Prolonged Symptomatic Neonatal Hypoglycemia Associated with Maternal Chlorpropamide Therapy

PEDIATRICS ◽  
1968 ◽  
Vol 42 (5) ◽  
pp. 824-825
Author(s):  
Preston Zucker ◽  
Gilbert Simon
Keyword(s):  
Case Report ◽  
Cesarean Section ◽  
Blood Sugar ◽  
White Male ◽  
Neonatal Hypoglycemia ◽  
Infants Of Diabetic Mothers ◽  
Repeat Cesarean Section ◽  
Diabetic Mothers

Ordinarily, the hypoglycemia of infants of diabetic mothers is brief and asymptomatic.1 It is considered to result from fetal hyperinsulinism secondary to prenatal hyperglycemia. The infant described below had prolonged symptomatic hypoglycemia associated with maternal chlorpropamide (Diabinese) therapy. Case Report The patient, a 3,715 gm white male, was the product of a 37-week gestation of a gravida 3, para 2, A positive, 36-year-old mother by repeat cesarean section. The mother, a mild diabetic since age 31, had been receiving 250 mg chlorpropamide twice daily, including the morning of her delivery. The infant's blood sugar was 20 mg/100 ml at 4 hours of age, and he was then transferred to Babies Hospital for further care.

STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT

PEDIATRICS ◽  
1961 ◽  
Vol 28 (4) ◽  
pp. 592-601
Author(s):  
Marvin Cornblath ◽  
Demetrios Nicolopoulos ◽  
Angelita F. Ganzon ◽  
Ephraim Y. Levin ◽  
Mordecai H. Gordon ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Newborn Infant ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Glucagon in varying doses was given to 40 infants born to diabetic mothers, and the blood sugar concentrations were determined at intervals thereafter. Glucagon (30 µg/kg) produced a hyperglycemia in vaginally delivered infants but not in those delivered by cesarean section. Glucagon (300 µg/kg) produced a hyperglycemia in infants delivered by cesarean section. Distressed infants seemed to respond less well than those who had an uneventful course. The data are interpreted as indicating the desirability of avoiding generalizations concerning all infants of diabetic mothers.

Umbilical Cord Glycosylated Hemoglobin in Infants of Diabetic Mothers: Relationships to Neonatal Hypoglycemia, Macrosomia, and Cord Serum C-Peptide

Diabetes Care ◽  
1982 ◽  
Vol 5 (6) ◽  
pp. 566-570 ◽  
Author(s):  
J. M. Sosenko ◽  
J. L. Kitzmiller ◽  
R. Fluckiger ◽  
S. W. H. Loo ◽  
D. M. Younger ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Glycosylated Hemoglobin ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Cord Serum ◽  
Diabetic Mothers

Relation of enteroinsular hormones at birth to macrosomia and neonatal hypoglycemia in infants of diabetic mothers

1983 ◽  
Vol 103 (4) ◽  
pp. 603-611 ◽  
Author(s):  
Mikael Knip ◽  
Pentti Lautala ◽  
Juhani Leppäluoto ◽  
Hans K. Akerblom ◽  
Kauko Kouvalainen
Keyword(s):  
Neonatal Hypoglycemia ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

scholarly journals Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

2020 ◽  
Author(s):  
Ahlam Saber ◽  
Magdy Mohamed ◽  
Abdelrahim Sadek ◽  
Ramadan Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background: Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.Material and methods: UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected.Results: In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value= 0.43). The hypoglycemia peak occurred within the first 3 hours of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96) compared to normoglycemic babies (HbA1C 6.11 ± 0.38), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005).Conclusion: Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

Continuous glucose monitoring as a screening tool for neonatal hypoglycemia in infants of diabetic mothers

2018 ◽  
Vol 33 (11) ◽  
pp. 1889-1894 ◽  
Author(s):  
Kryštof Tabery ◽  
Miloš Černý ◽  
Krzysztof Urbaniec ◽  
Miroslav Vaniš ◽  
Petr Zoban ◽  
...  
Keyword(s):  
Continuous Glucose Monitoring ◽  
Screening Tool ◽  
Glucose Monitoring ◽  
Neonatal Hypoglycemia ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

scholarly journals Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ahlam M. Saber ◽  
Magdy A. Mohamed ◽  
Abdelrahim A. Sadek ◽  
Ramadan A. Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia. Material and methods UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected. Results In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value = 0.43). The hypoglycemia peak occurred within the first 3 h of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96%) compared to normoglycemic babies (HbA1C 6.11 ± 0.38%), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005). Conclusion Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

STUDIES ON RESPIRATORY RATE IN THE NEWBORN

PEDIATRICS ◽  
1956 ◽  
Vol 17 (2) ◽  
pp. 204-213 ◽  
Author(s):  
Heskel M. Haddad ◽  
David Yi-Yung Hsia ◽  
Sydney S. Gellis
Keyword(s):  
Cesarean Section ◽  
Premature Infants ◽  
Full Term ◽  
Controlled Trials ◽  
Term Infants ◽  
Infants Of Diabetic Mothers ◽  
Hyaline Membranes ◽  
High Incidence ◽  
Simple Measurement ◽  
Diabetic Mothers

Data has been presented to show that the respiratory rates of infants of diabetic mothers are significantly higher than those of normal full-term infants. [SEE TABLE VI IN SOURCE PDF]. Although the respiratory rates of premature infants and normal infants delivered by cesarean section are slightly higher than those of normal full-term infants, they are insufficient to account for the marked increase of respiratory rates in infants of diabetic mothers. The high incidence of pulmonary hyaline membranes in these infants appears to be the most likely explanation for the elevated respiratory rates. Cortisone does not appear to materially affect the respiratory distress nor the respiratory rates in infants of diabetic mothers. Although the results obtained in the present study do not directly clarify either the etiology nor the mechanism for formation of hyaline membranes in infants of diabetic mothers, the simple measurement of respiratory rates does provide an objective means for evaluating therapy in controlled trials.

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