errors. Hyperactive children were tested under stimulant drug and nondrug conditions and nonhyperactive children twice under nondrug conditions. Pilot study hyperactive children displayed significantly fewer maze errors and somewhat greater salivation and lesser reactive inhibition levels under the drug than the nondrug conditions. Follow-up study control children did not differ significantly between test occasions on any measure, while the hyperactive children displayed significantly fewer maze errors, mote salivation, and less reactive inhibition under the stimulant drug, indicating significant decreases in extraversion after the stimulant drug.

1993 ◽  
Vol 10 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Reint Geuze ◽  
Hannelore Börger

The aim of the present follow-up study was to assess whether clumsiness persists beyond the age of 12 and to describe the characteristics of motor and other problems, if present. From 62 children studied in 1984, 12 clumsy and 14 control children were reassessed in 1989. Reasons for dropout were a change of address, unwillingness to participate, and exclusion of hyperactive children with clumsiness. The Test of Motor Impairment indicated that at least 50% of the clumsy children were still markedly below the level of normal motor performance. This outcome was also validated by parent and teacher opinions. Persistent problems were not specifically related to one domain of fine or gross motor ability or general coordination. Concomitant problems reported by teachers and parents were lack of concentration and problems in social behavior.


2020 ◽  
Vol 58 (2) ◽  
pp. 111-125
Author(s):  
Emaley McCulloch ◽  
Audra Cuckler ◽  
Elise Valdes ◽  
M. Courtney Hughes

Abstract Dysphagia is common in individuals with developmental disabilities. Little research exists on the impact of trainings aimed at improving Direct Care Staff's (DCS) use of safe eating and drinking practices. This article presents two studies using pre-and postexperimental design, evaluating online training to improve DCSs' knowledge and ability to identify nonadherence to diet orders. A pilot study (n = 18) informed improvements to the intervention. The follow-up study (n = 64) compared those receiving training with those receiving training plus supervisor feedback. There was no significant difference between groups after training. Both groups increased in knowledge and identification of nonadherence to diet orders. Online training may be an effective tool for training DCS in safe eating and drinking practices.


2015 ◽  
Vol 60 (2) ◽  
pp. 833-837 ◽  
Author(s):  
María Gabriela Álvarez ◽  
Yolanda Hernández ◽  
Graciela Bertocchi ◽  
Marisa Fernández ◽  
Bruno Lococo ◽  
...  

ABSTRACTThere is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas disease patients. A pilot study with intermittent doses of benznidazole at 5 mg/kg/day in two daily doses every 5 days for a total of 60 days was designed. The main criterion of response was the comparison of quantitative PCR (qPCR) findings prior to and 1 week after the end of treatment. The safety profile was assessed by the rate of suspensions and severity of adverse effects. Twenty patients were analyzed for safety, while qPCR was tested for 17 of them. The average age was 43 ± 7.9 years; 55% were female. Sixty-five percent of treated subjects showed detectable qPCR results prior to treatment of 1.45 (0.63 to 2.81) and 2.1 (1.18 to 2.78) parasitic equivalents per milliliter of blood (par.eq/ml) for kinetoplastic DNA (kDNA) qPCR and nuclear repetitive sequence satellite DNA (SatDNA) qPCR, respectively. One patient showed detectable PCR at the end of treatment (1/17), corresponding to 6% treatment failure, compared with 11/17 (65%) patients pretreatment (P= 0.01). Adverse effects were present in 10/20 (50%) patients, but in only one case was treatment suspended. Eight patients showed mild adverse effects, whereas moderate reactions with increased liver enzymes were observed in two patients. The main accomplishment of this pilot study is the promising low rate of treatment suspension. Intermittent administration of benznidazole emerges a new potential therapeutic scheme, the efficacy of which should be confirmed by long-term assessment posttreatment.


1978 ◽  
Vol 3 (4) ◽  
pp. 188-194 ◽  
Author(s):  
Arthur G. A. Blouin ◽  
Robert A. Bornstein ◽  
Ronald L. Trites

PEDIATRICS ◽  
1967 ◽  
Vol 39 (3) ◽  
pp. 393-399
Author(s):  
Miriam M. Menkes ◽  
Jane S. Rowe ◽  
John H. Menkes

Eighteen patients who had been evaluated at a child psychiatry clinic a mean of 24 years ago were selected for follow-up by the following criteria: the presenting symptoms had been hyperactivity and short attention span, none had seizures, all had an I.Q. over 70, and all had indications of neurologic abnormalities such as poor coordination, visual motor dysfunction, or speech impairment. Eleven of the 18 were reexamined fully and an interview or information was obtained about three more. Neurologic examination showed definite abnormalities in eight subjects and suspicious findings in one, but it was normal in two. Hyperactivity was still present in three subjects aged 22 to 23 years and had disappeared between the ages of 8 and 21 in the others. Four subjects were institutionalized as psychotic, two others were retarded and supported by their families, and eight were self-supporting. Of the latter, four have spent some time in institutions. A major prognositc factor was the I.Q. obtained during initial evaluation; all but one of the subjects who were self-supporting had scored an I.Q. above 90.


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