Evaluation of the Minolta Bilirubin Meter as a Screening Device in White and Black Infants

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 107-109 ◽  
Author(s):  
Robert E. Hannemann ◽  
Richard L. Schreiner ◽  
David P. DeWitt ◽  
Steven A. Norris ◽  
Melvin R. Glick
Keyword(s):  
Premature Infants ◽  
Serum Bilirubin ◽  
Full Term ◽  
Blood Sampling ◽  
Published Data ◽  
Bilirubin Concentration ◽  
Transcutaneous Bilirubin ◽  
Screening Device ◽  
Serum Bilirubin Concentration

The only currently available method for the determination of the serum bilirubin concentration is blood sampling followed by analysis in the laboratory. Yamanouchi et al1 have presented data concerning a two-wavelength (460, 555 nm) transcutaneous bilirubin meter (Minolta Camera Company, Ltd). They found a significant correlation with serum bilirubin concentrations of 0 to 20 mg/100 ml in full-term Oriental infants. However, there are no published data concerning the use of the instrument in white or black full-term or premature infants. The purpose of this study was to evaluate the Minolta transcutaneous bilirubin meter in these populations. MATERIALS AND METHODS During a two-month period, measurements were taken with the Minolta transcutaneous bilirubin meter on any infant for whom a serum bilirubin determination had been ordered.

Transcutaneous Bilirubin Measurements: Variation in Meter Response

PEDIATRICS ◽  
1983 ◽  
Vol 71 (3) ◽  
pp. 457-459
Author(s):  
M. JEFFREY MAISELS ◽  
CHERYL LEE
Keyword(s):  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Full Term ◽  
Term Infants ◽  
Transcutaneous Bilirubin ◽  
Potential Variation ◽  
Screening Device ◽  
The Relationship

The transcutaneous bilirubin meter has been shown to be a useful screening device for the identification of significant neonatal jaundice in full-term infants.1-3 Investigators have, nevertheless, emphasized the necessity for each institution to establish the relationship between the transcutaneous bilirubin index, as measured with a particular instrument, and the serum bilirubin determination obtained from the institution's laboratory. 3 This is important, because of the known variation between laboratories in the measurement of serum bilirubin concentration4 and because no information has been published regarding the potential variation in the response of different transcutaneous bilirubin meters.

Transcutaneous Bilirubin Measurements in Full-Term Infants

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 464-467 ◽  
Author(s):  
M. Jeffrey Maisels ◽  
Sarah Conrad
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
False Positive ◽  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
False Negative ◽  
Full Term ◽  
Bilirubin Concentration ◽  
Term Infants ◽  
Transcutaneous Bilirubin

A total of 292 transcutaneous bilirubin (TcB) measurements were performed in 157 white full-term infants: 157 were obtained from the forehead and 135 from the midsternum. TcB measurements correlated well with serum bilirubin determinations (r = .93, P < .0001). The sensitivity of the test was 100% and the specificity 97%. It was possible to establish guidelines for the TcB measurement which identified all infants whose serum bilirubin concentrations exceeded 12.9 mg/100 ml (221 µmoles/liter) with no false-negative and only five false-positive determinations (3%). The positive predictive value for the TcB measurements was 58%. This implies that, in our population, an infant with a TcB index ≥24 has a 58% chance of having a serum bilirubin concentration >12.9 mg/100 ml. The negative predictive value was 100%. Thus, a negative test will correctly predict the absence of hyperbilirubinemia in all cases. As these measurements were obtained prospectively in a well-baby population with a prevalence of hyperbilirubinemia (>12.9 mg/100 ml) of 4.5%, the positive predictive value should be applicable to other similar populations and will, in fact, increase in populations with a higher prevalence of hyperbilirubinemia. TcB measurements can be recommended for the identification of significant neonatal jaundice in full-term infants. It is important to recognize, however, that because of potential variations in TcB meters as well as serum bilirubin measurements in different laboratories, each institution should establish its own criteria for the use of this instrument.

scholarly journals Determination of Serum Bilirubin Concentration during Phototherapy of Newborns and In Vitro: Results Compared by the Direct Spectrometric Method and the Diazo Method

1977 ◽  
Vol 23 (4) ◽  
pp. 695-699 ◽  
Author(s):  
Finn Ebbesen
Keyword(s):  
Premature Infants ◽  
Serum Bilirubin ◽  
Blood Type ◽  
Spectrometric Method ◽  
Hemolytic Disease ◽  
Bilirubin Concentration ◽  
Term Infants ◽  
Direct Illumination

Abstract During direct illumination of a serum bilirubin solution the bilirubin concentration decreased markedly, both as de-termined by the direct spectrometric method and (even more so) by the diazo method. In contrast, I found the same values for serum bilirubin concentrations as determined by these two methods for serum from untreated, "single light," and "double light" treated full-term infants with neonatal hyperbilirubinemia without blood type immuni¬zation. The same was true for untreated and "single light" treated premature infants with this disease. Furthermore, no difference was found in the above-mentioned rela¬tionship between "single light" treated infants with rhesus hemolytic disease, "double light" treated infants with the same disease, and untreated infants with neonatal hyp¬erbilirubinemia without immunization, all born at term. This is important, because the direct spectrometric method is simpler and requires less serum than does the diazo method

scholarly journals The Observation of the Curative Effects of Nursing Intervention on the Premature Infant with Jaundice

2015 ◽  
Vol 4 (3) ◽  
pp. 19
Author(s):  
Hui Yang
Keyword(s):  
Premature Infants ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Serum Bilirubin ◽  
Abdominal Distension ◽  
Nursing Intervention ◽  
Control Group ◽  
Observation Group ◽  
Bilirubin Concentration ◽  
Serum Bilirubin Concentration

<strong>Objective:</strong> To analyze the clinical effect of comprehensive nursing intervention on preterm infant with jaundice. <strong>Methods: </strong>During the treatment in our hospital as the research purpose from January 2004 to January 2014, 94 cases of premature infants were randomly divided into two groups which is control group and observation group. For control group patients, they were given routine nursing while the observation group patients were given comprehensive nursing intervention. These two groups of patients were analyzed with serum bilirubin concentration respectively, the comparison between patient weight and the time of fetal turn yellow and the occurrence of the disease. <strong>Results:</strong> Compared to control group, the serum bilirubin concentration in the observation group was significantly decreased, weight and meconium turned yellow time increased significantly, the incidence of complications such as apnea, abdominal distension and feeding intolerance was significantly lower and the differences were statistically significant (<em>p</em> &lt; 0.05). <strong>Conclusion:</strong> Comprehensive nursing intervention can effectively improve the growth and development of premature infants and recovery, reduce the incidence of adverse reactions, has a significant clinical effect and it is worth promoting.

scholarly journals Transcutaneous billirubinometry to estimate total serum bilirubin in neonatal jaundice

2017 ◽  
Vol 57 (1) ◽  
pp. 8 ◽  
Author(s):  
Andra Kurnianto ◽  
Herman Bermawi ◽  
Afifa Darmawanti ◽  
Erial Bahar
Keyword(s):  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Subcutaneous Tissue ◽  
Correlation Coefficients ◽  
Total Serum Bilirubin ◽  
Blood Sampling ◽  
Total Serum ◽  
Transcutaneous Bilirubin ◽  
Non Invasive ◽  
Transcutaneous Bilirubinometry

Background The gold standard for diagnosis of neonatal jaundice is total serum bilirubin (TSB) measurement. This method, however, is invasive, painful, and costly in terms of workload, time, and money. Moreover, repeated blood sampling may lead to significant blood loss, which is of particular concern in preterm infants. To overcome these drawbacks, non-invasive methods of bilirubin measurement have been proposed. Transcutaneous bilirubinometry (TcB) determines the yellowness of the subcutaneous tissue of a newborn infant by measuring the difference between optical densities for light in the blue and green wavelength regions.Objective To evaluate the accuracy of transcutaneous bilirubinometry for estimating TSB levels in neonatal jaundice.Methods Subjects were infants aged < 28 days with jaundice who had never been treated with phototherapy or exchange transfusion. The study was done from February to July 2016 in Mohammad Hoesin Hospital. Subjects underwent transcutaneous bilirubin (TcB) and TSB assays, with a maximum interval of 15 minutes between tests.Results One hundred fifty patients were included in this study. The TcB values > 5 mg/dL were correlated to TSB > 5 mg/dL, with 100% sensitivity and 83.3% specificity. This cut-off point was obtained from a receiver-operator characteristic (ROC) curve with AUC 99.3% (95%CI 97.9 to 100%; P< 0.001).The correlation coefficients (r) for TSB and TcB measurements on the forehead were 0.897 (P<0.001).Conclusion Transcutaneous bilirubinometry can be used to accurately estimate TSB levels in neonatal jaundice, and may be useful in clinical practice as a non-invasive method to reduce blood sampling.

Tin-protoporphyrin in the Management of Children With Crigler-Najjar Disease

PEDIATRICS ◽  
1990 ◽  
Vol 86 (1) ◽  
pp. 152-152
Author(s):  
FIRMINO F. RUBALTELLI ◽  
GIULIO JORI
Keyword(s):  
Serum Bilirubin ◽  
Bilirubin Concentration ◽  
Tin Protoporphyrin ◽  
Low Levels ◽  
Serum Bilirubin Concentration

In Reply.— We have considered carefully the points raised by Dr McDonagh and answer as follows: Regarding points 1 and 2, Fig 2 (second plot from the bottom) of our paper clearly shows that administration of SnPp to the patient with Crigler-Najjar type 1 disease reduces the serum bilirubin concentration to values ranging between 12 and 15 mg/dL for at least a week. In the absence of SnPp treatment, the infant never reached such low levels even during sunny seasons, unless phototherapy was performed.

Low serum bilirubin concentration is associated with coronary artery calcification (CAC)

2009 ◽  
Vol 206 (1) ◽  
pp. 287-291 ◽  
Author(s):  
Muhei Tanaka ◽  
Michiaki Fukui ◽  
Ki-ichiro Tomiyasu ◽  
Satoshi Akabame ◽  
Koji Nakano ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Serum Bilirubin ◽  
Bilirubin Concentration ◽  
Low Serum ◽  
Serum Bilirubin Concentration

YELLOW SKIN A BETTER PREDICTOR?

PEDIATRICS ◽  
1989 ◽  
Vol 84 (6) ◽  
pp. A45-A45
Author(s):  
Student
Keyword(s):  
Brain Damage ◽  
Clinical Utility ◽  
Serum Bilirubin ◽  
High Serum ◽  
Bilirubin Concentration ◽  
Yellow Colour ◽  
The Brain ◽  
Reserve Albumin ◽  
High Serum Bilirubin ◽  
Serum Bilirubin Concentration

If kernicterus develops in an infant due to high serum bilirubin, low reserve albumin, and acidosis, bilirubin acid will also be deposited in the skin. In consequence, it seems possible that the yellow colour of the skin is correlated with that of the brain, to the extent that bilirubin deposition in the skin has occurred by precipitation of bilirubin acid. If so, the intensity of the yellow colour of the skin may be a somewhat better predictor of brain damage than the serum bilirubin concentration and measurement of the colour of the skin may theoretically be of clinical utility.

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