CALCIUM DEFICIENCY RICKETS AND THE RENAL RESPONSE TO CALCIUM INFUSION

The diagnosis in a 1-year-old female with skeletal and chemical rickets, generalized hyperaminoaciduria, and metabolic acidosis was uncertain, and primary renal disease (i.e., Fanconi "syndrome") was considered. She had been on a diet which was deficient in calcium (approximately 21 to 36 mg calcium daily) but adequate for phosphorus and vitamin D. Her skeletal and renal lesions resolved within 3 months on a high calcium diet. Early in her hospital course, an intravenous calcium infusion provided 10 mg/kg calcium, as calcium gluconate over 3 hours; 8 to 10 hours later, a significant reduction in urinary amino acids and phosphorus was observed. The mechanism through which this response was mediated is postulated to be via reduction in circulating parathormone.

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Calcium Deficiency Rickets?: Fanconi Syndrome?

PEDIATRICS ◽

10.1542/peds.47.5.958 ◽

1971 ◽

Vol 47 (5) ◽

pp. 958-959

Author(s):

Gerard Fareau ◽

Malcolm A. Holliday

Keyword(s):

Fanconi Syndrome ◽

Clinical Laboratory ◽

Calcium Deficiency ◽

Cow’S Milk ◽

Milk Allergy ◽

X Ray ◽

Cow's Milk ◽

Severe Diarrhea ◽

Milk Substitute ◽

Deficiency Rickets

With regard to the article1 by Drs. Maltz, Fish, and Holliday in the December, 1970, issue, it seems to me that a child who keeps having severe diarrhea on regular feedings and improves on a milk substitute diet is probably suffering from cow's milk allergy. The fact that the patient tolerated cow's milk at 13 months of age does not rule this out. I would also like to point out that all the clinical, laboratory, and x-ray findings described by the authors are those of Vitamin D deficiency rickets.

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Protein and mineral metabolism in pregnant sows on a normal or high calcium diet compared with a calcium-deficient diet

The Journal of Agricultural Science ◽

10.1017/s0021859600013459 ◽

1929 ◽

Vol 19 (4) ◽

pp. 752-798 ◽

Cited By ~ 21

Author(s):

R. E. Evans

Keyword(s):

Calcium Carbonate ◽

Detrimental Effect ◽

Mineral Metabolism ◽

Live Weight ◽

Calcium Deficiency ◽

Physiological Effects ◽

Deficient Diet ◽

High Calcium ◽

High Calcium Diet ◽

Deficient Group

(1) The physiological effects of calcium-deficiency on pregnant sows are briefly discussed. Results are given which demonstrate that a deficiency of lime in the food has no detrimental effect on the live weight of the young piglings at birth thus showing that up to parturition it is the mother organism that suffers and not the offspring.(2) Storage of nitrogen takes place throughout pregnancy but the results indicate a considerably enhanced conservation within three weeks of parturition. The average daily retention of nitrogen by the high-calcium group of sows was 12·51 gm. and by the calcium-deficient group 9·78 gm. The normal sows therefore stored 1439 gm. N and the calcium-deficient 1125 gm. N during the gestation period. It is shown that storage of protein during pregnancy is greatly in excess of the foetal requirement, so that the mother organism, during gestation, adds on a reserve supply of protein in preparation for parturition and lactation.(3) Ash ingredients were retained at all stages of gestation by both groups of sows. The addition of calcium carbonate to the food, however, resulted in an increased retention of ash. The percentage of the ash intake in the faeces was very similar in both groups, but the percentage of the intake in the urine was distinctly higher in the calcium-deficient sows indicating a more economical utilisation of ash by this group.

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THE INTRAVENOUS CALCIUM INFUSION TEST

Acta Endocrinologica ◽

10.1530/acta.0.056s031 ◽

1967 ◽

Vol 56 (1_Suppl) ◽

pp. S31 ◽

Cited By ~ 1

Author(s):

B.-A. Lamberg ◽

P. Torsti ◽

J. Takkunen

Keyword(s):

Infusion Test ◽

Calcium Infusion ◽

Intravenous Calcium

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Equal Calcitonin Response in Paretic and Non-Paretic Cows After Intravenous Calcium Infusion

Acta Veterinaria Scandinavica ◽

10.1186/bf03546881 ◽

1980 ◽

Vol 21 (2) ◽

pp. 171-184

Author(s):

Kristina Forslund ◽

Kerstin Lundström ◽

Lars-Erik Edqvist

Keyword(s):

Calcium Infusion ◽

Intravenous Calcium

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No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

Animals ◽

10.3390/ani11061799 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1799

Author(s):

Jujhar Atwal ◽

Jonathan Stockman ◽

Matthew Gilham ◽

David Allaway ◽

Helen Renfrew ◽

...

Keyword(s):

Filtration Rate ◽

Fold Increase ◽

Diet Group ◽

Test Diet ◽

Beagle Dogs ◽

Adverse Health Effects ◽

Mineral Balance ◽

High Calcium ◽

High Calcium Diet

The implications of long-term high calcium (Ca) intake are well documented in growing dogs and in adult dogs of large breed size, however, the consequences on other breeds and breed sizes are yet to be determined. Eighteen neutered adult beagles, nine males and nine females aged 1.4–4.4 years, were randomized to control or test diets providing in g∙4184 kJ−1 (1000 kcal−1): 1.44 and 7.19 total Ca balanced with 1.05 and 4.25 total phosphorus, respectively, for 40 weeks. Health parameters, ultrasound scans, radiographs, glomerular filtration rate, and mineral balance were measured at eight-week intervals. All dogs remained healthy with no measured evidence of orthopedic, urinary, or renal disease. The test diet resulted in a 5.2 fold increase in fecal Ca excretion. Apparent Ca digestibility (%) and Ca balance (g/d) did not significantly (p > 0.05) change from baseline in the test diet group, although dogs displayed a positive Ca balance (maximum at week 8, 1.11 g/d with 95% CI (0.41, 1.80)) before a neutral Ca balance was restored at week 32. Despite an initial positive Ca balance, we can conclude that no measurable adverse health effects were observed as a result of the test diet fed in this study in beagles over a period of 40 weeks.

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Parathyroid Hormone- and Deoxycorticosterone Acetate-Induced Hypertension in the Rat

Clinical Science ◽

10.1042/cs0580365 ◽

1980 ◽

Vol 58 (5) ◽

pp. 365-371 ◽

Cited By ~ 28

Author(s):

A. Berthelot ◽

A. Gairard

Keyword(s):

Parathyroid Hormone ◽

Hormone Secretion ◽

Sprague Dawley ◽

Physiological Concentration ◽

Deoxycorticosterone Acetate ◽

Calcium Diet ◽

Arterial Blood ◽

Sprague Dawley Rats ◽

High Calcium ◽

High Calcium Diet

1. Hypertension induced by treatment with deoxycorticosterone acetate and sodium chloride was studied in male Sprague-Dawley rats and related to parathyroid hormone secretion. 2. Lack of parathyroid hormone (due to parathyroidectomy) or decreased parathormone secretion (due to a high-calcium diet) partially inhibited the development of arterial hypertension. 3. In contrast, in thyroparathyroidectomized rats supplemented with thyroxine, the administration of parathyroid hormone rapidly elevated arterial blood pressure. 4. Maintaining a physiological concentration of serum calcium in the absence of parathyroid hormone (by feeding a high-calcium diet to parathyroidectomized rats) was not sufficient to establish mineralocorticoid hypertension. 5. These results show that parathyroid hormone is necessary for the complete development of mineralocorticoid hypertension.

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