TrophAmine

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 388-389
Author(s):  
STANLEY H. ZLOTKIN
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Nitrogen Retention ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Acid Solutions ◽  
Low Birth Weight Infants ◽  
Amino Acid Solutions

To the Editor.— Heird et al1 recently described the use of a new parenteral amino acid mixture for low birth weight infants which included a peptide of tyrosine (N-acetyl-l-tyrosine). They concluded that infants tolerated the new mixture well and stated that it was "more efficacious with respect to nitrogen retention and weight gain than other available mixtures." It is my contention that their results do not substantiate their claims. First, the efficiency of nitrogen retention with TrophAmine (70% retention) is not superior to older amino acid solutions.

TrophAmine

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 389-390
Author(s):  
WILLIAM C. HEIRD
Keyword(s):  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Controlled Trial ◽  
Nitrogen Retention ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Concerted Effort ◽  
Low Birth Weight Infants ◽  
Amino Acid Concentrations

In Reply.— The purpose of the study reported in the paper1 to which Zlotkin refers was to evaluate the efficacy of a new parenteral amino acid mixture (ie, TrophAmine) with respect to maintaining "normal" plasma amino acid concentrations and promoting nitrogen retention in low birth weight infants. Because the study was not a controlled trial in which this amino acid mixture was compared with another mixture, a concerted effort was made to avoid drawing conclusions or stating claims regarding the efficacy of this amino acid mixture relative to other mixtures.

Amino Acids in Premature Infants

PEDIATRICS ◽  
1988 ◽  
Vol 82 (4) ◽  
pp. 680-680
Author(s):  
NIELS C. R. RÄIHÄ
Keyword(s):  
Amino Acids ◽  
Birth Weight ◽  
Amino Acid ◽  
Parenteral Nutrition ◽  
Premature Infants ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Metabolic Capacity ◽  
Low Birth Weight Infants ◽  
Term Infants

To the Editor.— In a recent paper in Pediatrics, Heird et al1 reported their evaluation of the use of a new amino acid mixture for parenteral nutrition in low birth weight infants. On the basis of their results the authors made the following statement: "These observations refute the concept that the metabolic capacity of LBW infants for amino acids is limited in comparison to that of term infants, older infants, and chi1dren."1(p49) Such a conclusion is not justified on the basis of the presented data.

scholarly journals Biochemical homeostasis and body growth are reliable end points in clinical nutrition trials

2005 ◽  
Vol 64 (3) ◽  
pp. 297-303 ◽  
Author(s):  
William C. Heird
Keyword(s):  
Fatty Acids ◽  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Linolenic Acid ◽  
Essential Fatty Acids ◽  
Plasma Concentrations ◽  
Body Growth ◽  
Acid Mixture ◽  
Low Birth Weight Infants

Studies of biochemical homeostasis and/or body growth have been included as outcome variables in most nutrition trials in paediatric patients. Moreover, these outcome variables have provided important insights into the nutrient requirements of infants and children, and continue to do so. Examples of the value of such studies in improving parenteral nutrition, in defining essential fatty acid metabolism and requirements of infants and in defining the protein and energy needs of low-birth-weight infants are discussed. Data from such studies have helped to define the mechanism of metabolic acidosis and hyperammonaemia associated with the use of early crystalline amino acid mixture and, hence, how to prevent these disorders. Such studies have allowed the development of parenteral amino acid mixtures that circumvent grossly abnormal plasma concentrations of most amino acids and appear to be utilized more efficiently. These studies have also helped define micronutrient requirements, including requirements for several such nutrients that had not been previously recognized as essential (e.g. Cr, Se, Mo, α-linolenic acid). Studies of body growth have been particularly valuable in defining the nutritional requirements of low-birth-weight infants. Finally, studies of metabolic homeostasis coupled with more sophisticated metabolic studies have provided considerable insight into the metabolism of the essential fatty acids, linoleic acid (18:2n-6) and α-linolenic acid (18:3n-3). Although such studies have not defined the amount of the longer-chain PUFA synthesized from each of these essential fatty acids, i.e. arachidonic acid (20:4n-6) and DHA (22:6n-3), they have shown that the rates of conversion are extremely variable from infant to infant, suggesting a possible explanation of why some studies show developmental advantages from intake of these fatty acids while others do not.

Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth

2017 ◽  
Vol 18 ◽  
pp. 16-22 ◽  
Author(s):  
Kenneth Strømmen ◽  
Alexander Haag ◽  
Sissel J. Moltu ◽  
Marit B. Veierød ◽  
Elin W. Blakstad ◽  
...  
Keyword(s):  
Birth Weight ◽  
Amino Acid ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Nutrient Supply ◽  
Low Birth Weight Infants ◽  
Amino Acid Concentrations

Energy expenditure, energy balance, and composition of weight gain in low birth weight infants fed diets of different protein and energy content

1987 ◽  
Vol 110 (5) ◽  
pp. 753-759 ◽  
Author(s):  
Karl F. Schulze ◽  
Mark Stefanski ◽  
Julia Masterson ◽  
Regina Spinnazola ◽  
Rajasekhar Ramakrishnan ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Low Birth Weight ◽  
Energy Content ◽  
Low Birth Weight Infants
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