A Therapeutic Trial of Fatty Acid Supplementation in Cystic Fibrosis

PEDIATRICS ◽  
1976 ◽  
Vol 57 (4) ◽  
pp. 474-479
Author(s):  
Robert B. Elliott
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Clinical Course ◽  
Therapeutic Trial ◽  
Biochemical Abnormality ◽  
Fatty Acid Supplementation ◽  
Oil Emulsion ◽  
Soya Oil ◽  
One Year ◽  
Better Than

Seven children with cystic fibrosis (CF) have been treated for at least one year with intravenously administered soya oil emulsion. In all, an improvement of at least one biochemical abnormality in character with the disease appeared. The children's clinical course remains benign. This course is remarkably better than that of other children with CF treated without Intralipid in Auckland in the same period, though a placebo effect cannot be discounted. It is postulated that intravenous supplementation with essential fatty acid in CF may in turn partially correct an error of metabolism of prostaglandins present in the disease.

A comprehensive evaluation of omega-3 fatty acid supplementation in cystic fibrosis patients using lipidomics

2019 ◽  
Vol 63 ◽  
pp. 197-205 ◽  
Author(s):  
Óscar Pastor ◽  
Paula Guzmán-Lafuente ◽  
Jorge Serna ◽  
Marta Muñoz-Hernández ◽  
Alejandro López Neyra ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Comprehensive Evaluation ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

Negative Effects of Oral Fatty Acid Supplementation on Sweat Chloride in Cystic Fibrosis

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 50-52
Author(s):  
John D. Lloyd-Still ◽  
Stuart H. Simon ◽  
Hans U. Wessel ◽  
Lewis E. Gibson
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Sweat Rate ◽  
Chloride Concentration ◽  
Control Group ◽  
Safflower Oil ◽  
Negative Effects ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Sweat Chloride

Essential fatty acid supplementation with oral safflower oil (1 gm/kg/day) to 11 cystic fibrosis patients (aged 6 months to 14 years) for one year produced no significant change in sweat chloride concentration (mEq/liter) or sweat rate (gm/min/m2). Addition of vitamin E (10 mg/kg/day) to the safflower oil had no effect on sweat chloride concentration or rate compared to placebo. No clinical improvement could be detected compared to a control group. These results do not support previous reports of the effects of fatty acid supplementation on sweat electrolyte concentrations in cystic fibrosis.

Triglyceride Levels After Intralipid Infusion in Children With Cystic Fibrosis

PEDIATRICS ◽  
1978 ◽  
Vol 61 (6) ◽  
pp. 924-925
Author(s):  
Xavier Allué ◽  
Pablo Sanjurjo
Keyword(s):  
Cystic Fibrosis ◽  
Body Weight ◽  
Fatty Acid ◽  
Soybean Oil ◽  
Essential Fatty Acid ◽  
Biochemical Data ◽  
Oil Emulsion

Infusions of soybean oil emulsion (Intralipid) have been reported to correct essential fatty acid (EFA) deficiency in patients with cystic fibrosis of the pancreas (CF).1 The Intralipid dosage used by Elliot1 was 2 gm/kg of body weight given over a period of four hours. This article reports the immediate effects of Intralipid infusion in patients with CF in an attempt to ascertain through biochemical data whether the use of Intralipid at the reported dose is free of untoward effects. MATERIALS AND METHODS Six patients with CF were placed in a protocol that called for periodic infusions with soybean oil emulsion containing EFAs.

Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis

2007 ◽  
Vol 77 (5-6) ◽  
pp. 309-318 ◽  
Author(s):  
M. Rabie Al-Turkmani ◽  
Steven D. Freedman ◽  
Michael Laposata
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation
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