Negative Effects of Oral Fatty Acid Supplementation on Sweat Chloride in Cystic Fibrosis

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 50-52
Author(s):  
John D. Lloyd-Still ◽  
Stuart H. Simon ◽  
Hans U. Wessel ◽  
Lewis E. Gibson
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Sweat Rate ◽  
Chloride Concentration ◽  
Control Group ◽  
Safflower Oil ◽  
Negative Effects ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Sweat Chloride

Essential fatty acid supplementation with oral safflower oil (1 gm/kg/day) to 11 cystic fibrosis patients (aged 6 months to 14 years) for one year produced no significant change in sweat chloride concentration (mEq/liter) or sweat rate (gm/min/m2). Addition of vitamin E (10 mg/kg/day) to the safflower oil had no effect on sweat chloride concentration or rate compared to placebo. No clinical improvement could be detected compared to a control group. These results do not support previous reports of the effects of fatty acid supplementation on sweat electrolyte concentrations in cystic fibrosis.

A comprehensive evaluation of omega-3 fatty acid supplementation in cystic fibrosis patients using lipidomics

2019 ◽  
Vol 63 ◽  
pp. 197-205 ◽  
Author(s):  
Óscar Pastor ◽  
Paula Guzmán-Lafuente ◽  
Jorge Serna ◽  
Marta Muñoz-Hernández ◽  
Alejandro López Neyra ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Comprehensive Evaluation ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial

2017 ◽  
Vol 118 (11) ◽  
pp. 971-980 ◽  
Author(s):  
Valene H. L. See ◽  
Emilie Mas ◽  
Susan L. Prescott ◽  
Lawrence J. Beilin ◽  
Sally Burrows ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cord Blood ◽  
Intervention Strategy ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Human Cord Blood ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation

AbstractResolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3·7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P<0·001) derived from EPA relative to the control group. DHA-derived 17-HDHA at birth was significantly increased in the n-3 fatty acid group relative to the controls (P=0·001), but other SPM were not different between the groups. n-3 Fatty acid supplementation during pregnancy was associated with an increase in SPM precursors in the offspring at birth but the effects were not sustained at 12 years. The presence of these SPM, particularly at birth, may have functions relevant in the newborn that remain to be established, which may be useful for future investigations.

Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis

2007 ◽  
Vol 77 (5-6) ◽  
pp. 309-318 ◽  
Author(s):  
M. Rabie Al-Turkmani ◽  
Steven D. Freedman ◽  
Michael Laposata
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation

Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation

2018 ◽  
Vol 28 (7) ◽  
pp. 949-954 ◽  
Author(s):  
Taliha Oner ◽  
Rahmi Ozdemir ◽  
Onder Doksöz ◽  
Dildar B. Genc ◽  
Baris Guven ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Premature Ventricular Contraction ◽  
Left Ventricular ◽  
Control Group ◽  
Omega 3 ◽  
Ventricular Contraction ◽  
Premature Ventricular Contractions ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation

AbstractBackgroundPremature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial.MethodsA total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group.ResultsCompared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation.ConclusionIn conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.

Fatty Acid Supplementation Improves Respiratory, Inflammatory and Nutritional Parameters in Adults with Cystic Fibrosis

2010 ◽  
Vol 46 (2) ◽  
pp. 70-77 ◽  
Author(s):  
Gabriel Olveira ◽  
Casilda Olveira ◽  
Eva Acosta ◽  
Francisco Espíldora ◽  
Lourdes Garrido-Sánchez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Nutritional Parameters
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